Computer Modeling of Bevacizumab Drug Distribution after Intravitreal Injection in Rabbit and Human Eyes DOI Open Access

Jabia M. Chowdhury,

Eduardo A. Chacin Ruiz,

Matthew Ohr

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: May 8, 2023

Age-related macular degeneration (AMD) is a progressive eye disease that causes loss of central vision and has no cure. Wet AMD the late neovascular form treated with vascular endothelial growth factor (VEGF) inhibitors. VEGF critical driver wet AMD. One common off-label anti-VEGF drug used in treatment bevacizumab. Experimental efforts have been made to investigate pharmacokinetic (PK) behavior bevacizumab vitreous aqueous humor. Still, quantitative effect elimination routes concentration macula are not well understood. In this work, we developed two spatial models representing rabbit human better understand PK This study explores different cases effects injection location on profiles. The validated by comparing them experimental data. Our results suggest anterior dominant for clearance from vitreous, whereas both posterior similar importance vitreous. Furthermore, indicate injections closer segment help maintain relevant concentrations longer, improving duration action at fovea, which located center macula. predict enhancing knowledge understanding treatment.

Language: Английский

Evaluation of 3D-Printed Solid Microneedles Coated with Electrosprayed Polymeric Nanoparticles for Simultaneous Delivery of Rivastigmine and N-Acetyl Cysteine DOI
Paraskevi Kyriaki Monou, Eleftherios G. Andriotis, Dimitrios Tzetzis

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(5), P. 2710 - 2724

Published: April 9, 2024

In the current study, coated microneedle arrays were fabricated by means of digital light processing (DLP) printing. Three different shapes designed, printed, and with PLGA particles containing two actives. Rivastigmine (RIV) N-acetyl-cysteine (NAC) coformulated via electrohydrodynamic atomization (EHDA), they incorporated into particles. The actives are administered as a combined therapy for Alzheimer's disease. printed evaluated regarding their ability to penetrate skin mechanical properties. Optical microscopy scanning electron (SEM) employed further characterize structure. Confocal laser studies conducted construct 3D imaging coating simulate diffusion through artificial samples. Permeation performed investigate transport drugs across human

Language: Английский

Citations

3
Preparation, characterisation, pharmacokinetics and distribution of esculin microspheres administered via intravitreal injection into rabbit brain DOI
Danqing Wu, Rui Luo,

Yangnan Chen

et al.

Xenobiotica, Journal Year: 2024, Volume and Issue: 54(5), P. 233 - 247

Published: April 19, 2024

This study explored the distribution of esculin microspheres in rabbit brain tissue following intravitreal injection and investigated possibility direct entry drug into through eye, to develop a formulation with enhanced therapeutic efficacy against Parkinson's disease.Chitosan were prepared

Language: Английский

Citations

2
In silico evaluation of corneal patch eluting anti-VEGF agents concept DOI Creative Commons
Marcin Heljak, Sumeyye Cesur, Elif Ilhan

et al.

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2024, Volume and Issue: 204, P. 114494 - 114494

Published: Sept. 8, 2024

Language: Английский

Citations

0
Computer Modeling of Bevacizumab Drug Distribution After Intravitreal Injection in Rabbit and Human Eyes DOI Creative Commons

Jabia M. Chowdhury,

Eduardo A. Chacin Ruiz,

Matthew Ohr

et al.

Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

0
Computer Modeling of Bevacizumab Drug Distribution after Intravitreal Injection in Rabbit and Human Eyes DOI Open Access

Jabia M. Chowdhury,

Eduardo A. Chacin Ruiz,

Matthew Ohr

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: May 8, 2023

Age-related macular degeneration (AMD) is a progressive eye disease that causes loss of central vision and has no cure. Wet AMD the late neovascular form treated with vascular endothelial growth factor (VEGF) inhibitors. VEGF critical driver wet AMD. One common off-label anti-VEGF drug used in treatment bevacizumab. Experimental efforts have been made to investigate pharmacokinetic (PK) behavior bevacizumab vitreous aqueous humor. Still, quantitative effect elimination routes concentration macula are not well understood. In this work, we developed two spatial models representing rabbit human better understand PK This study explores different cases effects injection location on profiles. The validated by comparing them experimental data. Our results suggest anterior dominant for clearance from vitreous, whereas both posterior similar importance vitreous. Furthermore, indicate injections closer segment help maintain relevant concentrations longer, improving duration action at fovea, which located center macula. predict enhancing knowledge understanding treatment.

Language: Английский

Citations

0