Additive manufacturing, Journal Year: 2024, Volume and Issue: unknown, P. 104472 - 104472
Published: Oct. 1, 2024
Language: Английский
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 658, P. 124195 - 124195
Published: May 3, 2024
Microneedles (MN) have emerged as an innovative technology for drug delivery, offering a minimally invasive approach to administer therapeutic agents. Recent applications included ocular requiring the manufacture of sub-millimeter needle arrays in reproducible and reliable manner. The development 3D printing technologies has facilitated fabrication MN via mold production, although there is paucity information available regarding how parameters may influence crucial issues such sharpness penetration efficacy. In this study, we developed optimized 3D-printed micro-mold using stereolithography (SLA) prepare dissolving patch. effects range including aspect ratio, layer thickness, length, shape orientation been examined with regard both architecture accuracy micro-mold, while angle on fidelity was also basic shapes (conical, pyramidal triangular pyramidal). Mechanical strength vitro polymeric (PVP/PVA) patch produced from reverse molds fabricated height, ratios were assessed, followed by ex vivo studies into excised scleral corneal tissues. optimization process identified required produce sharpest tips highest dimensional fidelity, indicated that these systems would penetrate tissue minimal applied pressure, thereby allowing ease patient self-administration.
Language: Английский
Citations
16
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 97, P. 105785 - 105785
Published: May 15, 2024
Language: Английский
Citations
10
ACS Nano, Journal Year: 2024, Volume and Issue: 18(35), P. 23876 - 23893
Published: Aug. 23, 2024
Fully integrated theranostic devices are highly esteemed in clinical applications, offering immense potential real-time disease monitoring and personalized care. Microneedles (MNs), as innovative wearable devices, boast important advantages biosensing therapy, thus holding significant promise the advancement of diagnostic therapeutic platforms. Encouragingly, advancements electrochemical sensing technology, micronano fabrication, biocompatible materials propelling momentum for MNs-based closed-loop systems, enhancing detection capabilities, biocompatibility, cost-effectiveness. Moreover, notable progress integrating MN chips with other biochips signifies a frontier growth. Successful trials target molecule drug delivery domains herald excellent translational prospects aforementioned platform. Finally, we delineate both challenges opportunities development including continuous monitoring, intelligent control algorithms, safety, regulatory considerations.
Language: Английский
Citations
7
ACS Sensors, Journal Year: 2024, Volume and Issue: 9(5), P. 2294 - 2309
Published: April 24, 2024
Bioanalyte collection by blood draw is a painful process, prone to needle phobia and injuries. Microneedles can be engineered penetrate the epidermal skin barrier collect analytes from interstitial fluid, arising as safe, painless, effective alternative hypodermic needles. Although there are plenty of reviews on various types microneedles their use drug delivery systems, lack systematization application polymeric for diagnosis. In this review, we focus current state art field, while providing information safety, preclinical clinical trials, market distribution, outline what believe will future health monitoring.
Language: Английский
Citations
6
European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 114687 - 114687
Published: March 1, 2025
Dissolving microneedles (MNs) are promising transdermal drug delivery systems that can effectively increase the absorption of drugs. They bypass first layer skin, stratum corneum (SC) and deliver drugs directly into dermis, by dissolving inside interstitial fluid releasing active. The traditional ways MN fabrication involve primarily micromolding, which basically uses silicone molds. Drugs polymer mixture solutions poured these molds after drying arrays carefully removed. In present study, a novel molding process was employed to fabricate MNs containing rivastigmine (RIV). RIV is available as an oral tablet patch. patch (Exelon®), used for managing Alzheimer's symptoms in mild moderate dementia, releases only about 50 % its content, raising concerns dose wastage, environmental impact, patient costs. Thus, selected model combining processes, Digital Light Processing Free-D Molding, Vacuum Compression Molding (VCM) Technique provided MeltPrep®. developed were evaluated regarding their physiochemical characteristics ability penetrate skin without breaking or creating fragments, they withstand forces up 600 N. visualized using optical microscopy, SEM, CLSM examine geometry, surface length (0.708 mm). Permeability studies verified significantly transportation across 9-fold. Histological analysis conducted ensure produced safe applications. Overall, study suggests molding, combination 3D printing VCM produce effective
Language: Английский
Citations
0
International Journal of Applied Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 119 - 126
Published: May 7, 2025
Microneedles (MNDs) have emerged as a transformative technology in transdermal drug delivery, offering minimally invasive alternative to traditional hypodermic needles. These microscale devices allow the direct delivery of medication into dermal layers by creating tiny punctures skin. This article looks in-depth at various types MNDs, including hollow, hydrogel-forming, coated, dissolvable, and solid along with associated manufacturing techniques. are used many medical disciplines reduce side effects, increase patient compliance, enhance efficacy. Examples these specialties include pain treatment, hormone administration, vaccine cosmetic surgeries. Despite their promising advantages, problems education, regulatory obstacles, scalability need be fixed. describes current status MNDs technology, discusses potential changes suggests future directions for study development.
Language: Английский
Citations
0
Additive manufacturing, Journal Year: 2024, Volume and Issue: unknown, P. 104472 - 104472
Published: Oct. 1, 2024
Language: Английский
Citations
1