Engineering the Fungal Peroxygenase for Efficient and Regioselective Hydroxylation of Vitamin Ds and Sterols
Yawen Huang,
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Jie Zhang,
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Fuqiang Chen
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et al.
ACS Catalysis,
Journal Year:
2025,
Volume and Issue:
15(3), P. 1952 - 1960
Published: Jan. 18, 2025
Hydroxylation
of
C25
C–H
bonds
(referring
to
sterols)
is
great
importance
in
vivo
for
metabolizing
sterols
and
vitamin
Ds.
The
biocatalytic
hydroxylation
restricted
by
the
selectivity
activity
enzymes
due
inertness
these
bulky
compounds.
Herein,
we
employed
fungal
unspecific
peroxygenase
from
Agrocybe
aegerita
(AaeUPO)
as
catalyst
develop
efficient
selective
AaeUPO
variants
through
protein
engineering.
After
three
rounds
evolution
using
semirational
design,
2
variants,
G195A/G241V/G318V
(Stev)
Q72K/G195A/G241V
(Veco),
were
determined
be
ideal
catalysts,
showing
a
25-
27-fold
increase
enzyme
an
improvement
25%
over
93%
gram-scale
conversion
D3
25-hydroxyvitamin
D3.
These
two
exhibited
overall
enhanced
catalytic
performance
hydroxylating
other
24
sterol
D
analogues.
This
work
provides
enzymatic
toolbox
synthesize
highly
important
vitamins
into
compounds
interest
under
mild
conditions
with
remarkable
regioselectivity
activity.
Language: Английский
Unlocking the potential of liquid crystals as phase change materials for thermal energy storage
Rahul Karyappa,
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Jiayao Cheng,
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Chanda Ho
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et al.
Energy Materials,
Journal Year:
2025,
Volume and Issue:
5(4)
Published: Jan. 23, 2025
This
review
paper
examines
the
innovative
use
of
liquid
crystals
(LCs)
as
phase
change
materials
in
thermal
energy
storage
systems.
With
rising
demand
for
efficient
storage,
LCs
offer
unique
opportunities
owing
to
their
tunable
transitions,
high
latent
heat,
and
favorable
conductivity.
covers
various
types
LCs,
such
nematic,
smectic,
cholesteric
phases,
roles
enhancing
storage.
It
discusses
mechanisms
LC
transitions
impact
on
efficiency.
Strategies
improve
conductivities
polymers
have
also
been
explored.
One
method
involves
embedding
units
within
molecular
structure
promote
orderly
arrangement,
facilitate
heat
flow,
reduce
phonon
scattering.
Aligning
polymer
chains
through
external
fields
or
mechanical
processes
significantly
improves
intrinsic
The
inclusion
thermally
conductive
fillers
optimization
filler-matrix
interactions
further
boost
performance.
Challenges
related
scalability,
cost-effectiveness,
long-term
stability
LC-based
are
addressed,
along
with
future
research
directions.
synthesizes
current
knowledge
identifies
gaps
literature,
providing
a
valuable
resource
researchers
engineers
develop
advanced
technologies,
contributing
sustainable
solutions.
Language: Английский
Spin-state effect on the efficiency of a post-synthetic modification reaction on a spin crossover complex
Communications Chemistry,
Journal Year:
2025,
Volume and Issue:
8(1)
Published: Feb. 12, 2025
Language: Английский
Anisotropic stimuli-responsive polymeric materials: chemistry and applications
Frontiers in Materials,
Journal Year:
2025,
Volume and Issue:
12
Published: March 13, 2025
Anisotropic
stimuli-responsive
polymeric
materials
(ASRPM)
exhibit
distinct
physical
and
chemical
properties
along
various
orientations
can
respond
to
external
stimuli,
demonstrating
exceptional
adaptability
functional
integration
capabilities.
As
research
advances,
new
discoveries
applications
continue
emerge,
further
enhancing
the
appeal
of
these
materials.
Despite
an
increase
in
related
publications,
there
remains
a
relative
scarcity
systematic
summaries.
In
this
mini-review,
we
summarize
advancements
field
over
past
decade,
focusing
on
structural
properties,
fabrication
methods,
advantages,
potential
ASRPM.
We
present
synthesized
overview
through
illustrative
charts,
aiming
provide
readers
with
representative
snapshot
dynamic
landscape.
Language: Английский
Investigation on induced smectic phases in double hydrogen bond liquid crystal complexes derived from aromatic carboxylic acids: Experimental and quantum chemical approaches
Journal of Molecular Liquids,
Journal Year:
2024,
Volume and Issue:
unknown, P. 126306 - 126306
Published: Oct. 1, 2024
Language: Английский
Mesogenic Architectures for Advanced Drug Delivery: Interrogating Lyotropic and Thermotropic Liquid Crystals
Induja Govindan,
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Arghya Paul,
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Annamalai Rama
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et al.
AAPS PharmSciTech,
Journal Year:
2024,
Volume and Issue:
26(1)
Published: Dec. 5, 2024
Abstract
The
possibility
of
precisely
regulating
and
targeting
drug
release
with
mesophase
or
Liquid
crystal
delivery
systems
has
drawn
much
attention
recently.
This
review
offers
a
thorough
investigation
liquid
an
emphasis
on
their
mesogenic
architecture.
It
describes
the
various
forms
such
as
thermotropic
lyotropic
crystals
applicability
in
advanced
delivery.
are
used
excellent
carriers
due
to
distinctive
characteristics,
stimuli-responsive
sustained
patterns.
Comprehending
materials
that
form
provides
insight
into
distinct
physiochemical
characteristics
use
highlights
important
role
play
delivery,
underscoring
considerable
potential.
transition
from
conventional
technological
applications
been
studied.
Nonetheless,
few
challenges
still
need
be
addressed,
including
formulation
strategy
refinement,
rates,
maximising
loading
hydrophilic
drugs,
storage
stability.
In
pharmaceutical
field,
addressing
these
issues
will
open
door
revolutionary
paradigm
revolutionise
therapeutic
outcomes
improve
patient
care.
Graphical
Language: Английский