Development and Characterization of Luteolin Loaded Niosomesfor Effective Deliveryin Wound Healing

Biosciences Biotechnology Research Asia, Journal Year: 2025, Volume and Issue: 22(1), P. 375 - 394

Published: March 25, 2025

ABSTRACT: This study focuses on the development of luteolin-loaded niosomes aimed at enhancing therapeutic efficacy and bioavailability luteolin for wound healing applications. Luteolin, despite its potential, faces significant limitations such as low absorption, poor water solubility, reduced bioavailability. To overcome these challenges, a sustained-release formulation was developed topical application. The optimized using Design Expert software (Version 11) inBox-Behnken (BBD) through response surface methodology. Niosomes were prepared via thinfilm hydration method, with three factors two levels used in optimization process. niosomal preparationswere evaluated by polydispersity index (PDI), zeta vesicle size, entrapment efficiency (EE), Fouriertransform infrared spectroscopy (FTIR), in-vitro drug release profile. showed size 267.2 nm, PDI 0.34, potential -20.25 mV, an EE 78.31%. In-vitro studies established sustained 67.08% over 12 hours. These results demonstrate that formulations have release, improving shows promise addressing issues effectiveness management.

Language: Английский

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Chitosan as a multifunctional polymer in drug delivery systems for diabetic wound management

Polymer Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Language: Английский

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Advances in nucleic acid delivery strategies for diabetic wound therapy

Journal of Clinical & Translational Endocrinology, Journal Year: 2024, Volume and Issue: 37, P. 100366 - 100366

Published: Aug. 30, 2024

In recent years, the prevalence of diabetic wounds has significantly increased, posing a substantial medical challenge due to their propensity for infection and delayed healing. These not only increase mortality rates but also lead amputations severe mobility issues. To address this, advancements in bioactive molecules such as genes, growth factors, proteins, peptides, stem cells, exosomes into targeted gene therapies have emerged preferred strategy among researchers. Additionally, integration photothermal therapy (PTT), nucleic acid, therapy, along with 3D printing technology layer-by-layer (LBL) self-assembly approach, shows promise wound treatment. Effective delivery small interfering RNA (siRNA) relies on vectors. This review provides an in-depth exploration pathophysiological characteristics observed wounds, encompassing diminished angiogenesis, heightened levels reactive oxygen species, impaired immune function. It further examines acid delivery, advanced drug systems, techniques, negative pressure (NPWT), printing, hyperbaric ongoing clinical trials. Through research insights, this presents innovative strategies aimed at augmenting multifaceted management thus paving way enhanced therapeutic outcomes future.

Language: Английский

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Exploration of the Topical Nanoemulgel Bearing with Ferulic Acid and Essential Oil for Diabetic Wound Healing

Pathophysiology, Journal Year: 2024, Volume and Issue: 31(4), P. 680 - 698

Published: Nov. 25, 2024

To investigate the anti-inflammatory, antioxidant, and diabetic wound healing properties of novel topical formulation [Ferulic acid-loaded nanoemulgel (DLMGO-G)].

Language: Английский

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