Harnessing myeloid cells in cancer DOI Creative Commons
Suyeon Park, Ekaterina Pylaeva, Vikas Bhuria

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 6, 2025

Cancer-associated myeloid cells due to their plasticity play dual roles in both promoting and inhibiting tumor progression. Myeloid with immunosuppressive properties a critical role anti-cancer immune regulation. Cells of different origin, such as associated macrophages (TAMs), neutrophils (TANs), derived suppressor (also called MDSCs) eosinophils are often expanded cancer patients significantly influence survival, but also the outcome therapies. For this reason, variety preclinical clinical studies modulate activity these have been conducted, however without successful date. In review, pro-tumor cells, cell-specific therapeutic targets, vivo on cell re-polarization impact immunotherapies/genetic engineering addressed. This paper summarizes ongoing trials concept chimeric antigen receptor macrophage (CAR-M) therapies, suggests future research perspectives, offering new opportunities development novel treatment strategies.

Language: Английский

Nanomaterials in cancer immunotherapy: targeting cancer-associated fibroblasts DOI Creative Commons

Zhongsong Zhang,

Long Chen

Cancer Nanotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 17, 2025

Emphasizing the significance of cancer-associated fibroblasts (CAFs), non-malignant yet pivotal players within tumor microenvironment (TME), this review illuminates role inflammatory subtype (iCAF) as catalysts in cancer proliferation, metastasis, and therapeutic resistance. Given their paramount importance, targeting CAFs emerges a robust strategy evolving landscape immunotherapy. Nanomaterials, distinguished by unique features malleability, hold considerable promise biomedicine, especially precision-oriented domain therapy. Their aptitude for modulating immune responses, amplifying drug efficacy through precise delivery, discerningly focusing on cells TME situates nanomaterials formidable tools to transcend boundaries set conventional treatments. This scrutinizes convoluted interplay among CAFs, cells, TME. It further showcases widely utilized management. We underscore potential nanoscale delivery systems directed at underscoring transformative power revolutionizing therapies, enhancing precision, culminating improved patient outcomes.

Language: Английский

Citations

2
Harnessing myeloid cells in cancer DOI Creative Commons
Suyeon Park, Ekaterina Pylaeva, Vikas Bhuria

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 6, 2025

Cancer-associated myeloid cells due to their plasticity play dual roles in both promoting and inhibiting tumor progression. Myeloid with immunosuppressive properties a critical role anti-cancer immune regulation. Cells of different origin, such as associated macrophages (TAMs), neutrophils (TANs), derived suppressor (also called MDSCs) eosinophils are often expanded cancer patients significantly influence survival, but also the outcome therapies. For this reason, variety preclinical clinical studies modulate activity these have been conducted, however without successful date. In review, pro-tumor cells, cell-specific therapeutic targets, vivo on cell re-polarization impact immunotherapies/genetic engineering addressed. This paper summarizes ongoing trials concept chimeric antigen receptor macrophage (CAR-M) therapies, suggests future research perspectives, offering new opportunities development novel treatment strategies.

Language: Английский

Citations

0