International Journal of Applied Ceramic Technology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 31, 2024
Abstract
This
study
modifies
the
hydration
process
of
hydrated
magnesium
carboxylate
(HMC)
by
organic
acids
to
improve
workability
HMC‐bonded
castables
(HMCC),
while
comprehensively
analyzing
effects
on
mechanical
properties
and
thermal
shock
resistance
HMCC.
Results
demonstrate
that
lactic
acid
significantly
increases
setting
time
rheology
HMCC
738%
217.8%,
respectively.
is
due
inhibiting
HMC
ionization
delaying
hydration,
as
evidenced
kinetics
experiments.
Furthermore,
could
also
reduce
degree
polymerization
products.
Notably,
cold
modulus
rupture
593.7%,
100%,
95.7%
at
500°C,
800°C,
1100°C,
performance
improvement
attributed
acid's
promotion
sintering
HMCC,
possibly
its
effect
improving
castable
uniformity.
However,
results
in
an
18.1%
reduction
green
body
strength,
potentially
weakened
three‐dimensional
network
structure
Additionally,
residual
strength
ratio
4.3%
enhances
crack
propagation
(
R
‴)
45%.
These
improvements
result
from
optimized
microstructure,
characterized
smaller,
more
uniformly
distributed
particles
with
regular
shapes
tighter
interparticle
connections.
Crystals,
Journal Year:
2025,
Volume and Issue:
15(4), P. 350 - 350
Published: April 9, 2025
In
the
pharmaceutical
industry,
deep
eutectic
solvents
can
be
used
to
enhance
solubility,
permeability,
and
absorption
of
active
ingredients.
this
paper,
were
prepared
by
combining
ingredient
fosamprenavir
calcium
with
lactic
acid
in
certain
molar
ratios.
The
aim
study
was
create
a
therapeutic
solvent
same
effect
as
ingredient,
but
enhanced
properties.
1H
NMR
FTIR
spectroscopy
identify
characterize
chemical
composition
structural
changes
THEDES.
Maximum
release
from
solvent,
permeability
tested.
Different
mathematical
models
chosen
describe
kinetic
behavior
drug
release.
Processes,
Journal Year:
2025,
Volume and Issue:
13(4), P. 1141 - 1141
Published: April 10, 2025
Carvedilol
(CARV)
is
a
nonselective
beta
and
alpha-1
adrenoceptor
antagonist
commonly
indicated
for
chronic
heart
failure
hypertension.
Its
clinical
potential
limited
by
its
low
aqueous
solubility,
resulting
in
poor
bioavailability.
Encapsulation
of
CARV
cyclodextrins
(CDs)
was
performed
to
exceed
solubility-related
barriers.
This
study
examines
the
impact
CD
type
ethanol,
as
co-solvent
used
preparation
step,
on
complexation
with
two
β-CD
derivatives.
The
inclusion
complexes
(ICs)
were
prepared
employing
kneading
method
investigated
using
different
analytical
techniques,
including
thermoanalytical
methods,
powder
X-ray
diffractometry
(PXRD),
universal
attenuated
total
reflectance
Fourier
transform
infrared
(UATR-FTIR)
spectroscopy,
UV
spectroscopy
saturation
solubility
studies.
binary
products
heptakis(2,6-di-O-methyl)-β-cyclodextrin
(DM-β-CD)
randomly
methylated
β-cyclodextrin
(RM-β-CD)
exhibit
thermal
behavior,
FTIR
spectral
diffractometric
profiles
from
those
parent
compounds,
emphasizing
interaction
between
components
IC
formation.
increased
1.78
3.32
times
result
drug
CDs.
Analytical
data
indicate
significant
influence
both
solvent
systems
highlighting
CARV/DM-β-CD
promising
entity
further
research
obtain
new
formulations
containing
improved
Archiv der Pharmazie,
Journal Year:
2025,
Volume and Issue:
358(4)
Published: April 1, 2025
ABSTRACT
Hot
melt
extrusion
(HME)
technology
is
widely
used
in
pharmaceutical
drug
development
to
enhance
the
solubility
and
bioavailability
of
drugs.
Atorvastatin
(ATV)
a
first‐line
statin
for
preventing
cardiovascular
disease,
it
has
low
oral
(14%),
necessitating
strategies
improve
its
bioavailability.
This
study
involves
identifying
characterizing
interaction
degradation
products
formed
during
HME
process
involving
ATV
hydroxypropyl
methylcellulose
phthalate
(HPMCP‐55).
It
mainly
focuses
on
unknown
impurities
understanding
their
mechanisms.
A
simple,
efficient,
mass
spectrometry
compatible
high‐performance
liquid
chromatography
(HPLC)
method
was
developed
Welch
XB
C18
(4.6
×
150
mm,
3.5
μm)
column
using
gradient
elution
10
mM
ammonium
acetate
acetonitrile
as
mobile
phase.
Further,
attenuated
total
reflectance
infrared
spectrophotometry
(ATR‐IR)
also
employed
investigate
between
HPMCP‐55
(imp‐1,3)
(imp‐2,4)
process.
LC‐HRMS
ATR‐IR
analysis
confirmed
significant
drug–polymer
interactions
extrusion.
Plausible
impurity
structures
were
elucidated
via
MS/MS
fragmentation
patterns
accurate
mass.
In
silico
toxicity
prediction
performed
ProTox‐II
all
four
impurities.
The
underscores
importance
understand
stability,
safety,
efficacy.
comprehensive
approach
facilitates
thorough
potential
with
candidates
early
phase
development.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(9), P. 1909 - 1909
Published: April 25, 2025
The
physical
stability,
molecular
mobility,
and
appearance
of
nanocrystalline
resveratrol
in
a
polyvinylpyrrolidone
(PVP)
matrix
were
investigated.
Two
formulations
with
loadings
30%
50%
prepared
characterized
using
powder
X-ray
diffraction
(PXRD)
time-domain
nuclear
magnetic
resonance
(TD-NMR).
Samples
studied
over
time
(up
to
300
days
post-preparation),
across
temperatures
(80–300
K),
under
varying
humidity
conditions
(0%
75%
relative
humidity).
results
demonstrate
that
the
resveratrol–PVP
sample
is
homogeneous
amorphous
solid
dispersion
(ASD),
while
contained
nanocrystals
measuring
about
40
nm.
NMR
measurements
dynamics
(MD)
simulations
revealed
incorporation
into
polymer
modifies
system’s
mobility
compared
pure
PVP
polymer.
Additionally,
MD
analyzed
hydrogen
bonding
network
within
system,
providing
insights
for
better
understanding
stability
ASD
different
conditions.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(11), P. 1368 - 1368
Published: Oct. 25, 2024
Amorphization
of
an
active
pharmaceutical
ingredient
(API)
can
improve
its
dissolution
and
enhance
bioavailability.
Avoiding
solvents
for
drug
amorphization
is
beneficial
due
to
environmental
issues
potential
solvent
residues
in
the
final
product.
