Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure

Psychopharmacology, Journal Year: 2006, Volume and Issue: 189(1), P. 1 - 16

Published: Sept. 22, 2006

Language: Английский

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Neurobiology of the incubation of drug craving

Trends in Neurosciences, Journal Year: 2011, Volume and Issue: 34(8), P. 411 - 420

Published: July 24, 2011

Language: Английский

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Arousal and reward: a dichotomy in orexin function

Trends in Neurosciences, Journal Year: 2006, Volume and Issue: 29(10), P. 571 - 577

Published: Aug. 15, 2006

Language: Английский

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Reward system and addiction: what dopamine does and doesn’t do

Current Opinion in Pharmacology, Journal Year: 2006, Volume and Issue: 7(1), P. 69 - 76

Published: Dec. 16, 2006

Language: Английский

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Neuroplasticity in the mesolimbic dopamine system and cocaine addiction

British Journal of Pharmacology, Journal Year: 2008, Volume and Issue: 154(2), P. 327 - 342

Published: March 17, 2008

The main characteristics of cocaine addiction are compulsive drug use despite adverse consequences and high rates relapse during periods abstinence. A current popular hypothesis is that due to drug-induced neuroadaptations in reward-related learning memory processes, which cause hypersensitivity cocaine-associated cues, impulsive decision making abnormal habit-like learned behaviours insensitive consequences. Here, we review results from studies on the effect exposure selected signalling cascades, growth factors physiological processes previously implicated neuroplasticity underlying normal memory. These include extracellular signal-regulated kinase (ERK) pathway, brain-derived neurotrophic factor (BDNF), glutamate transmission, synaptic plasticity (primarily form long-term potentiation depression, LTP LTD). We also discuss degree these cocaine-induced changes mesolimbic dopamine system mediate psychomotor sensitization cocaine-seeking behaviours, as assessed animal models addiction. Finally, speculate how may interact initiate sustain seeking.

Language: Английский

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A unified framework for addiction: Vulnerabilities in the decision process

Behavioral and Brain Sciences, Journal Year: 2008, Volume and Issue: 31(4), P. 415 - 437

Published: July 29, 2008

Abstract The understanding of decision-making systems has come together in recent years to form a unified theory the mammalian brain as arising from multiple, interacting (a planning system, habit and situation-recognition system). This system multiple potential access points through which it can be driven make maladaptive choices, particularly choices that entail seeking certain drugs or behaviors. We identify 10 key vulnerabilities system: (1) moving away homeostasis, (2) changing allostatic set points, (3) euphorigenic “reward-like” signals, (4) overvaluation (5) incorrect search situation-action-outcome relationships, (6) misclassification situations, (7) (8) mismatch balance two decision systems, (9) over-fast discounting processes, (10) changed learning rates. These provide taxonomy problems with systems. Although each vulnerability drive an agent return addictive choice, also implies characteristic symptomology. Different drugs, different behaviors, individuals are likely vulnerabilities. implications for individual's susceptibility addiction transition addiction, relapse, treatment.

Language: Английский

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Context-induced relapse to drug seeking: a review

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2008, Volume and Issue: 363(1507), P. 3233 - 3243

Published: July 18, 2008

In humans, exposure to environmental contexts previously associated with drug intake often provokes relapse use, but the mechanisms mediating this are unknown. Based on early studies by Bouton & Bolles context-induced 'renewal' of learned behaviours, we developed a procedure study seeking. procedure, rats first trained self-administer in one context. Next, drug-reinforced lever responding is extinguished different (non-drug) Subsequently, reinstatement seeking assessed re-exposing drug-associated Using variations and others reported reliable history heroin, cocaine, heroin-cocaine combination, alcohol nicotine self-administration. Here, discuss potential psychological reinstatement, including excitatory inhibitory Pavlovian conditioning, occasion setting. We then summarize results from pharmacological neuroanatomical role several neurotransmitter systems (dopamine, glutamate, serotonin opioids) brain areas (ventral tegmental area, accumbens shell, dorsal striatum, basolateral amygdala, prefrontal cortex, hippocampus lateral hypothalamus) reinstatement. conclude discussing clinical implications rat

Language: Английский

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Role of Corticotropin-Releasing Factor in Drug Addiction

CNS Drugs, Journal Year: 2011, Volume and Issue: 25(4), P. 271 - 287

Published: March 23, 2011

Language: Английский

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Opiate versus psychostimulant addiction: the differences do matter

Nature reviews. Neuroscience, Journal Year: 2011, Volume and Issue: 12(11), P. 685 - 700

Published: Oct. 5, 2011

Language: Английский

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Cellular neuroadaptations to chronic opioids: tolerance, withdrawal and addiction

British Journal of Pharmacology, Journal Year: 2008, Volume and Issue: 154(2), P. 384 - 396

Published: April 14, 2008

A large range of neuroadaptations develop in response to chronic opioid exposure and these are thought be more or less critical for expression the major features addiction: tolerance, withdrawal processes that may contribute compulsive use relapse. This review considers adaptations at different levels organization nervous system including tolerance mu-opioid receptor itself, cellular opioid-sensitive neurons, systems nerve networks, as well synaptic plasticity sensitive networks. Receptor appears involve enhancement mechanisms regulation, desensitization internalization. Adaptations causing complex but several important have been identified upregulation cAMP/PKA cAMP element-binding signalling perhaps mitogen activated PK cascades neurons might not only influence also during cycles intoxication withdrawal. The potential complexity network, interact with is great some candidate neuropeptide play a role withdrawal, activation glial signalling. Implication forms learning such long term potentiation depression addiction still its infancy this ultimately has identify specific synapses

Language: Английский

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