Magnesium: Biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency

Nutrients, Journal Year: 2021, Volume and Issue: 13(4), P. 1136 - 1136

Published: March 30, 2021

Magnesium plays an important role in many physiological functions. Habitually low intakes of magnesium and general the deficiency this micronutrient induce changes biochemical pathways that can increase risk illness and, particular, chronic degenerative diseases. The assessment status is consequently great importance, however, its evaluation difficult. measurement serum concentration most commonly used readily available method for assessing status, even if levels have no reliable correlation with total body or concentrations specific tissues. Therefore, review offers overview recent insights into from multiple perspectives. Starting a point view, it aims at highlighting due to insufficient uptake (frequently content modern western diet), suggesting strategies reach recommended dietary reference values, focusing on importance detecting pathological various districts, order counteract social impact diseases linked deficiency.

Language: Английский

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‘Magnesium’-the master cation-as a drug—possibilities and evidences

BioMetals, Journal Year: 2021, Volume and Issue: 34(5), P. 955 - 986

Published: July 2, 2021

Language: Английский

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Magnesium in Infectious Diseases in Older People

Nutrients, Journal Year: 2021, Volume and Issue: 13(1), P. 180 - 180

Published: Jan. 8, 2021

Reduced magnesium (Mg) intake is a frequent cause of deficiency with age together reduced absorption, renal wasting, and polypharmacotherapy. Chronic Mg may result in increased oxidative stress low-grade inflammation, which be linked to several age-related diseases, including higher predisposition infectious diseases. might play role the immune response being cofactor for immunoglobulin synthesis other processes strictly associated function T B cells. necessary biosynthesis, transport, activation vitamin D, another key factor pathogenesis The regulation cytosolic free cells involves transport systems, such as melastatin-like transient receptor potential 7 channel, solute carrier family, transporter 1 (MAGT1). functional importance immunity was unknown until description primary immunodeficiency XMEN (X-linked defect, Epstein–Barr virus infection, neoplasia) due genetic MAGT1 characterized by chronic infection. This research reporting associations deficit viral bacterial infections indicate possible recent coronavirus disease 2019 (COVID-19) its complications. In this review, we will discuss system pandemic COVID-19.

Language: Английский

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Magnesium as an Important Factor in the Pathogenesis and Treatment of Migraine—From Theory to Practice

Nutrients, Journal Year: 2022, Volume and Issue: 14(5), P. 1089 - 1089

Published: March 5, 2022

So far, no coherent and convincing theory has been developed to fully explain the pathogenesis of migraine, although many researchers experts emphasize its association with spreading cortical depression, oxidative stress, vascular changes, nervous excitement, neurotransmitter release, electrolyte disturbances. The contribution magnesium deficiency induction depression or abnormal glutamatergic neurotransmission is a likely mechanism magnesium-migraine relationship. Hence, there interest in various methods assessing ion attempts study relationship intra- extracellular levels migraine attacks. At same time, clinicians believe that supplementation right dose form can be treatment prevent attacks, especially those patients who have identified contraindications standard medications their different preferences. However, are reliable publications confirming role diet as factor causing It also seems interesting deepen research on administration high doses intravenously during aim was discuss probable mechanisms correlation well present current clinical proposals for use preparations complementary substitute pharmacotherapy migraine. summary results observations date gives hope finding trigger attacks (especially aura), which may turn out easy diagnose eliminate pharmacological dietary supplementation.

Language: Английский

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A Review on Measures to Rejuvenate Immune System: Natural Mode of Protection Against Coronavirus Infection

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: March 15, 2022

SARS-CoV-2, a novel Corona virus strain, was first detected in Wuhan, China, December 2019. As of 16, 2021, almost 4,822,472 people had died and over 236,132,082 were infected with this lethal viral infection. It is believed that the human immune system thought to play critical role initial phase infection when viruses invade host cells. Although some effective vaccines have already been on market, researchers many bio-pharmaceuticals are still working hard develop fully functional vaccine or more therapeutic agent against COVID-19. Other efforts, addition vaccines, can help strengthen defeat corona Herein, we reviewed those proven measures, following which efficient be better prepared fight Among these, dietary supplements like- fresh vegetables fruits offer plentiful vitamins antioxidants, enabling build healthy system. While pharmacologically active components medicinal plants directly aid fighting infection, supplementary combined diet will assist regulate prevent In addition, personal habits, regular physical exercise, intermittent fasting, adequate sleep, also becoming an one. Maintaining each these system, allowing innate immunity become defensive antagonistic mechanism corona-virus However, because treatments take longer produce beneficial effects adaptive maturation, personalized nutrition cannot expected immediate impact global outbreak.

Language: Английский

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Carboxylates as green corrosion inhibitors of magnesium alloy for biomedical application

Journal of Magnesium and Alloys, Journal Year: 2024, Volume and Issue: 12(7), P. 2909 - 2936

Published: July 1, 2024

Language: Английский

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Molecular mechanisms and therapeutic effects of different vitamins and minerals in COVID-19 patients

Journal of Trace Elements in Medicine and Biology, Journal Year: 2022, Volume and Issue: 73, P. 127044 - 127044

Published: July 20, 2022

Language: Английский

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Glutathione deficiency in the pathogenesis of SARS-CoV-2 infection and its effects upon the host immune response in severe COVID-19 disease

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 6, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes disease 19 (COVID-19) has numerous risk factors leading to severe with high mortality rate. Oxidative stress excessive production of reactive oxygen species (ROS) lower glutathione (GSH) levels seems be a common pathway associated the COVID-19 mortality. GSH is unique small but powerful molecule paramount for life. It sustains adequate redox cell signaling since physiologic level oxidative fundamental controlling life processes via signaling, oxidation and tissue damage. The water-soluble tripeptide (γ-L-glutamyl-L-cysteinyl-glycine) present in cytoplasm all cells. at 1–10 mM concentrations mammalian tissues (highest concentration liver) as most abundant non-protein thiol protects against stress. also activates Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related (Nrf2)-antioxidant response element (ARE) regulator pathway, releasing Nrf2 regulate expression genes control antioxidant, inflammatory immune system responses, facilitating activity. exists thiol-reduced disulfide-oxidized (GSSG) forms. Reduced prevailing form accounting >98% total GSH. GSSG their molar ratio are indicators functionality its alteration related various human pathological including COVID-19. plays prominent role SARS-CoV-2 infection following recognition viral S-protein by angiotensin converting enzyme-2 receptor pattern receptors like toll-like 4, activation transcription nuclear kappa B, subsequently activate nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) succeeded ROS production. depletion may have pathophysiology, host severity Therapies enhancing could become cornerstone reduce fatal outcomes increasing prevent subdue disease. value makes research field biology medicine key

Language: Английский

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Nutraceuticals and Dietary Supplements for Older Adults with Long COVID-19

Clinics in Geriatric Medicine, Journal Year: 2022, Volume and Issue: 38(3), P. 565 - 591

Published: June 20, 2022

Language: Английский

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Importance of Magnesium Status in COVID-19

Biology, Journal Year: 2023, Volume and Issue: 12(5), P. 735 - 735

Published: May 18, 2023

A large amount of published research points to the interesting concept (hypothesis) that magnesium (Mg) status may have relevance for outcome COVID-19 and Mg could be protective during COVID disease course. As an essential element, plays basic biochemical, cellular, physiological roles required cardiovascular, immunological, respiratory, neurological functions. Both low serum dietary been associated with severity outcomes, including mortality; both are also risk factors such as older age, obesity, type 2 diabetes, kidney disease, cardiovascular hypertension, asthma. In addition, populations high rates mortality hospitalization tend consume diets in modern processed foods, which generally Mg. this review, we review describe consider possible impact on showing (1) between 2.19 2.26 mg/dL intakes > 329 mg/day course (2) inhaled improve oxygenation hypoxic patients. spite promise, oral has thus far studied only combination other nutrients. deficiency is involved occurrence aggravation neuropsychiatric complications COVID-19, memory loss, cognition, loss taste smell, ataxia, confusion, dizziness, headache. Potential zinc and/or useful increasing drug therapy effectiveness or reducing adverse effect anti-COVID-19 drugs reviewed. Oral trials patients warranted.

Language: Английский

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