Development and validation of stability indicating RP-HPLC method for the estimation of azilsartan in Bulk DOI Open Access

K. Mounika,

M. P. Nageswarrao,

Yogindra Kumari

et al.

International Journal of Health Sciences, Journal Year: 2022, Volume and Issue: unknown, P. 7695 - 7707

Published: July 7, 2022

Angiotensin-receptor blockers are often considered adequately efficacious in reducing blood pressure. By accepting the current regulatory requirements for an analytical method development, a reversed phase high performance liquid chromatographic routine analysis of Azilsartan has been developed. The optimized was achieved using unisol C-18 (3μm, 4.6×150mm) coloumn with mobile consisting mixture acetonitrile and methonal (90:10v/v) flow rate 0.8ml/min at 249nm. Linear concentration range is 2-10μg/ml. detection quantitation limit found to be 0.45μg/ml. And 0.149μg/ml. There no interfering peaks under performed degradation conditions. validated according ICH guidelines.

Language: Английский

Association between 25-hydroxy vitamin D, interleukin-4, and interferon-γ levels and asthma in children with Mycoplasma pneumonia infection DOI Creative Commons
Tao Shen, Tingting Liu,

Luke Kong

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 21, 2024

Abstract To explore the association between 25-hydroxy vitamin D [25-(OH)-D], interleukin-4 (IL-4), and interferon-γ (IFN-γ) in children with Mycoplasma pneumoniae (MP) infection-related asthma. Logistic analysis was conducted to compare general data MP asthma non-asthma groups. The level of 25-(OH)-D, IL-4, IFN-γ were detected compared Moreover, receiver operating characteristic curve (ROC) applied test predictive value each variable. results logistic regression demonstrated that recurrent upper respiratory tract infections collective living are related incidence infection whether or without IL-4 group significantly higher than those control ( p < 0. 05), whilst 25-(OH)-D IFN-γ/IL-4 lower 05). ROC curves indicated area under (AUC) IFN-γ, IFN-γ/IL-4, joint detection 0.765, 0.780, 0.853, 0.638, 0.912 diagnosis asthma, sensitivity specificity both greater 95%. For is upregulated, while downregulated. may improve diagnostic capabilities

Language: Английский

Citations

0

None DOI Creative Commons

Irad Mwendo,

Patrick Kinyua Gikunda,

Anthony Maina

et al.

COVID Research Open Access, Journal Year: 2023, Volume and Issue: 1(1)

Published: Nov. 28, 2023

Chest X-rays remains to be the most common imaging modality used diagnose lung diseases.However, they necessitate interpretation of experts (radiologists and pulmonologists), who are few.This review paper investigates use deep transfer learning techniques detect pneumonia, images.It provides an overview current state-of the-art CXR image classification discusses challenges opportunities in applying this domain.The a thorough examination recent research studies that algorithms for COVID-19, tuberculosis detection, highlighting advantages disadvantages these approaches.Finally, future directions field classification, as well potential aid diagnosis treatment diseases.

Language: Английский

Citations

0

Development and validation of stability indicating RP-HPLC method for the estimation of azilsartan in Bulk DOI Open Access

K. Mounika,

M. P. Nageswarrao,

Yogindra Kumari

et al.

International Journal of Health Sciences, Journal Year: 2022, Volume and Issue: unknown, P. 7695 - 7707

Published: July 7, 2022

Angiotensin-receptor blockers are often considered adequately efficacious in reducing blood pressure. By accepting the current regulatory requirements for an analytical method development, a reversed phase high performance liquid chromatographic routine analysis of Azilsartan has been developed. The optimized was achieved using unisol C-18 (3μm, 4.6×150mm) coloumn with mobile consisting mixture acetonitrile and methonal (90:10v/v) flow rate 0.8ml/min at 249nm. Linear concentration range is 2-10μg/ml. detection quantitation limit found to be 0.45μg/ml. And 0.149μg/ml. There no interfering peaks under performed degradation conditions. validated according ICH guidelines.

Language: Английский

Citations

0