Deleted Journal,
Journal Year:
2024,
Volume and Issue:
1(1)
Published: July 21, 2024
Abstract
Aromatic
natural
products
are
important
for
improving
human
health
and
quality
of
life.
Large-scale
availability
these
compounds
from
plants
is
limited
by
low
yield
cumbersome
extraction.
Building
high-performance
microbial
cell
factories
to
produce
aromatic
means
metabolic
engineering
synthetic
biology
a
viable
option.
In
the
context
climate
change
global
resource
scarcity,
choosing
solar-powered
carbon-fixing
cyanobacteria
instead
chemical
heterotrophic
microorganisms
might
be
more
progressive
better
solution.
this
review,
we
summarize
principal
strategies
production
in
engineered
cyanobacteria,
including
regulation
metabolism,
optimization
pathway,
culture
process
development,
cooperation,
highlighting
potential
microbe
as
novel
chassis
cell.
Natural Product Reports,
Journal Year:
2022,
Volume and Issue:
40(5), P. 988 - 1021
Published: Oct. 7, 2022
This
review
summarizes
the
applications
of
late-stage
strategies
in
direct
trifluoromethylation
natural
products
past
ten
years,
with
particular
emphasis
on
reaction
model
each
method.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(19), P. 4534 - 4534
Published: Sept. 24, 2024
Quorum
sensing
(QS)
is
a
bacterial
cell-to-cell
communication
mechanism
that
plays
an
essential
role
in
pathogenesis.
QS
governs
behavior
and
controls
biofilm
formation,
which
turn
contributes
to
antibiotic
resistance.
Therefore,
identifying
synthesizing
novel
compounds
overcome
inhibit
formation
are
essential.
Coumarins
important
plant-derived
natural
products
with
wide-ranging
bioactivities
extensive
applications,
including
antibacterial,
antifungal,
anticoagulant,
antioxidant,
anticancer,
anti-inflammatory
properties.
Additionally,
coumarins
capable
of
rewiring
inhibition,
leading
higher
susceptibility
antimicrobial
agents
less
this
review,
we
aim
provide
overview
formation.
This
review
also
discusses
the
synthesized
controlling
QS,
inhibiting
inducing
synergy
antibiotic–coumarin
combinations.
Hence,
emphasizes
potential
coumarin
act
as
antibacterial
demonstrates
their
ability
alleviate
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(27)
Published: July 16, 2024
Abstract
Molecular
dynamics
(MD)
simulation
is
an
in
silico
method
used
the
biomolecular
level
of
research
to
study
how
protein
interacts
with
target
time.
It
provides
a
detailed
information
and
ligand
structure
crucial
amino
acid
interactions.
Monoamine
oxidase
B
(MAO−B)
isoenzyme
responsible
for
catalyses
oxidative
deamination
various
biogenic
amines
brain
peripheral
tissues.
The
selective
inhibitors
MAO−B
are
considered
as
management
symptoms
neurodegenerative
disorders
like
Alzheimer's
disease(AD)
Parkinson
disease(PD).
Recently
structural
scaffolds
containing
chalcones,
coumarins
chromones
derived
candidates
shown
potent,
selective,
competitive
reversible
type
inhibitors.
similarities
between
above
can
produce
almost
similar
interactions
inhibitor
binding
cavity
MAO−B.
Numerous
molecular
reports
were
supported
by
mentioned
fact.
current
review
focus
on
last
ten
year
report
towards
inhibition.
also
focuses
software
details
MD
requirement
from
each
class
compound
recognition
inhibitory
activity.
The
aerial
parts
of
Paederia
scandens
(Lour.)
Merr.
were
extracted
with
water
and
the
extract
was
isolated
purified
through
systematic
chromatographic
separation.
Twenty-one
coumarins,
including
six
previously
undescribed
ones,
obtained.
Their
structures
elucidated
based
on
comprehensive
analyses
NMR,
HR-ESI-MS,
ECD
data.
anti-neuroinflammatory
activities
compounds
evaluated
using
an
LPS-induced
neuroinflammation
model
in
BV-2
microglia
cells.
Fraxin
methyl
ether
(2)
exhibited
notable
inhibitory
effects,
IC50
values
17.07
±
2.88
μM.
Moreover,
further
mechanistic
studies
compound
2
revealed
that
it
could
block
nuclear
translocation
NF-
κB
reduce
expression
iNOS,
COX-2,
IL-1β
IL-6,
exerting
effects.
These
findings
provide
a
solid
foundation
for
development
utilization
P.
as
natural
source
potential
agents.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(1), P. 375 - 375
Published: Jan. 4, 2025
Previously
we
discovered
that
among
15
DNA-binding
plant
secondary
metabolites
(PSMs)
possessing
anticancer
activity,
11
compounds
cause
depletion
of
the
chromatin-bound
linker
histones
H1.2
and/or
H1.4.
Chromatin
remodeling
or
multiH1
knocking-down
is
known
to
promote
upregulation
repetitive
elements,
ultimately
triggering
an
interferon
(IFN)
response.
Herein,
using
HeLa
cells
and
applying
fluorescent
reporter
assay
with
flow
cytometry,
immunofluorescence
staining
quantitative
RT-PCR,
studied
effects
PSMs
both
evicting
from
chromatin
not
influencing
their
location
in
nucleus.
We
found
(1)
8
PSMs,
histone
chromatin,
activated
significantly
type
I
IFN
signaling
pathway
out
these
resveratrol,
berberine,
genistein,
delphinidin,
naringenin
curcumin
also
caused
LINE1
expression.
Fisetin
quercetin,
which
induced
eviction
only
signaling,
but
expression;
(2)
curcumin,
sanguinarine
kaempferol,
causing
significant
H1.4
presence
activate
less
intensively
without
any
changes
(3)
four
did
eviction,
displayed
neither
activation
nor
enhancement
Thus,
have
shown
for
first
time
destabilization
observed
by
accompanied
expression
often
impacts
this
activation.
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 15, 2025
Wool
is
the
most
widely
used
proteinic
natural
fiber
in
clothing
industry
by
virtue
of
its
versatile
properties.
Unfortunately,
wool,
as
a
fiber,
more
susceptible
to
attack
microorganisms
and
moths,
which
may
cause
harm
human
health.
That
why
antimicrobial
mothproof
finishing
textiles
prime
importance
textile
industry.
Herein,
wool
fabric
was
treated
with
synthesized
6-aminocoumarin
adopting
pad-dry-cure
technique
or
without
cross-linker.
The
evaluated
for
activity
against
Staphylococcus
aureus
Escherichia
coli.
also
tested
moth-proofing
performance
Tineola
Bisselliella
through
assessing
weight
loss.
Various
analyses
were
conducted
assign
alteration
structure
fibers,
viz.,
urea-bisulfite
solubility,
carboxylic
content,
Fourier
transform
infrared
spectroscopy,
X-ray
diffraction
pattern
(XRD).
Scanning
electron
microscopy
displayed
surface
before
after
treatment.
Some
physical
mechanical
properties
assessed.
Results
revealed
that
showed
bacterial
resistance
Gram
+ve
−ve
bacteria,
addition
improved
moth
larvae
deterioration
fabric's
inherent
