Therapeutic mechanisms of psychedelics and entactogens

Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 49(1), P. 104 - 118

Published: July 24, 2023

Language: Английский

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MDMA enhances empathy-like behaviors in mice via 5-HT release in the nucleus accumbens

Science Advances, Journal Year: 2024, Volume and Issue: 10(17)

Published: April 24, 2024

MDMA (3,4-methylenedioxymethamphetamine) is a psychoactive drug with powerful prosocial effects. While sometimes termed an "empathogen," empirical studies have struggled to clearly demonstrate these effects or pinpoint underlying mechanisms. Here, we paired the social transfer of pain and analgesia-behavioral tests modeling empathy in mice-with region-specific neuropharmacology, optogenetics, transgenic manipulations explore MDMA's action as empathogen. We report that MDMA, given intraperitoneally infused directly into nucleus accumbens (NAc), robustly enhances analgesia. Optogenetic stimulation 5-HT release NAc recapitulates implicating signaling core mechanism. Last, systemic optogenetic inputs restores deficits empathy-like behaviors

Language: Английский

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Nicotine enhances object recognition memory through activation of the medial prefrontal cortex to the perirhinal cortex pathway

Neurochemistry International, Journal Year: 2025, Volume and Issue: unknown, P. 105963 - 105963

Published: March 1, 2025

Language: Английский

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Chronic nicotine enhances object recognition memory via inducing long-term potentiation in the medial prefrontal cortex in mice

Neuropharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 110435 - 110435

Published: March 1, 2025

Language: Английский

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Role of medial prefrontal cortex voltage-dependent potassium 4.3 channels in nicotine-induced enhancement of object recognition memory in male mice

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 978, P. 176790 - 176790

Published: June 27, 2024

Language: Английский

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Neural circuits and therapeutic mechanisms of empathic pain

Neuropharmacology, Journal Year: 2024, Volume and Issue: 265, P. 110268 - 110268

Published: Dec. 12, 2024

Language: Английский

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From rodents to humans: Rodent behavioral paradigms for social behavioral disorders

Brain Circulation, Journal Year: 2023, Volume and Issue: 9(3), P. 154 - 161

Published: July 1, 2023

Abstract Social cognition guides social behavior. Subjects with proper should be able to: (1) have reasonable motivation, (2) recognize other people and infer their intentions, (3) weigh hierarchies values. The choice of appropriate behavioral paradigms enables the use rodents to study behavior disorders in humans, thus enabling research go deeper into neural mechanisms. This paper reviews commonly used rodent studies disorders. We focused specifically on sorting out ways transfer human through paradigms.

Language: Английский

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5-HT2C receptors in the nucleus accumbens constrain the rewarding effects of MDMA

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

ABSTRACT MDMA is a promising adjunct to psychotherapy and has well-known abuse liability, although less than other amphetamine analogs. While the reinforcing dopamine (DA)-releasing properties of are on par with methamphetamine (METH), far more potent serotonin (5-HT) releaser, via 5-HT transporter (SERT). MDMA-mediated release in major reward center, nucleus accumbens (NAc), drives prosocial behaviors 5-HT1BR activation. We hypothesized that this mechanism contributes reduced compared METH used platform assays predict balance abuse-linked effects (R)-MDMA, novel entactogen clinical development. NAc DA release, measured by GRAB-DA photometry vivo, increased proportion (7.5 15 mg/kg, i.p.) (2 mg/kg i.p.)-conditioned place preference (CPP). Using conditional knockouts (cKOs) for DAT SERT, microdialysis, photometry, we found MDMA-released limited through actions NAc, rather at ventral tegmental area DAergic cell bodies. SERT cKO dose required CPP three-fold. This enhanced MDMA-CPP were replicated intra-NAc infusion either reuptake inhibitor (escitalopram) prevent interaction or 5-HT2CR antagonist (SB242084), but not NAS-181. These data support separate mechanisms low potential versus effect MDMA. assays, (R)-MDMA predicted have potential.

Language: Английский

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Activation of ventral pallidum-projecting neurons in the nucleus accumbens via 5-HT2C receptor stimulation regulates motivation for wheel running in male mice

Neuropharmacology, Journal Year: 2024, Volume and Issue: 261, P. 110181 - 110181

Published: Oct. 10, 2024

Language: Английский

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Effects of 3,4‐methylenedioxymethamphetamine on neural activity in the nucleus accumbens of male mice engaged in social behavior

Neuropsychopharmacology Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Abstract 3,4‐methylenedioxymethamphetamine (MDMA), a commonly abused recreational drug, induces prosocial effects such as increased sociability and empathy. The nucleus accumbens (NAc) has been suggested to play crucial role in these MDMA‐mediated effects. However, the relationship between social behavior NAc neural activity, of MDMA on this relationship, remain unknown. In study, we measured activity using fiber photometry classified behaviors mice at times transient increases during approach test (SAT). We found that transiently onset turning toward sniffing novel SAT, although frequency was relatively low. then examined decreased duration per bout but did not alter or mice. These results suggest does affect increase behaviors.

Language: Английский

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