Recent trends in ginseng research

Journal of Natural Medicines, Journal Year: 2024, Volume and Issue: 78(3), P. 455 - 466

Published: March 21, 2024

Language: Английский

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GABAFG isolated fom ginseng ameliorates type 2 diabetes mellitus by modulating gut microbiota and autophagy-lysosome pathway

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Hyperglycemia and hyperlipidemia are the hallmarks of type 2 diabetes mellitus (T2DM). T2DM is a systemic metabolic disease caused by insulin resistance malfunctioning pancreatic β-cells. Although ginseng (the roots Panax C.A. Meyer) can be used to treat T2DM, underlying mechanism unclear. To assess role of, γ-aminobutyric acid-fructosyl-glucose (GABAFG), maillard reaction product ginseng, in treatment. The metabolism GABAFG serum tissues was analyzed via ultra-high performance liquid chromatography-Q exactive-mass spectrometry (UHPLC-QE-MS). molecular mechanisms β-cells (in vivo vitro) were investigated Western blotting, qPCR immunofluorescence. In addition, results validated high-throughput sequencing metabolomics. alleviated elevation blood glucose lipids HFD/STZ-induced mice. Also, reduced resistance-associated IRS-1 signaling axis vitro. Mechanistically, targeted nuclear translocation TFEB inhibited apoptosis enhancing autophagolysosome function. remodeled gut microbiota. Specifically, increased Akkermansia, decreased Romboutsia abundance, glycerophospholipid metabolism, thus alleviating T2DM-induced dyslipidemia. This first study pharmacological effects ginseng-derived T2DM. Therefore, this provides new theoretical basis for understanding effect diseases.

Language: Английский

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Ginseng in Delaying Brain Aging: Progress and perspectives

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156587 - 156587

Published: March 1, 2025

Language: Английский

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Comparative Study of Ginsenoside Rg2, 20(S)-protopanaxatriol, and AFG from Ginseng on Aging-related Kidney Injury in SAMP8 Mice

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119807 - 119807

Published: April 1, 2025

Language: Английский

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Isobicyclogermacrenal ameliorates hippocampal ferroptosis involvement in neurochemical disruptions and neuroinflammation induced by sleep deprivation in rats

Phytomedicine, Journal Year: 2024, Volume and Issue: 136, P. 156306 - 156306

Published: Nov. 29, 2024

Language: Английский

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Protective Effect of Que Zui Tea on d-Galactose-Induced Oxidative Stress Damage in Mice via Regulating SIRT1/Nrf2 Signaling Pathway

Molecules, Journal Year: 2024, Volume and Issue: 29(6), P. 1384 - 1384

Published: March 20, 2024

Que Zui tea (QT) is an important herbal in the diet of ‘Yi’ people, ethnic group China, and it has shown significant antioxidant, anti-inflammatory, hepatoprotective effects vitro. This study aims to explore protective aqueous-ethanol extract (QE) taken from QT against ᴅ-galactose (ᴅ-gal)-induced oxidative stress damage mice its potential mechanisms. QE was identified as UHPLC-HRMS/MS for chemical composition possible bioactive substances. Thus, rich phenolic flavonoid compounds. Twelve compounds were identified, main components which chlorogenic acid, quinic 6′-O-caffeoylarbutin. Histopathological biochemical analysis revealed that significantly alleviated brain, liver, kidney ᴅ-gal-treated mice. Moreover, remarkably attenuated by activating Nrf2/HO-1 pathway increase expression antioxidant indexes, including GSH, GSH-Px, CAT, SOD, T-AOC. In addition, administration could inhibit IL-1β IL-6 levels, suppress inflammatory response. noticeably alleviate apoptosis inhibiting expressions Caspase-3 Bax proteins brains, livers, kidneys The anti-apoptosis mechanism may be related upregulation SIRT1 protein downregulation p53 induced tissues Molecular docking demonstrated QE, 6′-O-caffeoylarbutin, robustaside A, had good binding ability with Nrf2 proteins. present indicated ᴅ-gal-induced liver cell apoptosis; additionally, associated SIRT1/Nrf2 signaling pathway.

Language: Английский

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The Comparative Effects Between Long‐Term and Short‐Term Treatment of Finasteride on Anxiety‐Like and Depression‐Like Behaviors in Early Senescent Male Rats

Journal of Neuroscience Research, Journal Year: 2024, Volume and Issue: 102(10)

Published: Oct. 1, 2024

ABSTRACT This study aims to compare the efficacy of 5‐alpha‐reductase inhibitors (5ARIs) on anxiety and depression between long‐term short‐term treatment followed by withdrawal in d ‐galactose (Dgal)–induced senescent male rats. Thirty‐two, 8‐week‐old, Wistar rats were divided into two groups: control Dgal‐treated (150 mg/kg/day; subcutaneously) for 18 weeks. At week 13, subdivided three subgroups: (1) vehicle (DgV), (2) with 5ARIs, Finasteride 5 mg/kg/day, per oral 6 weeks (DgF), (3) 2 a 4‐week period (DgW). Anxiety assessed using elevated‐plus maze (EPM) splash test (ST). Blood was collected biochemical analysis. After euthanasia, brains removed examine brain inflammation, oxidative stress, neuroactive steroids, metabolites, markers. We found that DgV exhibited metabolic disturbance reduced preference index EPM, grooming duration ST. Increased neurotoxic along increased inflammation/oxidative microglia complexity observed Both therapeutic approaches improved parameters open arm EPM rats, while only DgF Our results indicate Fin reduces depression‐like anxiety‐like behaviors reducing senescent. In conclusion, 5ARIs is more effective alleviating than Dgal‐induced early

Language: Английский

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Research Progress of Maillard Reaction and its Application in Processing of Traditional Chinese Medicine

Natural Product Communications, Journal Year: 2024, Volume and Issue: 19(11)

Published: Nov. 1, 2024

The Maillard reaction, also known as the ‘non-enzymatic browning reaction’, involves a reaction between reducing sugars and amino compounds, including acids proteins. has been increasingly used in production of traditional Chinese medicine food. This study thoroughly examines mechanism factors that influence it techniques for extracting, separating purifying products (MRPs) food processing. Additionally, article explores physiological functions MRPs, highlighting their antioxidant, hepato-protective, antibacterial, immune-boosting, anti-mutagenic, anti-inflammatory, health-promoting, detoxifying antiviral effects. MRPs have diverse outcomes because various influencing factors; they can contain trace amounts potentially harmful constituents, such acrylamide, 5-hydroxymethylfurfural advanced glycosylation products. includes comparative analysis common methods separation purification concentrated MRPs. These consist ultrafiltration, macroporous resin, gel chromatography, ion exchange chromatography dialysis. Results indicate each method advantages disadvantages, thus careful consideration should be placed on specific applications. Furthermore, future outlook research development its is proposed. Given activities are diverse, thorough qualitative quantitative mechanisms, pharmacologically active ingredients needed. offers valuable insights into advancement industries involved medicinal material effectively utilised healthcare clinical practice, offering innovative ideas scientific technological professionals development.

Language: Английский

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Non-saponin from Panax ginseng maintains blood-brain barrier integrity by inhibiting NF-κB and p38 MAP kinase signaling pathways to prevent the progression of experimental autoimmune encephalomyelitis

Journal of Ginseng Research, Journal Year: 2024, Volume and Issue: 49(1), P. 53 - 63

Published: Sept. 26, 2024

The non-saponin (NS) fraction is an important active component of Panax ginseng, with multifunctional pharmacological activities including neuroprotective, immune regulatory, anti-inflammatory, and antioxidant effects. However, the effects NSs on multiple sclerosis (MS), a chronic autoimmune demyelinating disorder, have not yet been demonstrated. Methods: goal present study was to demonstrate actions movement dysfunctions related mechanisms action using experimental encephalomyelitis (EAE) mouse model MS. (p.o.) alleviated in EAE mice reduced demyelination lumbar spinal cord (LSC). attenuated recruitment microglia (CD11b+/CD45low) macrophages (CD11b+/CD45high) LSCs from mice, consistent decreased mRNA expression levels main proinflammatory mediators (IL-1β, COX-2, MCP-1, MIP-1α, RANTES). blocked migration Th17 cells (CD4+/IL17A+) IL-17A (product cells) mice. suppressed alterations blood-brain barrier (BBB) components, such as astrocytes cell adhesion molecules, associated inhibiting NF-κB p38 MAPK pathways lipopolysaccharide-induced bEND.3 cells. could attenuate pathological/inflammatory changes by reducing BBB permeability through pathway inhibition These are first results suggesting that can be potential therapeutic agents for MS permeability.

Language: Английский

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Integrating tradition and innovation: Health industry opportunities for ginseng with foods and medicines

Chinese Herbal Medicines, Journal Year: 2024, Volume and Issue: 16(4), P. 487 - 488

Published: Oct. 1, 2024

Language: Английский

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