Cellular and molecular mechanisms of oroxylin A in cancer therapy: Recent advances DOI
Pengxin Wang,

Xiao-Nan Mu,

Shuhong Huang

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 969, P. 176452 - 176452

Published: Feb. 28, 2024

Language: Английский

Dual-responsive Tumbleweed-inspired Soft Robot Based on Poly(N‑isopropylacrylamide) and MoS2 for Targeted Drug Delivery in Stomach DOI
Xiangyu Teng, Shan Yu,

Zezheng Qiao

et al.

Journal of Bionic Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Language: Английский

Citations

0
Highly efficient tumor oxygen supplementation MnO2 nano-MOF encapsulated Sorafenib for multiple synergistic CDT/PDT/RT DOI

Shuangshuang Guo,

Miaomiao Chen, Yuhao Yang

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125328 - 125328

Published: Feb. 1, 2025

Language: Английский

Citations

0
A comprehensive review on the latest advances of dimeric anticancer prodrugs DOI

Zhila Imani,

Ebrahim Saeedian Moghadam,

Zahra Imani

et al.

Future Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: Feb. 20, 2025

The advancement of targeted drug delivery systems has opened up a wide array opportunities in cancer therapy, leading to the exploration various strategies. Among these, use prodrugs stands out as particularly promising approach treatment, aimed at enhancing selectivity and effectiveness cytotoxic agents. In last few years, there been considerable progress area dimeric-based therapy. advantages presented by have significantly improved efficiency delivering anticancer drugs, characterized high loading capacity, advantageous pharmacokinetics, release that responds tumor stimuli. With respect importance dimerization field prodrug development, herein we review latest reports covering research dimeric prodrugs. We categorized article according reported also spent great deal attention on different types used linkers methods dissociation into free monomeric drugs. Readers will easily be able compare between using same drugs with or well cell lines studies.

Language: Английский

Citations

0
Concept of Targeted Drug Conjugate and Its Application in Reversing Drug Resistance DOI
Yuanjiang Wang, Wenqing Xu, Bin Zhang

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Small-molecule targeted drugs have become the mainstream cancer treatment due to their specific therapy. However, drug resistance inevitably happens patients. Herein, we propose "targeted conjugate (TDC)" concept design that enhance antitumor activity, reduce toxicity, and reverse resistance. Upon this idea, compounds Lapa-603 Lapa-604 were obtained by modifying Pt(II) units with Lapatinib's pharmacophore. Research has found can potently inhibit proliferation of tested cells multiple cell targeting EGFR protein causing severe DNA damage. More importantly, presented higher tumor growth inhibitory efficacy than Lapatinib, Cisplatin, or physical mixtures in both MDA-MB-231 BT474 xenograft models. Our research provided promise for development novel based on TDC effectively overcome stronger activity lower toxicity corresponding combination

Language: Английский

Citations

0
Weaponizing chitosan and its derivatives in the battle against lung cancer DOI
Haitham Amin, Islam M. Ibrahim,

Emad H.M. Hassanein

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 272, P. 132888 - 132888

Published: June 1, 2024

Language: Английский

Citations

4
PepGAT, a chitinase-derived peptide, alters the proteomic profile of colorectal cancer cells and perturbs pathways involved in cancer survival DOI
Pedro F.N. Souza,

Elmer Adilson Espino Zelaya,

Emerson Lucena da Silva

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 299, P. 140204 - 140204

Published: Jan. 21, 2025

Language: Английский

Citations

0
Anti-cancer drug administration in cancer treatment under stochastic disturbances: modeling and numerical optimization algorithms DOI Creative Commons
Xiang Wu, Xiao‐Tong Yuan, Kanjian Zhang

et al.

Advances in Continuous and Discrete Models, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 17, 2025

Language: Английский

Citations

0
Autophagy induced by metabolic processes leads to solid tumor cell metastatic dormancy and recurrence DOI

Saeid Ferdousmakan,

Dorrin Mansourian,

Fatemeh Sadat Seyedi Asl

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(3)

Published: Feb. 3, 2025

Language: Английский

Citations

0
Cobalt Carbonate Nanorods Enhance Chemotherapy via Neutralization of Acidic Tumor Microenvironment and Generation of Carbonate Radical Anions for Necrosis DOI
Min Wu,

Bing Liang,

Lu Zhang

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 250, P. 114563 - 114563

Published: Feb. 12, 2025

Language: Английский

Citations

0
Bio-inspired, programmable biomacromolecules based nanostructures driven cancer therapy DOI
Rahul Sharma, Unnati Modi, Rahul Kumar

et al.

Biomaterials Advances, Journal Year: 2025, Volume and Issue: 171, P. 214235 - 214235

Published: Feb. 15, 2025

Language: Английский

Citations

0