Oxyntomodulin physiology and its therapeutic development in obesity and associated complications DOI Creative Commons
Martin Tze Wah Kueh, Ming Chuen Chong, Alexander D. Miras

et al.

The Journal of Physiology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Abstract Incretins, such as glucagon‐like peptide‐1 (GLP1) and glucose‐dependent insulinotropic polypeptide (GIP), have advanced the treatment landscape of obesity to a new pinnacle. As opposed singular incretin effects, oxyntomodulin (OXM) activates glucagon receptors (GCGR) (GLP1R), demonstrating more dynamic range effects that are likely align with evolving ‘health gains’ goals in care. Here, we will review molecular insights from their inception recent developments challenges. This discuss physiological actions OXM, primarily appetite regulation, energy expenditure, glucose homeostasis. Finally, shed light on development OXM‐based therapies for associated complications, outline important considerations translational efforts. image

Language: Английский

Relief of loperamide-induced constipation by peptidic and small molecule RXFP4 agonists in mice DOI

Shiyu Yan,

Yan Chen, Jiang Wang

et al.

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 116924 - 116924

Published: April 1, 2025

Language: Английский

Citations

0
Oxyntomodulin physiology and its therapeutic development in obesity and associated complications DOI Creative Commons
Martin Tze Wah Kueh, Ming Chuen Chong, Alexander D. Miras

et al.

The Journal of Physiology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Abstract Incretins, such as glucagon‐like peptide‐1 (GLP1) and glucose‐dependent insulinotropic polypeptide (GIP), have advanced the treatment landscape of obesity to a new pinnacle. As opposed singular incretin effects, oxyntomodulin (OXM) activates glucagon receptors (GCGR) (GLP1R), demonstrating more dynamic range effects that are likely align with evolving ‘health gains’ goals in care. Here, we will review molecular insights from their inception recent developments challenges. This discuss physiological actions OXM, primarily appetite regulation, energy expenditure, glucose homeostasis. Finally, shed light on development OXM‐based therapies for associated complications, outline important considerations translational efforts. image

Language: Английский

Citations

0