Eleutheroside B alleviates oxidative stress and neuroinflammation by inhibiting the JAK2/STAT3 signaling pathway in a rat high altitude cerebral edema model DOI Creative Commons
Yacong He, Hongying Zhang, Zhang Xiu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 15, 2024

Background High altitude cerebral edema (HACE) is a condition where the central nervous system experiences severe impairment as result of sudden oxygen deprivation at high elevations. At present, effective measures for preventing and treating this are still lacking. Eleutheroside B (EB), primary natural active compound found in senticosus , has demonstrated various biological functions. It also shown significant potential addressing acute mountain sickness neurological disorders. However, additional investigation required to explore protective effects its underlying mechanisms EB on HACE. Methods The male rats received pre-treatment with either vehicle, 100 mg/kg or 50 mg/kg, Dexamethasone 4 coumermycin A1 μg/kg. To simulate hypobaric hypoxia environment plateau 6,000 m, chamber was utilized. therapeutic were assessed through measurements brain water content, histopathological observation, evaluation oxidative stress inflammatory factors using immunofluorescence ELISA. Furthermore, molecular docking, dynamics simulation Western blot employed clarify mechanism. Through these analyses, mechanism by which HACE identified. Results Pre-treatment effect against effectively reducing down-regulating HIF-1α AQP4 protein expression induced reversing pathological changes tissue neuron damage. Compared group treated alone, pre-treated showed reduction levels ROS MDA, well an increase GSH. In addition, led decrease IL-1β, IL-6, TNF-α. Molecular docking simulations indicated that strong binding affinity JAK2/STAT3 signaling pathway. further confirmed significantly downregulated related proteins rats. Additionally, A1, agonist JAK2, reversed anti-oxidative neuroinflammation EB. Conclusion exerts antioxidant anti-neuroinflammatory inhibiting pathway rat model.

Language: Английский

Exploring the mechanism of Radix Bupleuri in the treatment of depression combined with SARS-CoV-2 infection through bioinformatics, network pharmacology, molecular docking, and molecular dynamic simulation DOI Creative Commons

Zexing Chen,

Xinhua Wang,

Wanyi Huang

et al.

Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(1)

Published: Jan. 17, 2025

Language: Английский

Citations

1
Polysaccharides with antioxidant activity: Extraction, beneficial roles, biological mechanisms, structure-function relationships, and future perspectives: A review DOI
Xiao‐fei Liu, Liufang Huang,

Xuewu Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 300, P. 140221 - 140221

Published: Jan. 22, 2025

Language: Английский

Citations

1
The transcription factor STAT3 and aging: an intermediate medium DOI

Min Shi,

H Li,

Runyu Liang

et al.

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: Feb. 7, 2025

Language: Английский

Citations

1
Limonin (LM) and its derivatives: Unveiling the neuroprotective and anti-inflammatory potential of LM and V-A-4 in the management of Alzheimer's disease and Parkinson's disease DOI
Siva Prasad Panda, Adarsh Kesharwani,

Mansi Singh

et al.

Fitoterapia, Journal Year: 2024, Volume and Issue: 178, P. 106173 - 106173

Published: Aug. 6, 2024

Language: Английский

Citations

7
Targeting the STAT3 pathway with STAT3 degraders DOI
Zhijie Wang,

Xiaotong Liao,

Haiqi He

et al.

Trends in Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 45(9), P. 811 - 823

Published: Aug. 7, 2024

Language: Английский

Citations

6
Janus Kinase 2/Signal Transducer and Activator of Transcription 3/Cyclooxygenase 2 Signaling Pathway Mediates the Effect of Central Angiotensin II on the Elevation of Rostral Ventrolateral Medulla Prostaglandin E 2 ‐Induced Oxidative Stress in Hypertension DOI Creative Commons

Jie‐Fu Fan,

Xing Tan,

Wen Wang

et al.

Journal of the American Heart Association, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Background Prostaglandin E 2 (PGE ) in the rostral ventrolateral medulla (RVLM) has been recognized as a pivotal pressor substance hypertension, yet understanding of its effects and origins RVLM remains largely elusive. This study aimed to elucidate enzymes molecular mechanisms underlying PGE synthesis induced by central Ang II (angiotensin II) implications heightened oxidative stress sympathetic outflow hypertension. Methods Results microinjections Tempol were administered Wistar‐Kyoto rats. Intracisternal drug delivery adeno‐associated viral vectors microinjection used both rats spontaneous hypertensive modulate function II, receptor 3, expression COX2 (cyclooxygenase 2). Microinjection into significantly augmented activity (25.380±1.566%) level, whereas intracisternal infusion prostaglandin 3 antagonist attenuated II‐induced Furthermore, treatment upregulated neurons (1.000±0.112 versus 1.506±0.370 fold change), with no significant effect on other involved synthesis. Additionally, inhibition JAK2/STAT3 (Janus kinase 2/signal transducer activator transcription 3) signaling pathway nullified II‐mediated elevation expression, evidenced phosphorylated STAT3 binding sequence PC12 cells. Conclusions Central induces accumulation through neuronal AT1R type 1 receptor)/JAK2/STAT3/COX2 pathway, thereby promoting stress, augmenting outflow, contributing essential

Language: Английский

Citations

0
Microglial cannabinoid receptor 2 and epigenetic regulation: implications for the treatment of depression DOI Creative Commons
Priyanka Sharma,

Rajni Daksh,

Saumya Khanna

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177422 - 177422

Published: Feb. 1, 2025

Language: Английский

Citations

0
Indole-3-Propionic Acid Attenuates Neuroinflammation and Cognitive Deficits by Inhibiting the RAGE-JAK2-STAT3 Signaling Pathway DOI

Zhizhong Hao,

Rong Ji, Yujing Su

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: 73(9), P. 5208 - 5222

Published: Feb. 24, 2025

Cognitive disorders such as Alzheimer's disease (AD) are highly prevalent and place heavy burdens on society. Neuroinflammation is a driver of cognitive impairment, with no effective drugs. Indole 3-propionic acid (IPA) tryptophan metabolite mainly produced byClostridium sporogenes, which exhibits multiple functions, including antioxidant, anti-inflammatory, antiaging, neuroprotective properties. However, the restorative effects molecular mechanisms IPA in impairment remain to be investigated. In this study, we found that reduced LPS-induced apoptosis oxidative damage HT22 cells decreased inflammation BV2 cells. Besides, promoted neurogenesis, inhibited glial cell activation, maintained integrity BBB intestinal barrier, remodeled gut microbiota, thereby alleviating memory cognitively impaired mice. At mechanistic level, RAGE-JAK2-STAT3 signaling pathway thus ameliorated neuroinflammation. Interestingly, Colivelin TFA, an activator JAK2-STAT3 signaling, partially reversed neurorestorative IPA. conclusion, ameliorates neuroinflammation deficits via inhibition pathway. Thus, may potential drug for treatment disorders.

Language: Английский

Citations

0
Dissecting Causal Relationships Between gut microbiota imbalance, inflammatory cytokines, and structural connectivity in the brain: A Mendelian Randomization Study DOI Creative Commons
Qiao‐Nan Guo, Dongli Yang, Aamir Fahira

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract Background: Growing evidence indicates that the imbalances in gut microbiota influence brain structural connectivity, a key component of microbiota-gut-brain axis. However, deeper understanding this complex bidirectional relationship remains elusive. This study aims to deepen our by examining underlying causal and mediating role inflammatory cytokines. Methods: analyzed GWAS data from 18,340 participants for composition MRI 82,382 connectivity. We conducted two-sample Mendelian randomization (MR) explore potential relationships between 211 taxa 206 connectivity features. A two-step mediation analysis involving 41 cytokines was performed, using inverse variance weighted (IVW) method as main analytical approach, supplemented sensitivity analyses reverse MR check robustness, causation, heterogeneity, horizontal pleiotropy. Results: After Bonferroni correction, identified significant correlations 11 pairs traits, with 6 positive 5 negative associations. Reverse confirmed associations nine pairs. Sensitivity found no pleiotropy, or causality. Inflammatory cytokines, such RANTES, HGF, IL-13, mediated 10–30% these relationships, mainly through JAK-STAT, IL-17, MAPK pathways. Conclusion: research establishes links bridging crucial gap axis research. These findings enhance suggest new therapeutic targets neurological disorders.

Language: Английский

Citations

0
V-set and immunoglobulin domain containing 4 as a potential predictor of Alzheimer's disease and advanced aging DOI Creative Commons

Bowen Yang,

Aygun Teymur,

Chenling Tang

et al.

Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Background V-set and immunoglobulin domain containing 4 (VSIG4) emerges as a significant player in the immune system pathways. It has been previously identified potential hub gene for Alzheimer's disease (AD) aging, underscoring its importance understanding these conditions. Objective This study aimed to evaluate diagnostic of serum VSIG4 identify trends relationship with other biomarkers neurological tests. Methods ELISA was used measure concentration AD, compared healthy subjects. The between levels age subjects, well AD-related proteins various measures cognition examined. Results significantly elevated AD patients controls (p = 0.0074). Significant correlations were notable related inflammation, such total tau, neurofilament light (NfL), YKL-40, CD14, FABP3, TNF-α. also results Conclusions Serum may reflect neuroinflammation altered lipid processing, affecting cognitive performance aging.

Language: Английский

Citations

0