Interplay of cell death pathways and immune responses in ischemic stroke: insights into novel biomarkers DOI
Arian Daneshpour, Zoha Shaka, Nima Rezaei

et al.

Reviews in the Neurosciences, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract Stroke is a severe neurological disease and major worldwide issue, mostly manifesting as ischemic stroke (IS). In order to create effective treatments for IS, it imperative fully understand the underlying pathologies, existing therapeutic choices are inadequate. Recent investigations have shown complex relationships between several programmed cell death (PCD) pathways, including necroptosis, ferroptosis, pyroptosis, their correlation with immune responses during IS. However, this relationship still unclear. To address gap, review study explored cellular interactions in microenvironment of Then, validate prior findings uncover biomarkers, investigated bioinformatics studies. Several nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB), Toll-like receptor 4 (TLR4), receptor-interacting protein kinase (RIPK), were involved PCD-immune interactions. The studies reported key biomarkers such glutathione peroxidase (GPX4), NOD-like family pyrin domain containing 3 (NLRP3), gasdermin D (GSDMD), TLR4, which important implications cuproptosis, necroptosis respectively. These associated PCD mechanisms oxidative stress inflammatory reactions. infiltration analysis consistently revealed significant pathways detrimental cells, neutrophils γδ T cells. Conversely, M2 macrophages helper showed protective effects. conclusion, considering intricate network emphasized necessity paradigm shift approaches injuries that related network.

Language: Английский

Exploring the Nexus: How Ferroptosis, Microglia, and Neuroinflammation Converge in Ischemic Stroke Pathogenesis DOI Creative Commons

Zhiyan Liu,

Xueyang Shen,

Mingming Li

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Language: Английский

Citations

0
Mechanisms Associated with Mitophagy and Ferroptosis in Cerebral Ischemia-reperfusion Injury DOI Creative Commons

Yuping Ma,

X Wang,

Yahui Li

et al.

Journal of Integrative Neuroscience, Journal Year: 2025, Volume and Issue: 24(3)

Published: March 18, 2025

Ischemic stroke (IS) constitutes a major threat to human health. Vascular recanalization by intravenous thrombolysis and mechanical remain the most significant effective methods for relief of ischemia. Key elements these treatments include achieving blood-vessel recanalization, restoring brain-tissue reperfusion, preserving ischemic penumbra. However, in therapeutic goals vascular secondary damage brain tissue from cerebral ischemia-reperfusion injury (CIRI) must also be addressed. Despite advancements understanding pathological processes associated with CIRI, interventions prevent its onset progression are still lacking. Recent research has indicated that mitophagy ferroptosis critical mechanisms development significantly contribute IS CIRI because common targets co-occurrence mechanisms. Therefore, exploring summarizing potential connections between during is crucial. In present review, we mainly focused on mitochondrial autophagy ferroptosis, their interaction, CIRI. We believe data show strong relationship interactive regulation. This information may underpin new approaches prevention treatment subsequent

Language: Английский

Citations

0
Neuroprotective mechanisms of microglia in ischemic stroke: a review focused on mitochondria DOI
Jianhua Gan, Xinyi Yang, Jianan Wu

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: April 1, 2025

Language: Английский

Citations

0
The role of microglia in neurodegenerative diseases: from the perspective of ferroptosis DOI
Yingjuan Liu, Guang Jia,

Sheng-Han Zhang

et al.

Acta Pharmacologica Sinica, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Language: Английский

Citations

0
Nuclear factor erythroid 2-related factor-mediated signaling alleviates ferroptosis during cerebral ischemia-reperfusion injury DOI Open Access
Zheng Li, Jihong Xing

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117513 - 117513

Published: Sept. 27, 2024

Language: Английский

Citations

3
Fighting ferroptosis: Protective effects of dexmedetomidine on vital organ injuries DOI

Lei Tian,

Qian Liu, Xing Wang

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 354, P. 122949 - 122949

Published: Aug. 8, 2024

Language: Английский

Citations

1
KLF6 silencing attenuates MCAO-induced brain injury and cognitive dysfunction via targeting ferroptosis and activating the Nrf2/HO-1 pathway DOI Creative Commons
Hongyu Qian, Sufang Zhou, Rong Qian

et al.

Human & Experimental Toxicology, Journal Year: 2024, Volume and Issue: 43

Published: Jan. 1, 2024

Introduction The incidence of cerebral ischemia-reperfusion injury (I/R) is complex which seriously threatens the life safety patients. Neither its prevention nor treatment has been successful so far. Proteins that bind to DNA and belong C2/H2 zinc finger family are known as Krüppel-like factors (KLFs). Among them, KLF6 plays a vital role in proliferation, metabolism, inflammation, damage responses, although function I/R remains largely unexplored. Methods In this study, we induced ischemia rats using middle artery occlusion (MCAO) model. Neural function, infarction volume, cognitive cortical pathological lesions, ferroptosis, oxidative stress were measured. Results Our findings indicated MCAO model exhibited signs ferroptosis concurrent increase levels. Inhibition resulted significant decrease escape latency during swimming tests ( p < .05), an frequency platform crossings, prolonged duration target quadrant compared control group. Additionally, silencing mitigated MCAO-induced brain reduced evidenced by altered levels Nrf2/HO-1 signaling proteins. Discussion conclusion, our results suggest may protect against pyroptosis, stress, neurological dysfunction inactivating pathway. This study offers new perspectives on molecular mechanisms related emphasizes significance targeting for future therapeutic approaches.

Language: Английский

Citations

0
Extracellular vesicles of ADSCs inhibit ischemic stroke-induced pyroptosis through Gbp3 regulation: A role for the NLRP3/GSDMD signaling pathway DOI
Jia Wang, Hao Tang, Jianan Tian

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 146, P. 113881 - 113881

Published: Dec. 24, 2024

Language: Английский

Citations

0
Interplay of cell death pathways and immune responses in ischemic stroke: insights into novel biomarkers DOI
Arian Daneshpour, Zoha Shaka, Nima Rezaei

et al.

Reviews in the Neurosciences, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract Stroke is a severe neurological disease and major worldwide issue, mostly manifesting as ischemic stroke (IS). In order to create effective treatments for IS, it imperative fully understand the underlying pathologies, existing therapeutic choices are inadequate. Recent investigations have shown complex relationships between several programmed cell death (PCD) pathways, including necroptosis, ferroptosis, pyroptosis, their correlation with immune responses during IS. However, this relationship still unclear. To address gap, review study explored cellular interactions in microenvironment of Then, validate prior findings uncover biomarkers, investigated bioinformatics studies. Several nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB), Toll-like receptor 4 (TLR4), receptor-interacting protein kinase (RIPK), were involved PCD-immune interactions. The studies reported key biomarkers such glutathione peroxidase (GPX4), NOD-like family pyrin domain containing 3 (NLRP3), gasdermin D (GSDMD), TLR4, which important implications cuproptosis, necroptosis respectively. These associated PCD mechanisms oxidative stress inflammatory reactions. infiltration analysis consistently revealed significant pathways detrimental cells, neutrophils γδ T cells. Conversely, M2 macrophages helper showed protective effects. conclusion, considering intricate network emphasized necessity paradigm shift approaches injuries that related network.

Language: Английский

Citations

0