The Hallmarks of Ageing in Microglia

Cellular and Molecular Neurobiology, Journal Year: 2025, Volume and Issue: 45(1)

Published: May 19, 2025

Abstract As ageing is linked to the development of neurodegenerative diseases (NDs), such as Alzheimer’s Disease and Parkinson’s Disease, it important disentangle independent effect age-related changes from those due disease processes. To do so, central nervous system (CNS) cells a function advanced age need better characterisation. Microglia are particular interest their proposed links with progression NDs through control CNS immune response. Therefore, understanding extent which microglial dysfunction related phyisological ageing, rather than process, critical. microglia age, they believed take on pro-inflammatory phenotype distinct dystrophic morphology. Nevertheless, while established hallmarks have been investigated across range other cell types, macrophages, detailed consideration functional that occur in aged remains elusive. Here, we describe dynamic phenotypes evaluate current state focusing recently updated twelve ageing. Understanding how these present represents step towards characterisation essential more representative models NDs. Graphical Microglial different stages life. diverse functions throughout life; however, has inconsistent

Language: Английский

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Micronuclei formation: small nuclear packages with big genomic consequences

The Nucleus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Language: Английский

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Values of epigenetic markers in Parkinson's disease as biomarkers and therapeutic targets: A narrative review

NeuroMarkers., Journal Year: 2025, Volume and Issue: unknown, P. 100037 - 100037

Published: Feb. 1, 2025

Language: Английский

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Epigenetic regulation of iron metabolism and ferroptosis in Parkinson’s disease: Identifying novel epigenetic targets

Acta Pharmacologica Sinica, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Language: Английский

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