The Dual Roles of STAT3 in Ferroptosis: Mechanism, Regulation and Therapeutic Potential DOI Creative Commons

Jinghui Xie,

Dan Luo, Pengfei Xing

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 4251 - 4266

Published: March 1, 2025

Ferroptosis, an iron-dependent programmed mechanism of cell death that is driven by lipid peroxidation, important pathogenic factor in oncological and non-oncological disorders. Dysregulation iron metabolism profoundly influences disease progression through ferroptosis modulation. Signal transducer activator transcription 3 (STAT3), a transcriptional regulator, regulates binding to promoters key molecules such as solute carrier family 7 member 11 (SLC7A11), glutathione peroxidase 4 (GPX4), ferritin heavy chain 1 (FTH1). In this review, we described the role STAT3 supporting tumors survival suppressing malignancies, bidirectionally regulating non-tumors regulate development disease. We also reported emerging therapeutic strategies target STAT3-mediated ferroptosis, including natural phytochemicals, inhibitors, nanotechnology-enabled drug delivery systems. These advancements deepen mechanistic understanding regulation, provide new theoretical bases treat ferroptosis-related diseases.

Language: Английский

Psyllium Husk Powder improves constipation by remodeling gut microbiota and improving intestinal metabolites DOI

Zhengyu Wang,

Qianwen Lv,

Liangzhong Liu

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105828 - 105828

Published: Jan. 1, 2025

Language: Английский

Citations

0
Efficacy assessment of glycyrrhetinic acid-modified liposomes loaded with doxorubicin hydrochloride and cucurbitine B for synergistic treatment of hepatocellular carcinoma DOI
Muhan Chen, Xinze Liu, Lingchao Kong

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125360 - 125360

Published: Feb. 1, 2025

Language: Английский

Citations

0
JAK/STAT signaling as a key regulator of ferroptosis: mechanisms and therapeutic potentials in cancer and diseases DOI Creative Commons

Yimeng Dai,

Chunguo Cui,

Dan Jiao

et al.

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 7, 2025

Ferroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation, playing critical role in various diseases, including cancer, neurodegeneration, and tissue damage. This study reviews the intricate relationship between ferroptosis Janus kinase/signal transducer activator transcription (JAK/STAT) signaling pathway, highlighting its regulatory functions across multiple biological processes. Dysregulation JAK/STAT pathway implicated promoting or inhibiting ferroptosis, depending on context. JAK2 promotes activating STAT proteins, modulating expression key regulators like SLC7A11 GPX4, influencing iron homeostasis through pathways such as ferritinophagy hepcidin regulation. STAT1 activation primarily enhances suppression cystine-glutamate antiporter (System Xc-), leading to glutathione depletion contributing conditions Sjogren's syndrome age-related macular degeneration. In contrast, STAT3 plays protective upregulating which inhibits survival, particularly cancers hepatocellular carcinoma, prostate renal carcinoma. also discusses STAT6's involvement diseases asthma lung injury regulating antioxidant defenses. Furthermore, review explores potential therapeutic strategies targeting manipulate for disease treatment. cancer therapy, this can enhance effectiveness inducers, offering promising avenues overcome drug resistance. Additionally, interplay immune responses, oxidative stress, metabolism underscores significance progression intervention. By exploring these mechanisms, provides insights into development novel treatments modulation, with implications inflammatory neurodegenerative conditions.

Language: Английский

Citations

0
The Dual Roles of STAT3 in Ferroptosis: Mechanism, Regulation and Therapeutic Potential DOI Creative Commons

Jinghui Xie,

Dan Luo, Pengfei Xing

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 4251 - 4266

Published: March 1, 2025

Ferroptosis, an iron-dependent programmed mechanism of cell death that is driven by lipid peroxidation, important pathogenic factor in oncological and non-oncological disorders. Dysregulation iron metabolism profoundly influences disease progression through ferroptosis modulation. Signal transducer activator transcription 3 (STAT3), a transcriptional regulator, regulates binding to promoters key molecules such as solute carrier family 7 member 11 (SLC7A11), glutathione peroxidase 4 (GPX4), ferritin heavy chain 1 (FTH1). In this review, we described the role STAT3 supporting tumors survival suppressing malignancies, bidirectionally regulating non-tumors regulate development disease. We also reported emerging therapeutic strategies target STAT3-mediated ferroptosis, including natural phytochemicals, inhibitors, nanotechnology-enabled drug delivery systems. These advancements deepen mechanistic understanding regulation, provide new theoretical bases treat ferroptosis-related diseases.

Language: Английский

Citations

0