The Power of Movement: How Exercise Influences Chemotherapy-Induced Peripheral Neuropathy DOI Creative Commons

Joana Loureiro,

José Tiago Costa‐Pereira, Daniel Humberto Pozza

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(5), P. 1103 - 1103

Published: May 1, 2025

As the number of cancer patients and survivors increases, we face a rising challenge: long-term impact adverse effects treatment. One known is chemotherapy-induced peripheral neuropathy (CIPN), which courses with pain complaints. The treatments CIPN have reduced efficacy. neurobiological causes been mainly ascribed to nerve damage, but recent studies show in brain, namely descending modulatory systems. Physical exercise seems be associated better outcomes patients, mechanisms underlying not discussed, considering results brain structures involved modulation. In this critical review, propose that beneficial also central mechanisms, neuroinflammation oxidative stress, as well changes actions neurotransmitters neurotrophic factors, direct effect on optimizing endogenous modulation, opioids, monoamines, endocannabinoids. are multifactorial, mood improvement other psychological benefits should considered. emerging role microbiome, affected during CIPN, needs This review critically synthesizes available literature highlight how physical make it promising strategy for managing both from preventive treatment perspectives.

Language: Английский

Integrative review of the gut microbiome’s role in pain management for orthopaedic conditions DOI
Naveen Jeyaraman,

Madhan Jeyaraman,

Priya Dhanpal

et al.

World Journal of Experimental Medicine, Journal Year: 2025, Volume and Issue: 15(2)

Published: April 11, 2025

The gut microbiome, a complex ecosystem of microorganisms, has significant role in modulating pain, particularly within orthopaedic conditions. Its impact on immune and neurological functions is underscored by the gut-brain axis, which influences inflammation, pain perception, systemic responses. This integrative review examines current research how dysbiosis associated with various pathways, notably nociceptive neuroinflammatory mechanisms linked to central sensitization. We highlight advancements meta-omics technologies, such as metagenomics metaproteomics, deepen our understanding microbiome-host interactions their implications pain. Recent studies emphasize that gut-derived short-chain fatty acids microbial metabolites play roles neuroinflammation nociception, contributing management. Probiotics, prebiotics, synbiotics, faecal microbiome transplants are explored potential therapeutic strategies alleviate through modulation, offering an adjunct or alternative opioids. However, variability individual microbiomes poses challenges standardizing these treatments, necessitating further rigorous clinical trials. A multidisciplinary approach combining microbiology, immunology, neurology, orthopaedics essential develop innovative, personalized management rooted health, transform care.

Language: Английский

Citations

0
The Power of Movement: How Exercise Influences Chemotherapy-Induced Peripheral Neuropathy DOI Creative Commons

Joana Loureiro,

José Tiago Costa‐Pereira, Daniel Humberto Pozza

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(5), P. 1103 - 1103

Published: May 1, 2025

As the number of cancer patients and survivors increases, we face a rising challenge: long-term impact adverse effects treatment. One known is chemotherapy-induced peripheral neuropathy (CIPN), which courses with pain complaints. The treatments CIPN have reduced efficacy. neurobiological causes been mainly ascribed to nerve damage, but recent studies show in brain, namely descending modulatory systems. Physical exercise seems be associated better outcomes patients, mechanisms underlying not discussed, considering results brain structures involved modulation. In this critical review, propose that beneficial also central mechanisms, neuroinflammation oxidative stress, as well changes actions neurotransmitters neurotrophic factors, direct effect on optimizing endogenous modulation, opioids, monoamines, endocannabinoids. are multifactorial, mood improvement other psychological benefits should considered. emerging role microbiome, affected during CIPN, needs This review critically synthesizes available literature highlight how physical make it promising strategy for managing both from preventive treatment perspectives.

Language: Английский

Citations

0