Integrative review of the gut microbiome’s role in pain management for orthopaedic conditions
Naveen Jeyaraman,
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Madhan Jeyaraman,
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Priya Dhanpal
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et al.
World Journal of Experimental Medicine,
Journal Year:
2025,
Volume and Issue:
15(2)
Published: April 11, 2025
The
gut
microbiome,
a
complex
ecosystem
of
microorganisms,
has
significant
role
in
modulating
pain,
particularly
within
orthopaedic
conditions.
Its
impact
on
immune
and
neurological
functions
is
underscored
by
the
gut-brain
axis,
which
influences
inflammation,
pain
perception,
systemic
responses.
This
integrative
review
examines
current
research
how
dysbiosis
associated
with
various
pathways,
notably
nociceptive
neuroinflammatory
mechanisms
linked
to
central
sensitization.
We
highlight
advancements
meta-omics
technologies,
such
as
metagenomics
metaproteomics,
deepen
our
understanding
microbiome-host
interactions
their
implications
pain.
Recent
studies
emphasize
that
gut-derived
short-chain
fatty
acids
microbial
metabolites
play
roles
neuroinflammation
nociception,
contributing
management.
Probiotics,
prebiotics,
synbiotics,
faecal
microbiome
transplants
are
explored
potential
therapeutic
strategies
alleviate
through
modulation,
offering
an
adjunct
or
alternative
opioids.
However,
variability
individual
microbiomes
poses
challenges
standardizing
these
treatments,
necessitating
further
rigorous
clinical
trials.
A
multidisciplinary
approach
combining
microbiology,
immunology,
neurology,
orthopaedics
essential
develop
innovative,
personalized
management
rooted
health,
transform
care.
Language: Английский
The Power of Movement: How Exercise Influences Chemotherapy-Induced Peripheral Neuropathy
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(5), P. 1103 - 1103
Published: May 1, 2025
As
the
number
of
cancer
patients
and
survivors
increases,
we
face
a
rising
challenge:
long-term
impact
adverse
effects
treatment.
One
known
is
chemotherapy-induced
peripheral
neuropathy
(CIPN),
which
courses
with
pain
complaints.
The
treatments
CIPN
have
reduced
efficacy.
neurobiological
causes
been
mainly
ascribed
to
nerve
damage,
but
recent
studies
show
in
brain,
namely
descending
modulatory
systems.
Physical
exercise
seems
be
associated
better
outcomes
patients,
mechanisms
underlying
not
discussed,
considering
results
brain
structures
involved
modulation.
In
this
critical
review,
propose
that
beneficial
also
central
mechanisms,
neuroinflammation
oxidative
stress,
as
well
changes
actions
neurotransmitters
neurotrophic
factors,
direct
effect
on
optimizing
endogenous
modulation,
opioids,
monoamines,
endocannabinoids.
are
multifactorial,
mood
improvement
other
psychological
benefits
should
considered.
emerging
role
microbiome,
affected
during
CIPN,
needs
This
review
critically
synthesizes
available
literature
highlight
how
physical
make
it
promising
strategy
for
managing
both
from
preventive
treatment
perspectives.
Language: Английский