Cardiovascular and nonalcoholic fatty liver disease: Sharing common ground through SIRT1 pathways DOI Open Access
Kenneth Maiese

World Journal of Cardiology, Journal Year: 2024, Volume and Issue: 16(11), P. 632 - 643

Published: Oct. 30, 2024

As a non-communicable disease, cardiovascular disorders have become the leading cause of death for men and women. Of additional concern is that disease linked to chronic comorbidity include nonalcoholic fatty liver (NAFLD). NAFLD, also termed metabolic-dysfunction-associated steatotic greatest throughout world, increasing in prevalence concurrently with diabetes mellitus (DM), can progress steatohepatitis leads cirrhosis fibrosis. Individuals metabolic disorders, such as DM, are more than two times likely experience cardiac stroke, includes NAFLD when compared individuals without disorders. Interestingly, share common underlying cellular mechanism pathology, namely silent mating type information regulation 2 homolog 1 (SIRT1;

Language: Английский

Angel or devil: the dual roles of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucopyranoside in the development of liver injury based on integrating pharmacological techniques: a systematic review DOI Creative Commons
Jiajie Jiang,

Qin Wang,

Qiang Wu

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 3, 2025

Background and purpose 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) exhibits a dualistic pharmacological profile, acting as both hepatoprotective hepatotoxic agent, which is intricately linked to its interaction with multiple signaling pathways stereoisomeric forms, namely, cis-SG trans-SG. The of this study evaluate the effects TSG give therapeutic guidance. Methods This performed systematic search eight databases identify preclinical literature up until March 2024. CAMARADES system evaluated evidence quality bias. STATA Python were used for statistical analysis, including dose-effect maps, 3D maps radar charts show dose-time-effect relationship on hepatoprotection hepatotoxicity. Results After rigorous screening process, total 24 studies encompassing 564 rodents selected inclusion in study. findings revealed that exhibited bidirectional levels ALT AST, while also regulating ALT, TNF-α, IL-6, serum TG, TC, SOD, MDA, IFN-γ, apoptosis rate. histological analysis liver tissue confirmed regulatory TSG, comprehensive optimal protective dosage range was 27.27–38.81 mg/kg/d toxic 51.93–76.07 mg/kg/d. exerts dual injury (LI) through network Keap1/Nrf2/HO-1/NQO1, NF-κB, PPAR, PI3K/Akt, JAK/STAT TGF-β pathways. Conclusion could mediate oxidation, inflammation, metabolism result (27.27–38.81 mg/kg/d) hepatotoxicity (51.93–76.07 mg/kg/d).

Language: Английский

Citations

0
Vortioxetine alleviates motor, cognitive and emotional disorders in post-stroke rats by regulating the TLR-2/NF-κB pathway DOI Creative Commons

Ziqiang Dong,

Zhihui Dong, Lili Xu

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 12, 2025

Cognitive impairments following post-stroke significantly hinder neurological recovery and exacerbate patient morbidity, underscoring urgent need for effective therapeutic strategies. Vortioxetine (VTX), a prominent Selective Serotonin Reuptake Inhibitor (SSRI), boasts notable antidepressant, cognition-enhancing, anti-inflammatory properties. This investigation delves into VTX’s influence on motor skills, spatial learning-memory capabilities, depressive behaviors in Middle Cerebral Artery Occlusion (MCAO) rats, alongside its underlying mechanisms. Our findings reveal that while VTX fails to entirely reverse ischemic-reperfusion damage, it substantially ameliorates spontaneous locomotor functions, augments capacities, exhibits potent antidepressant anxiety-like efficacy. Preliminary data propose these beneficial effects may stem from inflammation modulation via the Toll-Like Receptor 2 (TLR-2)/Nuclear Factor-Kappa B (NF- κ B) signaling pathway. Collectively, our work underscores promising role enhancing motor, cognitive mitigating symptoms cerebrovascular accidents, potentially through regulation. These insights pave way novel interventions addressing complications, warranting further exploration.

Language: Английский

Citations

0
Tripterygium glycoside tablets and triptolide alleviate experimental autoimmune encephalomyelitis mice involving the PACAP/cAMP signaling pathway DOI
Hong Wang, Juan Zou, Yiming Li

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119748 - 119748

Published: April 1, 2025

Language: Английский

Citations

0
Cardiovascular and nonalcoholic fatty liver disease: Sharing common ground through SIRT1 pathways DOI Open Access
Kenneth Maiese

World Journal of Cardiology, Journal Year: 2024, Volume and Issue: 16(11), P. 632 - 643

Published: Oct. 30, 2024

As a non-communicable disease, cardiovascular disorders have become the leading cause of death for men and women. Of additional concern is that disease linked to chronic comorbidity include nonalcoholic fatty liver (NAFLD). NAFLD, also termed metabolic-dysfunction-associated steatotic greatest throughout world, increasing in prevalence concurrently with diabetes mellitus (DM), can progress steatohepatitis leads cirrhosis fibrosis. Individuals metabolic disorders, such as DM, are more than two times likely experience cardiac stroke, includes NAFLD when compared individuals without disorders. Interestingly, share common underlying cellular mechanism pathology, namely silent mating type information regulation 2 homolog 1 (SIRT1;

Language: Английский

Citations

0