Ferroptosis: mechanism and role in diabetes-related cardiovascular diseases

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 7, 2025

Cardiovascular diseases represent the principal cause of death and comorbidity among people with diabetes. Ferroptosis, an iron-dependent non-apoptotic regulated cellular characterized by lipid peroxidation, is involved in pathogenesis diabetic cardiovascular diseases. The susceptibility to ferroptosis hearts possibly related myocardial iron accumulation, abnormal metabolism excess oxidative stress under hyperglycemia conditions. Accumulating evidence suggests can be therapeutic target for This review summarizes ferroptosis-related mechanisms novel choices targeting pathways. Further study on ferroptosis-mediated cardiac injury enhance our understanding pathophysiology provide more potential choices.

Language: Английский

Targeting Ferroptosis in Parkinson’s: Repurposing Diabetes Drugs as a Promising Treatment

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1516 - 1516

Published: Feb. 11, 2025

This review explores the promising potential of repurposing type 2 diabetes (T2D) medications for treatment Parkinson's disease (PD), highlighting shared pathophysiological mechanisms between these two age-related conditions, such as oxidative stress, mitochondrial dysfunction, and ferroptosis. The overlap suggests that existing drugs could target common pathways involved in both conditions. Specifically, discusses how T2D medications, including metformin (Met), peroxisome-proliferator-activated receptor gamma (PPAR-γ) agonists, sodium-glucose cotransporter-2 (SGLT2) inhibitors, incretins, dipeptidyl-peptidase 4 (DPP-4) can improve function, reduce neuroinflammation potentially inhibit connection ferroptosis treatments, medication, are only beginning to be explored. limited data attributed also complexity fact specific role pathogenesis has not been a primary focus until recent. Despite preclinical evidence, clinical findings mixed, underscoring need further research elucidate drugs' roles neurodegeneration. Repurposing have well-established safety profiles significantly time cost associated with drug development offer more comprehensive approach managing compared treatments targeting single mechanism.

Language: Английский

Dapagliflozin activates the RAP1B/NRF2/GPX4 signaling and promotes mitochondrial biogenesis to alleviate vascular endothelial ferroptosis

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111824 - 111824

Published: April 1, 2025

Language: Английский