Temporal Dynamic Changes in Functional Connectivity of Reward Network in Depressed Adolescents and Young Adults with and without Suicidal Attempts DOI Creative Commons

Jun Cao,

Xiaorong Chen, Jianmei Chen

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract The prevalence of depression has sharply increased among adolescents and young adults over the past decade. Depression in adolescence adulthood raised growing concern because it is associated with an risk suicide, thus heightening likelihood future suicidal behavior completed suicide. However, neurobiological underpinnings depressed remain poorly understood. In this study, we investigated dynamic functional connectivity (dFC) between brain regions reward network identified alterations dynamics patterns within depression, both without a history suicide attempts, using dFC analysis. Our findings revealed significant differences several key regions, including left ventral striatum putamen, anterior insula medial superior frontal gyrus, right central as well auxiliary motor area inferior sMDDgroup, nMDD group HC group. These results demonstrate that temporal changes network, rather than resting-state (RSFC), were more strongly suicidality, suggesting such may serve important biomarker for adolescent suicidality.

Language: Английский

Temporal Dynamic Changes in Functional Connectivity of Reward Network in Depressed Adolescents and Young Adults with and without Suicidal Attempts DOI Creative Commons

Jun Cao,

Xiaorong Chen, Jianmei Chen

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract The prevalence of depression has sharply increased among adolescents and young adults over the past decade. Depression in adolescence adulthood raised growing concern because it is associated with an risk suicide, thus heightening likelihood future suicidal behavior completed suicide. However, neurobiological underpinnings depressed remain poorly understood. In this study, we investigated dynamic functional connectivity (dFC) between brain regions reward network identified alterations dynamics patterns within depression, both without a history suicide attempts, using dFC analysis. Our findings revealed significant differences several key regions, including left ventral striatum putamen, anterior insula medial superior frontal gyrus, right central as well auxiliary motor area inferior sMDDgroup, nMDD group HC group. These results demonstrate that temporal changes network, rather than resting-state (RSFC), were more strongly suicidality, suggesting such may serve important biomarker for adolescent suicidality.

Language: Английский

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