Lysosomes and LAMPs as Autophagy Drivers of Drug Resistance in Colorectal Cancer DOI Creative Commons
Tsvetomira Ivanova, Yordan Sbirkov,

Maria Kazakova

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(8), P. 574 - 574

Published: April 11, 2025

Colorectal cancer (CRC) is among the most malignant pathologies worldwide. A major factor contributing to poor prognosis of neoplastic diseases development drug resistance. It significantly reduces utility therapeutic protocols and necessitates search for novel biomarkers treatment strategies combat cancer. An evolutionarily conserved catabolic mechanism, autophagy maintains nutrient recycling metabolic adaptation also closely related carcinogenesis, playing a dual role. Autophagy inhibition can limit growth tumors improve response therapeutics. Lysosomes, key players in autophagy, are considered promising targets anticancer treatment. There still insufficient data on role poorly studied glycoproteins such as lysosome-associated membrane (LAMPs). They act multifunctional molecules involved multitude processes like development. In current review, we summarize recent double-faceted with focus resistance CRC roles lysosomes LAMPs these interconnected processes. Several lysosomotropic drugs discussed options overcome cell chemoresistance. The complex networks that underline defined autophagic pathways context carcinogenesis especially drivers resistance, outlined.

Language: Английский

Lysosomes and LAMPs as Autophagy Drivers of Drug Resistance in Colorectal Cancer DOI Creative Commons
Tsvetomira Ivanova, Yordan Sbirkov,

Maria Kazakova

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(8), P. 574 - 574

Published: April 11, 2025

Colorectal cancer (CRC) is among the most malignant pathologies worldwide. A major factor contributing to poor prognosis of neoplastic diseases development drug resistance. It significantly reduces utility therapeutic protocols and necessitates search for novel biomarkers treatment strategies combat cancer. An evolutionarily conserved catabolic mechanism, autophagy maintains nutrient recycling metabolic adaptation also closely related carcinogenesis, playing a dual role. Autophagy inhibition can limit growth tumors improve response therapeutics. Lysosomes, key players in autophagy, are considered promising targets anticancer treatment. There still insufficient data on role poorly studied glycoproteins such as lysosome-associated membrane (LAMPs). They act multifunctional molecules involved multitude processes like development. In current review, we summarize recent double-faceted with focus resistance CRC roles lysosomes LAMPs these interconnected processes. Several lysosomotropic drugs discussed options overcome cell chemoresistance. The complex networks that underline defined autophagic pathways context carcinogenesis especially drivers resistance, outlined.

Language: Английский

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