Cancer chemoprevention: signaling pathways and strategic approaches DOI Creative Commons
Junling Ren,

Guangli Yan,

Le Yang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: April 17, 2025

Abstract Although cancer chemopreventive agents have been confirmed to effectively protect high-risk populations from invasion or recurrence, only over ten drugs approved by the U.S. Food and Drug Administration. Therefore, screening potent is crucial reduce constantly increasing incidence mortality rate of cancer. Considering lengthy prevention process, an ideal agent should be nontoxic, inexpensive, oral. Natural compounds become a natural treasure reservoir for chemoprevention because their superior ease availability, cost-effectiveness, safety. The benefits as in various studies. In light this, present review intended fully delineate entire scope chemoprevention, primarily focuses on aspects based compounds, specifically focusing mechanism action prevention, discussing detail how they exert effects affecting classical signaling pathways, immune checkpoints, gut microbiome. We also introduce novel strategies summarize role improving chemotherapy regimens. Furthermore, we describe discovering anticancer with low abundance high activity, revealing broad prospects drug discovery chemoprevention. Moreover, associate precision medicine, discuss challenges encountered Finally, emphasize transformative potential advancing field ability more effective less toxic preventive options oncology.

Language: Английский

Liposome-Based Drug Delivery Systems in Cancer Research: An Analysis of Global Landscape Efforts and Achievements DOI Creative Commons
Islam Hamad, Amani A. Harb, Yasser Bustanji

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(3), P. 400 - 400

Published: March 14, 2024

Lipid-bilayer-based liposomes are gaining attention in scientific research for their versatile role drug delivery. With amphiphilic design, efficiently encapsulate and deliver drugs to targeted sites, offering controlled release. These artificial structures hold great promise advancing cancer therapy methodologies. Bibliometric analyzes systematic literary data statistically. This study used bibliometric indicators examine, map, evaluate the applications of therapy. A Scopus search was conducted identify all English-language peer-reviewed publications on within past twenty years. were calculated using VOSviewer Biblioshiny. We produced thematic, conceptual, visualization charts. total 14,873 published documents obtained. The procedure keyword mapping has effectively identified main areas concentration prevailing trends this specific field study. significant clusters discovered through theme hotspot analyses encompassed many topics such as use multiple strategies chemotherapy different forms cancer, pharmacokinetics nanomedicine, well investigation delivery, cytotoxicity, gene Liposomes employed delivery systems so selectively target cells improve bioavailability anticancer drugs. work showcased capacity tailor these accurate by including potent medications. Our findings not only bring latest progress utilizing treatment but also underscore vital need ongoing research, collaborative efforts, effective translation breakthroughs into tangible clinical applications, emphasizing dynamic evolving nature therapeutics.

Language: Английский

Citations

17
Natural compounds-based nanomedicines for cancer treatment: Future directions and challenges DOI Creative Commons
Tatiana Andreani, Ruoyu Cheng, Khalil Elbadri

et al.

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 14(10), P. 2845 - 2916

Published: July 13, 2024

Abstract Several efforts have been extensively accomplished for the amelioration of cancer treatments using different types new drugs and less invasives therapies in comparison with traditional therapeutic modalities, which are widely associated numerous drawbacks, such as drug resistance, non-selectivity high costs, restraining their clinical response. The application natural compounds prevention treatment cells has attracted significant attention from pharmaceuticals scientific communities over past decades. Although use nanotechnology therapy is still preliminary stages, nanotherapeutics demonstrated to decrease various limitations related compounds, physical/chemical instability, poor aqueous solubility, low bioavailability. Despite emerged a promise improve bioavailability there limited trials performed challenges required pre-clinical trials, production at an industrial level, assurance long-term stability, physiological barriers safety regulatory issues. This review highlights most recent advances nanocarriers secreted plants, bacteria, fungi, marine organisms, well role on cell signaling pathways anticancer treatments. Additionally, status main regarding loaded applications were also discussed. Graphical abstract

Language: Английский

Citations

17
Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies DOI Creative Commons

Neelakanta Sarvashiva Kiran,

Chandrashekar Yashaswini,

Rahul Maheshwari

et al.

ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(4), P. 967 - 990

Published: March 19, 2024

Precision medicine is transforming colorectal cancer treatment through the integration of advanced technologies and biomarkers, enhancing personalized effective disease management. Identification key driver mutations molecular profiling have deepened our comprehension genetic alterations in cancer, facilitating targeted therapy immunotherapy selection. Biomarkers such as microsatellite instability (MSI) DNA mismatch repair deficiency (dMMR) guide decisions, opening avenues for immunotherapy. Emerging liquid biopsies, artificial intelligence, machine learning promise to revolutionize early detection, monitoring, selection precision medicine. Despite these advancements, ethical regulatory challenges, including equitable access data privacy, emphasize importance responsible implementation. The dynamic nature with its tumor heterogeneity clonal evolution, underscores necessity adaptive strategies. future lies potential enhance patient care, clinical outcomes, understanding this intricate disease, marked by ongoing evolution field. current reviews focus on providing in-depth knowledge various diverse approaches utilized against at both biochemical levels.

Language: Английский

Citations

15
Rational design of a nonclassical liposomal nanoscale drug delivery system for innovative cancer therapy DOI Creative Commons
Chunjie Wang, Xiaoqi Sun, Liangzhu Feng

et al.

BMEMat, Journal Year: 2024, Volume and Issue: 2(3)

Published: April 15, 2024

Abstract Advanced drug delivery systems are widely considered to be powerful approaches for treating cancer and many other diseases because of their superior ability improve pharmacokinetics, promote lesion‐targeted efficacy, and/or reduce the toxic effects diverse therapeutics. Owing unique biomimetic structure lipid bilayers surrounding aqueous cavities, liposomes have been found encapsulate various therapeutics, ranging from small molecules with different hydrophobicities biomacromolecules. With advent surface PEGylation, stealth excellent in vivo long‐circulating behaviors generated, thus these extensively explored development liposomal drugs greatly improved pharmacokinetic by functioning as vehicles. Inspired successes clinical practice, recently utilized main building scaffold or coating layers nanoparticulate formulations, which coined nonclassical nanoscale (NDDSs) this review, enable rational design next‐generation nanomedicine. Therefore, after overviewing latest progress conventional liposome‐based nanomedicine, we will introduce NDDSs well innovative treatment strategies. We subsequently provide a critical perspective on future new nanomedicines based rationally designed NDDSs.

Language: Английский

Citations

13
Model-informed precision dosing: State of the art and future perspectives DOI Creative Commons
Iris K. Minichmayr, Erwin Dreesen, Marco Centanni

et al.

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 215, P. 115421 - 115421

Published: Aug. 17, 2024

Model-informed precision dosing (MIPD) stands as a significant development in personalized medicine to tailor drug individual patient characteristics. MIPD moves beyond traditional therapeutic monitoring (TDM) by integrating mathematical predictions of dosing, and considering patient-specific factors (patient characteristics, measurements) well different sources variability. For this purpose, rigorous model qualification is required for the application patients. This review delves into new methods selection validation, also highlighting role machine learning improving MIPD, utilization biosensors real-time monitoring, potential models biomarkers efficacy or toxicity dosing. The clinical evidence TDM discussed various medical fields including infection medicine, oncology, transplant inflammatory bowel diseases, thereby underscoring pharmacokinetics/pharmacodynamics specific biomarkers. Further research, particularly randomized trials, warranted corroborate value enhancing outcomes advancing medicine.

Language: Английский

Citations

11
Harnessing nanotechnology for cancer treatment DOI Creative Commons
Jiajun Zhu,

H. H. Lee,

Rong Huang

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 20, 2025

Nanotechnology has become a groundbreaking innovation force in cancer therapy, offering innovative solutions to the limitations of conventional treatments such as chemotherapy and radiation. By manipulating materials at nanoscale, researchers have developed nanocarriers capable targeted drug delivery, improving therapeutic efficacy while reducing systemic toxicity. Nanoparticles like liposomes, dendrimers, polymeric nanomaterials shown significant promise delivering chemotherapeutic agents directly tumor sites, enhancing bioavailability minimizing damage healthy tissues. In addition with utilization tools quantum dots nanosensors that enables more precise identification biomarkers, nanotechnology is also playing pivotal role early detection diagnosis. Furthermore, nanotechnology-based strategies, including photothermal gene therapy immunotherapy are novel ways combat by selectively targeting cells immune response. Nevertheless, despite these progressions, obstacles still persist, particularly clinical translation technologies. Issues nanoparticle toxicity, biocompatibility, complexity regulatory approval hinder widespread adoption nanomedicine oncology. This review discusses different applications highlighting its potential hurdles implementation. Future research needs concentrate on addressing unlock full providing personalized, effective, minimally invasive treatments.

Language: Английский

Citations

1
Advancements in Liposomal Nanomedicines: Innovative Formulations, Therapeutic Applications, and Future Directions in Precision Medicine DOI Creative Commons
Zahra Izadiyan, Misni Misran, Katayoon Kalantari

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 1213 - 1262

Published: Jan. 1, 2025

Liposomal nanomedicines have emerged as a pivotal approach for the treatment of various diseases, notably cancer and infectious diseases. This manuscript provides an in-depth review recent advancements in liposomal formulations, highlighting their composition, targeted delivery strategies, mechanisms action. We explore evolution products currently clinical trials, emphasizing potential addressing diverse medical challenges. The integration immunotherapeutic agents within liposomes marks paradigm shift, enabling design 'immuno-modulatory hubs' capable orchestrating precise immune responses while facilitating theranostic applications. COVID-19 pandemic has accelerated research liposomal-based vaccines antiviral therapies, underscoring need improved to overcome challenges like rapid clearance organ toxicity. Furthermore, we discuss "smart" liposomes, which can respond specific disease microenvironments, enhancing efficacy precision. artificial intelligence machine learning optimizing designs promises revolutionize personalized medicine, paving way innovative strategies detection therapeutic interventions. comprehensive underscores significance ongoing technologies, with implications future applications enhanced patient outcomes.

Language: Английский

Citations

1
Nano-targeted delivery system: a promising strategy of anthocyanin encapsulation for treating intestinal inflammation DOI

Hao Zhong,

Xin Luo,

Abdullah

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: Feb. 7, 2025

Anthocyanins are natural flavonoids derived from plants, widely recognized for their health-promoting effects, specifically to treat inflammatory bowel disease (Crohn's and ulcerative colitis). However, certain limitations associated with use, including instability, low solubility permeability, poor gastrointestinal digestion, bioavailability. In this review, nano-carriers (e.g., liposome, polymersome, exosome, halloysite nanotubes, dendrimer, nano-niosome, etc.) were summarized as anthocyanins delivery vehicles disease. Recent progress on emerging strategies involved surface functionalization, responsive release, magnetic orientation, self-assembly aggregation address intestinal inflammation through potential mechanisms discussed. Anthocyanins, water-soluble pigments linked by glycoside bonds have attracted attention alleviate related diseases. can exerting health beneficial effects such anti-oxidative, anti-inflammatory, regulating the flora, promoting apoptosis. Moreover, discussed oral system maximized bioefficacy of concerns metabolism, bioavailability A future perspective is proposed concerning anthocyanin-loaded nano-carriers, different improve efficacy, developing functional food inflammation.

Language: Английский

Citations

1
Recent Advances in Liposomes Efficacy as a Drug Delivery Platform for Melanoma Treatment DOI
Elham Zarenezhad,

Zahra Kazeminejad,

Mahsa Rostami Chijan

et al.

Russian Journal of Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 51(1), P. 93 - 116

Published: Feb. 1, 2025

Language: Английский

Citations

1
Extracellular vesicles for breast cancer diagnosis and therapy DOI Creative Commons

Jianan Shi,

Huan Zhang, Yaxin Cui

et al.

Extracellular Vesicle, Journal Year: 2024, Volume and Issue: 3, P. 100039 - 100039

Published: April 25, 2024

Breast cancer is still suffering from its poor diagnosis and the lack of effective treatment. Despite recent development some novel chemicals, which are found to have inspiring therapeutic effects in vitro, their outcomes clinic trails disappointing, mainly due suitable vehicles. Thanks ability encapsulate bio-molecules, extracellular vesicles (EVs), including exosomes, microvesicles, apoptotic bodies, hold great promise becoming a candidate breast therapy. Currently, EVs increasingly evaluated as potential indicators since they actively involved different stages development, promoting occurrence metastasis, establishing tumor ecology, growth. Moreover, also considered promising new platforms Here, we discuss applications EVs, biomarkers for drug delivery sites. The data technologies indicate applicability clinical management patients with cancer.

Language: Английский

Citations

7