Case Studies in Thermal Engineering,
Journal Year:
2024,
Volume and Issue:
57, P. 104326 - 104326
Published: March 31, 2024
This
paper
investigates
the
solubility
behavior
of
digitoxin
in
supercritical
carbon
dioxide
(CO2)
through
a
comprehensive
analysis
employing
ensemble
learning
techniques
and
various
regression
models.
The
dataset
consists
temperature
pressure
as
input
variables,
with
solvent
density
output
variables.
Utilizing
bagging
method,
Gaussian
process
(GPR),
Bayesian
Ridge
Regression
(BRR),
Orthogonal
Matching
Pursuit
(OMP),
Polynomial
(PR)
were
employed
Hyper-parameter
tuning
was
achieved
gradient-based
optimization.
Results
revealed
that
emerges
most
effective
model
for
predicting
both
solubility.
For
prediction,
BAG-PR
yields
an
R2
score
0.98527,
MSE
MAE
1.4290E-03
3.40547E-02,
respectively.
Concerning
density,
achieves
outstanding
0.99766,
along
7.4759E+01
7.33964E+00,
These
results
show
learning,
polynomial
can
accurately
predict
revealing
digitoxin's
CO2.
Case Studies in Thermal Engineering,
Journal Year:
2024,
Volume and Issue:
61, P. 105074 - 105074
Published: Sept. 1, 2024
The
complete
investigation
of
the
solubility
Ceftriaxone
sodium
drug
has
not
yet
been
conducted.
This
communication
investigates
in
supercritical
CO2
(SC-CO2)
for
first
time.
measurements
were
performed
using
utilizing
UV-vis
analysis
under
different
operation
conditions
(at
P
(bar)
=
120-270
and
T
(K)
308-338).
results
demonstrated
that
ranged
from
0.90
×
10-6
to
8.01
10-6.
mole
fraction
increases
proportionally
with
an
increase
pressure,
while
maintaining
a
constant
temperature.
However,
crossover
was
noted.
behavior
SC-CO2
modeled
by
Peng-Robinson
equation
state
(PR
EoS)
Kwak-Mansoori
van
der
Waals
mixing
rules
seven
semi-empirical
correlations
(Bian
et
al.,
Kumar-Johnston,
Chrastil,
Garlapati-Madras,
Bartle
Sung-Shim
Sodeifian
al.,).
vaporization,
total
solvation
enthalpies
sodium/SC-carbon
dioxide
system
obtained
KJ,
al.
correlations.
evaluation
two
methods
absolute
average
relative
deviation
(AARD%).
Both
models
exhibited
satisfactory
level
agreement
experimental
data.
Finally,
PR/KM
EoS
Chrastil
models,
AARD%
values
8.70%
8.10%
respectively,
showed
superior
precision
accurately
fitting
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: March 4, 2025
All
substances
exhibit
complex
behavior
near
their
critical
points,
where
even
slight
variations
in
temperature
and
pressure
can
lead
to
significant
changes
density,
heat
capacity,
compressibility.
This
rapid
variation
results
a
loss
of
surface
energy
maximizes
the
compressibility
capacity
fluids
at
point.
study
employed
molecular
dynamics
(MD)
simulations
based
on
binary
mixture
concept
predict
properties
ionic
liquids
(ILs)
that
are
difficult
measure
experimentally.
Initially,
validate
this
method,
we
investigated
density
pure
water,
ethanol,
across
different
temperatures
pressures,
specifically
phase
transition,
critical,
supercritical
points.
Then,
these
were
studied
for
[C4mim][BF4]
IL
its
The
water-ethanol
compared
with
experimental
data.
simulation
revealed
points
resembles
three
middle
point
represents
mixture's
predicted
1400
±
10
K
11
0.5
bar,
respectively.
Toxicology Research,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Dec. 31, 2024
Abstract
Methotrexate
(MTX)
is
an
antimetabolite
drug
utilized
for
managing
a
variety
of
cancers
and
autoinflammatory
conditions.
MTX
may
trigger
detrimental
effects
in
mout,
h
tissues,
including
salivary
gland
impairment.
Bosentan
(BOS),
that
blocks
endothelin
receptors,
has
strengthened
antioxidant,
anti-inflammatory,
anti-apoptotic
properties.
The
study
aimed
to
estimate
the
protective
effect
BOS
on
MTX-exacerbated
changes
Wistar
Albino
rats.
Thirty
male
rats
were
arbitrarily
sorted
into
three
groups
ten
animals
each.
control
group
received
normal
saline
18
days.
(induction)
(25
mg/kg)
intraperitoneally
7th
day
experiment
once
daily
6
consecutive
+
(50
orally
days:
days
before
induction,
2-h
after
post-induction.
Animals
euthanized
19,
tissues
dissected
biochemical,
histopathological,
immunohistochemical
analyses.
dramatically
improved
MTX-aggravated
biochemical
histopathological
abnormalities,
as
evidenced
by
diminished
Bax,
caspase
3,
TNF-α,
IL-1β,
MDA,
MPO
levels,
increased
SOD,
GSH,
GPX
reduced
degenerative
granular
convolute
tubule,
mucous
acini,
striate
duct.
further
substantially
upregulated
MTX-induced
decline
Ki-67
Bcl-2,
indicated
immunohistochemistry
scoring
methods.
anti-oxidative,
ant-inflammatory,
antiapoptotic
properties
are
promising
strategy
ameliorating
toxic
submandibular
glandular
tissues.
