Perivascular Adipose Tissue Density and Stenosis Plaque Degree in Lower Limb Peripheral Arteries in CT DOI Creative Commons

Alice Fortunati,

Chiara Perazzo,

M Basile

et al.

Journal of Vascular Diseases, Journal Year: 2024, Volume and Issue: 3(2), P. 224 - 234

Published: June 11, 2024

Background: Perivascular adipose tissue (PVAT) attenuation has emerged as a novel biomarker for identifying high-risk arterial plaques due to its association with inflammation. Recognizing the systemic nature of atherosclerosis and link major cardiovascular events in coronary disease, this study evaluated PVAT peripheral arteries using CT imaging expand understanding diagnostic prognostic potential. Methods: retrospective analysis 53 consecutive patients who underwent angiography, examining density across five primary segments. A 5 mm region interest adjacent vascular wall was analyzed by two blinded readers, reproducibility coefficients calculated determine reliability measurements. For statistical analyses, mean values were derived from these The stratified into four groups based on degree stenosis: <25%, 25–50%, 50–70%, >70%. comparisons between performed Kruskal–Wallis test pairwise Mann–Whitney U Holm–Bonferroni correction multiple comparisons. Results: revealed statistically significant disparities categorically differentiated stenosis (p < 0.001), indicating an severity. This especially pronounced external iliac, common femoral, superficial popliteal arteries, where p-values consistently below 0.05. Subsequent analyses utilizing affirmed findings, particular femoral 0.05). Conclusions: our findings reinforce correlation increased stenosis, supporting clinical value non-invasive risk stratification potentially guiding therapeutic interventions.

Language: Английский

Cardiac Computed Tomography Evaluation of Association of Left Ventricle Disfunction and Epicardial Adipose Tissue Density in Patients with Low to Intermediate Cardiovascular Risk DOI Creative Commons
Marcello Chiocchi, Armando Ugo Cavallo, Luca Pugliese

et al.

Medicina, Journal Year: 2023, Volume and Issue: 59(2), P. 232 - 232

Published: Jan. 26, 2023

Background and objectives: Epicardial adipose tissue density (EAD) has been associated with coronary arteries calcium score, a higher load of artery disease (CAD) plaque vulnerability. This effect can be related to endocrine paracrine molecules produced by epicardial (EAT), that may influence myocardial contractility. Using computed tomography angiography (CCT) the evaluation EAD is possible in basal scans. The aim study investigate associations between cardiac function. Material Methods: 93 consecutive patients undergoing CCT without contrast medium for known or suspected CAD were evaluated. was measured on scans, at level ostia, lateral free wall left ventricle, apex, origin posterior interventricular artery. Cardiac function evaluated post-contrast CT scans order calculate ejection fraction (EF), end-diastolic volume (EDV), end-systolic (ESV), stroke (SV). Results: A statistically significant positive correlation (r = 0.29, p-value < 0.01) found. Additionally, negative ESV -0.25, present. Conclusion: could considered new risk factor reduced this parameter low intermediate cardiovascular possible.

Language: Английский

Citations

3
Computed tomography measured epicardial adipose tissue and psoas muscle attenuation: new biomarkers to predict major adverse cardiac events (MACE) and mortality in patients with heart disease and critically ill patients. Part I: Epicardial adipose tissue DOI Creative Commons
Jeroen Walpot, Koen Van Herck, Caroline M. Van De Heyning

et al.

Anaesthesiology Intensive Therapy, Journal Year: 2023, Volume and Issue: 55(3), P. 141 - 157

Published: Jan. 1, 2023

Over the last two decades, potential role of epicardial adipocyte tissue (EAT) as a marker for major adverse cardiovascular events has been extensively studied. Unlike other visceral tissues (VAT), EAT is not separated from adjacent myocardium by fascial layer and shares same microcirculation with myocardium. Adipocytokines, secreted EAT, interact directly through paracrine vasocrine pathways. The Randle cycle, linking VAT accumulation to insulin resistance, relevance blood flow mitochondrial function VAT, are briefly discussed. three available imaging modalities assessment advantages echocardiography, cardiac CT, magnetic resonance (CMR) compared. section summarises current stage knowledge on clinical (MACE). association between volume coronary artery disease (CAD) robustly validated. There growing evidence that associated computed tomography angiography (CTCA) assessed high-risk plaque features. CT attenuation coefficient predicts events. Many studies have established predictor atrial fibrillation after surgery. Moreover, thickness independently severe aortic stenosis mitral annular calcification. Studies demonstrated heart failure. Finally, we discuss in critically ill patients admitted intensive care unit. In conclusion, seems be promising new biomarker predict MACE.

Language: Английский

Citations

3
PHYSIOLOGICAL AND PATHOLOGICAL SIGNIFICANCE OF PERICARDIAL FAT FOR THE HEART AND ADJACENT VESSELS DOI Creative Commons

A. Chiornaya,

I. G. Kamyshanskaya,

Ivan Pchelin

et al.

Juvenis scientia, Journal Year: 2022, Volume and Issue: 8(1), P. 32 - 41

Published: Jan. 1, 2022

Investigating the adipose tissue surrounding heart and large vessels, so-called pericardial fat, is of great interest for researchers. Pericardial fat currently being considered a new cardiovascular risk factor, which forces us to reconsider pathogenesis various disorders. The article describes concept including its heterogeneous structure origin determining functional role. In addition, specific characteristics in patients from clinical groups are described. main attention paid significance metabolic activity effect on nearby structures, such as coronary arteries. Based modern scientific concepts, we have identified components atherosclerosis, myocardial fibrosis atrial fibrillation role tissue. relationship between factors disease development remains questionable requires further investigation. summarizes importance future studies parameters properties individuals with pathology.

Language: Английский

Citations

4
Relationships of pericoronary and epicardial fat measurements in male and female patients with and without coronary artery disease DOI Creative Commons
Runlei Ma, Marly van Assen, Grigory Sidorenkov

et al.

European Journal of Radiology, Journal Year: 2023, Volume and Issue: 169, P. 111154 - 111154

Published: Oct. 18, 2023

Although pericoronary adipose tissue (PCAT) is a component of the epicardial (EAT) depot, they may have different associations to coronary artery disease (CAD). We explored relationships between mean attenuation (PCAT

Language: Английский

Citations

2
Perivascular Adipose Tissue Density and Stenosis Plaque Degree in Lower Limb Peripheral Arteries in CT DOI Creative Commons

Alice Fortunati,

Chiara Perazzo,

M Basile

et al.

Journal of Vascular Diseases, Journal Year: 2024, Volume and Issue: 3(2), P. 224 - 234

Published: June 11, 2024

Background: Perivascular adipose tissue (PVAT) attenuation has emerged as a novel biomarker for identifying high-risk arterial plaques due to its association with inflammation. Recognizing the systemic nature of atherosclerosis and link major cardiovascular events in coronary disease, this study evaluated PVAT peripheral arteries using CT imaging expand understanding diagnostic prognostic potential. Methods: retrospective analysis 53 consecutive patients who underwent angiography, examining density across five primary segments. A 5 mm region interest adjacent vascular wall was analyzed by two blinded readers, reproducibility coefficients calculated determine reliability measurements. For statistical analyses, mean values were derived from these The stratified into four groups based on degree stenosis: <25%, 25–50%, 50–70%, >70%. comparisons between performed Kruskal–Wallis test pairwise Mann–Whitney U Holm–Bonferroni correction multiple comparisons. Results: revealed statistically significant disparities categorically differentiated stenosis (p < 0.001), indicating an severity. This especially pronounced external iliac, common femoral, superficial popliteal arteries, where p-values consistently below 0.05. Subsequent analyses utilizing affirmed findings, particular femoral 0.05). Conclusions: our findings reinforce correlation increased stenosis, supporting clinical value non-invasive risk stratification potentially guiding therapeutic interventions.

Language: Английский

Citations

0