Association between uric acid to high-density lipoprotein cholesterol ratio and chronic kidney disease in Chinese patients with type 2 diabetes mellitus: a cross-sectional study DOI Creative Commons
Xiangyu Chen, Jie Zhang, Feng Lü

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 14, 2025

Objectives To examine the association between uric acid (UA) to high-density lipoprotein cholesterol (HDL-C) ratio (UHR) and chronic kidney disease (CKD) in type 2 diabetes mellitus (T2DM) patients China. Methods The investigation stems from a survey conducted eastern Chinese province of Zhejiang, spanning March November 2018. A multivariable logistic regression model was employed assess relationship UHR CKD, while restricted cubic spline (RCS) analysis used evaluate dose–response relationship. Receiver operating characteristic (ROC) curve performed determine optimal cut-off value its diagnostic performance for CKD. Model further evaluated using net reclassification improvement (NRI) integrated discrimination (IDI) metrics. Sensitivity analyses, including propensity score matching (PSM) k-means clustering, were enhance robustness findings. Subgroup analyses across various demographic clinical categories consistency UHR-CKD association. Results This cross-sectional study included 1,756 with T2DM, among whom 485 (27.62%) identified Multivariable revealed significant positive Per standard deviation (SD) increase associated 40% higher odds CKD (OR = 1.40, 95% CI: 1.23–1.60) after adjusting potential covariates. When analyzed categorically, participants highest tertile (T3) had 1.82-fold compared lowest (T1) (95% 1.32–2.50). RCS demonstrated consistent linear all models (all p nonlinearity >0.05). ROC an 12.28 prediction, area under (AUC) 0.710 0.683–0.737) fully adjusted model. confirmed most variables, except younger age groups (18–44 45–59 years) smokers. Notably, BMI significantly modified relationship, nonlinear observed individuals lower (<24 kg/m ) those (≥24 ). Conclusion demonstrates highlighting as promising biomarker risk assessment. offers practical threshold early renal monitoring targeted interventions. Future research should explore UHR-targeted therapies integration into personalized stratification improve management T2DM.

Language: Английский

A promising strategy for assessing the uricosuric effect of anti-hyperuricemia candidates: a case study of caffeoylquinic acids extract of Artemisia selengensis Turcz. leaves DOI Creative Commons
Xiang Lin,

Mohammed Mansour,

Yuting Huang

et al.

Food, Nutrition and Health., Journal Year: 2025, Volume and Issue: 2(1)

Published: Feb. 27, 2025

Abstract Caffeoylquinic acids (CQAs) are phenolic found in various plants that possess multiple biological activities including anti-oxidation, anti-inflammation, and xanthine oxidase inhibitory activity. Our previous research demonstrated CQAs-rich Artemisia selengensis Turcz. leaves extract (ASTLE) effectively lowered uric acid levels hyperuricemia mice. However, further evidence is needed to elucidate the mechanism of acid-lowering effect ASTLE. In this study, a sensitive but non-radioactive vitro method based on 6-carboxyfluorescein (6-CFL) was established, validated, applied assess uricosuric potential Furthermore, molecular docking, qRT-PCR, western blot were employed The results ASTLE exhibited inhibit reabsorption, manifested as inhibition 6-CFL uptake by human kidney 2 (HK-2) cells (IC 50 = 533.67 ± 19.91 µg/mL), CQAs identified its dominant bioactive compounds. Mechanism investigation revealed attributed hydrogen bonding interactions CQAs, particularly di-CQAs, with transporters URAT1 GLUT9, well down-regulation mRNA protein expression GLUT9 up-regulation ABCG2 This study indicated has potent effect. Moreover, suggested combination assessment, analysis could be promising strategy for revealing role anti-hyperuricemia candidates promoting excretion. Graphical

Language: Английский

Citations

0
Serum uric acid level is associated with renal arteriolar hyalinosis and predicts post-donation renal function in living kidney donors DOI Creative Commons

Yuzuki Kano,

Katsuyuki Tanabe, Masashi Kitagawa

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0320482 - e0320482

Published: March 25, 2025

Major guidelines for living-donor kidney transplantation underscore the need pre-donation evaluation of renal function, hypertension, obesity, diabetes mellitus, and albuminuria to minimize risk donation from marginal donors. However, validity is yet be established. We retrospectively investigated relationship between clinical characteristics histological indices in baseline biopsies (0-h biopsies) whether these parameters could predict function living donors one year post-donation. Seventy-six were recruited this study. In analyses, glomerulosclerosis, arteriosclerosis, arteriolosclerosis, arteriolar hyalinosis, interstitial fibrosis tubular atrophy scores/indices evaluated. Post-donation serum creatinine levels with hyalinosis significantly higher than those individuals without hyalinosis. There was a significant correlation uric acid index, level identified as an independent factor multiple regression analysis. Additionally, prognostic post-donation after adjustment parameters. These data demonstrate that are associated decline during first

Language: Английский

Citations

0
Assessing cross-national inequalities and predictive trends in gout burden: a global perspective (1990–2021) DOI Creative Commons
Mingyang Li,

Qilong Nie,

Qixing Xia

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 27, 2025

Background Gout, caused by hyperuricemia and the deposition of monosodium urate crystals in joints, remains a major global health issue. Despite progress treatment, its prevalence continues to rise, contributing comorbidities like cardiovascular chronic kidney diseases. Understanding trends sociodemographic disparities is crucial for developing targeted interventions. Methods We analyzed gout prevalence, incidence, disability-adjusted life years (DALYs) from 1990 2021, stratified age, sex, economic development. Decomposition analysis quantified impact demographic factors, while advanced assessed relationship between burden socioeconomic Prediction models forecasted future trends, cross-national inequalities were evaluated highlight across regions with different development levels. Results Between increased 22,264,515 (95% UI: 17,793,190–27,965,605) 56,474,572 45,161,987–70,288,316), age-standardized rate (ASPR) rising 536.54 653.82 per 100,000 population [(Estimated annual percentage changes) EAPC: 0.87%, 95% CI: 0.80–0.95]. The incidence cases 136.1%, (ASIR) 17.12% over this period. Similarly, death (ASDR) grew 21.30%, accompanied substantial increase DALYs. revealed that aging significantly contributed Middle SDI (36.79%), growth was dominant factor Low (98.58%). Advanced indicated gaps observed optimal levels high-SDI countries, such as United States Australia, highlighting unrealized opportunities improving outcomes. projected stable 2021 2045, notable gender-specific age-specific trends. Cross-national inequality showed worsening DALYs high- low-SDI regions, reflected increasing Slope Index Inequality Health Concentration values 2021. Conclusion has risen, facing risks lifestyle changes obesity, struggle healthcare access. Public strategies should focus on modifiable risk infrastructure, gender- address disparities.

Language: Английский

Citations

0
Febuxostat efficiently reduces the progression of chronic kidney disease in asymptomatic hyperuricemia: An interventional study DOI

Showkat Azad,

Pradip Kumar Dutta,

Md. Nurul Huda

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Background Therapeutic approaches for addressing asymptomatic chronic kidney disease (CKD) with renal impairment requires careful consideration, as there is a lack of substantial evidence endorsing specific medications. This study examined the outcomes administering febuxostat to persons diagnosed hyperuricemia in CKD (stages 3 and 4). Methods A single-patient blinded; placebo-controlled was carried out at Chittagong Medical College Hospital Chattogram 4203 over one-year period. Participants were randomly assigned two groups: one group received daily dose 40 mg while other given placebo tablets. As necessary, diuretics, antihypertensives, antidiabetics administered. Evaluations, which included patient history, physical examinations, outcomes, pertinent tests, performed baseline, 3rd month, 6th month. Results There 105 similar-baseline patients each group. The mean serum uric acid (SUA) level lowered from 8.55 4.92 mg/dL after six months, control it elevated 8.10 8.99. In group, eGFR 25.28 27.01 ml/min/1.73 m2, reduced 26.81 23.32. six-month mark, differed across groups following decrease systolic diastolic blood pressure (p < 0.05). Conclusions our clinical setting, proved more effective than reducing levels maintaining stage 4 CKD. Hence, could be employed treat hyperuricemia-associated disease.

Language: Английский

Citations

0
Association between uric acid to high-density lipoprotein cholesterol ratio and chronic kidney disease in Chinese patients with type 2 diabetes mellitus: a cross-sectional study DOI Creative Commons
Xiangyu Chen, Jie Zhang, Feng Lü

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 14, 2025

Objectives To examine the association between uric acid (UA) to high-density lipoprotein cholesterol (HDL-C) ratio (UHR) and chronic kidney disease (CKD) in type 2 diabetes mellitus (T2DM) patients China. Methods The investigation stems from a survey conducted eastern Chinese province of Zhejiang, spanning March November 2018. A multivariable logistic regression model was employed assess relationship UHR CKD, while restricted cubic spline (RCS) analysis used evaluate dose–response relationship. Receiver operating characteristic (ROC) curve performed determine optimal cut-off value its diagnostic performance for CKD. Model further evaluated using net reclassification improvement (NRI) integrated discrimination (IDI) metrics. Sensitivity analyses, including propensity score matching (PSM) k-means clustering, were enhance robustness findings. Subgroup analyses across various demographic clinical categories consistency UHR-CKD association. Results This cross-sectional study included 1,756 with T2DM, among whom 485 (27.62%) identified Multivariable revealed significant positive Per standard deviation (SD) increase associated 40% higher odds CKD (OR = 1.40, 95% CI: 1.23–1.60) after adjusting potential covariates. When analyzed categorically, participants highest tertile (T3) had 1.82-fold compared lowest (T1) (95% 1.32–2.50). RCS demonstrated consistent linear all models (all p nonlinearity &gt;0.05). ROC an 12.28 prediction, area under (AUC) 0.710 0.683–0.737) fully adjusted model. confirmed most variables, except younger age groups (18–44 45–59 years) smokers. Notably, BMI significantly modified relationship, nonlinear observed individuals lower (&lt;24 kg/m ) those (≥24 ). Conclusion demonstrates highlighting as promising biomarker risk assessment. offers practical threshold early renal monitoring targeted interventions. Future research should explore UHR-targeted therapies integration into personalized stratification improve management T2DM.

Language: Английский

Citations

0