Evolving Myocardial Injury in Chronic Kidney Disease Assessed by Multiparameter Magnetic Resonance in a Rabbit Model

Journal of Magnetic Resonance Imaging, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Early diagnosis and monitoring of chronic kidney disease (CKD)-related myocardial injury are crucial for improving outcomes. To evaluate tissue characteristics deformation during the occurrence evolution CKD in a rabbit model using multiparametric cardiac MRI. Longitudinal animal study. A total 26 rabbits (14 undergoing cationic bovine serum albumin (C-BSA) injection to induce CKD, 12 sham saline serve as controls). 3, cine, T1 mapping, T2 mapping sequences. Cardiac MRI was performed at baseline, 4, 6, 8 weeks both groups. Global radial, circumferential, longitudinal strain (GRS, GCS GLS, respectively), native T1, T2, extracellular volume (ECV) were assessed each time point. Collagen fraction (CVF) assessed, immunohistochemical staining IL-6 antibody. Pathology used reference standard comparison with findings. The diagnostic accuracy individual combined MR parameters detecting early CKD-related determined. Descriptive statistics, Spearman correlation (r), area under receiver operating characteristic curve (AUC). p-value < 0.05 considered statistically significant. Compared controls, GLS significantly lower, ECV higher group 4 post-injection. At 6 weeks, further reduced, values increased compared controls. Myocardial positively correlated CVF (r = 0.584 0.754, 0.661). combination showed superior subclinical single indicators (AUC 0.846, 95% CI: 0.731-0.962). appropriate MRI-based features strain, fibrosis, inflammation may an marker injury. N/A. Stage 2.

Language: Английский

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Prognosis of non-albuminuric patients with the cardiovascular-kidney-metabolic syndrome

Clinical Kidney Journal, Journal Year: 2025, Volume and Issue: 18(4)

Published: March 12, 2025

Cardiovascular-kidney-metabolic (CKM) syndrome affects a significant portion of the general population. Urinary albumin-to-creatinine ratio (UACR) is an important indicator kidney injury. While some studies have indicated associations between UACR within normal range and mortality outcomes, it remains uncertain whether traditionally could help to distinguish prognosis CKM patients. This cohort study included patients with at stages 2 3 from China Renal Data System (CRDS) UK Biobank (UKB) databases. was treated as continuous variable categorized into low-normal high-normal. The were initially assessed in CRDS database subsequently validated UKB database. Multivariable Cox proportional hazards regression employed estimate UACR. Additionally, subgroup analyses sensitivity conducted enhance robustness results. encompassed total 14 602 82 694 Near-linear identified levels progression stage 4, well all-cause mortality. When compared group, individuals high-normal exhibited elevated risk 4 (HR 1.133, 95% CI 1.026-1.250) increased 2.321, 1.679-3.208) These further corroborated Consistent findings also observed through analyses. indicate that are significantly associated poor among 3. results underscore critical role identifying high-risk populations, particularly metabolic disorders. information may prove valuable for monitoring implementing intervention strategies

Language: Английский

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Breastfeeding and Future Cardiovascular, Kidney, and Metabolic Health—A Narrative Review

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 995 - 995

Published: March 12, 2025

The benefits of breastfeeding for both mother and infant are generally recognized; however, the connections between breast milk, lactation, long-term offspring health disease remain incompletely understood. Cardiovascular–kidney–metabolic syndrome (CKMS) has become a major global public challenge. Insufficient milk supply, combined with various early-life environmental factors, markedly increases future risk CKMS, as highlighted by developmental origins (DOHaD) concept. Given its richness in nutrients bioactive components essential health, this review focuses on reprogramming strategies involving to improve offspring’s cardiovascular, kidney, metabolic health. It also highlights recent experimental advances understanding mechanisms driving CKMS programming. Cumulatively, evidence suggests that lactational impairment heightens development. In contrast, early interventions during lactation period focused animal models leverage response cues show potential improving outcomes—an area warranting further investigation clinical translation.

Language: Английский

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Chronic kidney disease is no longer a ‘non-traditional’ cardiac risk factor: a call to action for cardiovascular-kidney-metabolic health

Singapore Medical Journal, Journal Year: 2025, Volume and Issue: 66(3), P. 122 - 124

Published: March 1, 2025

Language: Английский

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The impact of the Red Blood Cell Distribution Width/Albumin Ratio on All-Cause and Cardiovascular Mortality in Patients with Cardiovascular-Kidney-Metabolic Syndrome: Evidence from NHANES 2009– 2018

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Background: The ratio of red blood cell distribution width (RDW) to albumin (RAR) has been demonstrated have prognostic value in various diseases. However, its association with mortality patients Cardiovascular-Kidney-Metabolic Syndrome (CKM) remains unclear. This study aims investigate the RAR all-cause and cardiovascular CKM patients. Methods: This analyzed 10,234 from National Health Nutrition Examination Survey (NHANES) database for years 2009-2018. Mortality outcomes were determined based on records Death Index (NDI) as December 31, 2019. Cox proportional hazards regression model was used evaluate relationship between risk. Additionally, this further explored using Kaplan-Meier curve restricted cubic spline (RCS) models, while adjusting potential confounding factors. Results: In population, proportions stages 1, 2, 3, 4 syndrome 23.75%, 60.13%, 5.85%, 10.27% respectively, females accounting 49.58%, average age being 49.6 years. After grouping by quartiles levels (Q1-Q4), multivariate analysis indicated that compared Q1 group, risk Q4 group increased 3.12 times (HR=3.12, 95% CI 2.16-4.50, P<0.001), 2.24 (HR=2.24, 1.21-4.16, P=0.011). For each standard deviation increase RAR, 54% (HR=1.54, 1.37-1.72, 52% (HR=1.52, 1.30-1.77, P<0.001). confirmed a significantly lower survival rate groups higher RCS validated linear positive correlation Conclusions: Elevated are associated an finding suggests could serve valuable biomarker assessing prognosis patients, providing basis clinical stratification early intervention.

Language: Английский

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Cardiovascular–Kidney–Metabolic Syndrome: A New Paradigm in Clinical Medicine or Going Back to Basics?

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(8), P. 2833 - 2833

Published: April 19, 2025

Cardiovascular, renal, and metabolic diseases are pathophysiologically interdependent, posing a significant global health challenge being associated with substantial increase in morbidity mortality. In 2023, the American Heart Association (AHA) defined this complex network of interconnected conditions as cardiovascular–kidney–metabolic (CKM) syndrome. This syndrome is based on common pathophysiological mechanisms, including chronic inflammation, oxidative stress, hyperglycemia insulin resistance, activation renin–angiotensin–aldosterone system (RAAS), neurohormonal dysfunction, which trigger vicious cycle where impairment one organ contributes to progressive deterioration others. An integrated approach these conditions, rather than treating them separate entities, supports holistic management strategy that helps reduce burden public improve patients’ quality life. Existing focuses lifestyle modification, glycemic lipid control, use nephroprotective cardioprotective therapies. narrative review aims synthesize contextualize existing information interactions between systems diagnostic approaches, well provide an overview available therapeutic options.

Language: Английский

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Advancing Cardiovascular, Kidney, and Metabolic Medicine: A Narrative Review of Insights and Innovations for the Future

Diabetes Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Cardiovascular, kidney and metabolic (CKM) conditions are interrelated, significantly contributing to morbidity, mortality healthcare burden. Despite therapeutic advances, traditional disease-specific approaches often fail address their complex interplay. Key agents-including glucagon-like peptide-1 receptor agonists (GLP-1 RAs), dual GLP-1/glucose-dependent insulinotropic polypeptide RAs, sodium glucose co-transporter inhibitors the nonsteroidal mineralocorticoid antagonist (MRA) finerenone-offer multi-organ benefits. Emerging therapies, such as triple second-generation MRAs, target new pathways further expanding treatment options for CKM conditions. A holistic management approach must recognise that dysfunction-associated steatotic liver disease, steatohepatitis, obstructive sleep apnoea obesity part of spectrum. Frailty assessment is also important alongside conditions, warranting comprehensive geriatric deprescribing when appropriate. Multidisciplinary care-including lifestyle interventions, pathway redesign, pharmacological advances novel technologies-is essential improving outcomes. As landscape evolves, future strategies should prioritise early intervention, personalised addressing unmet needs in high-risk populations. This review advocates an integrated framework, exploring strategies, emerging therapies technological innovations. It examines role artificial intelligence digital health tools risk stratification, diagnosis long-term condition management, ethical regulatory considerations.

Language: Английский

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