Association of Polycystic Ovary Syndrome with Clinical, Physical, and Reproductive Factors: A Data-Driven Analysis

Diagnostics, Journal Year: 2025, Volume and Issue: 15(6), P. 711 - 711

Published: March 12, 2025

Background/Objectives: Polycystic Ovary Syndrome (PCOS) is a multifactorial endocrine disorder with significant clinical and reproductive implications. Identifying dose–response relationships between clinical, physical, factors PCOS can enhance diagnostic accuracy inform treatment strategies. This study utilized data-driven approach to analyze the associations key factors, including age, weight, menstrual cycle length, Anti-Mullerian Hormone (AMH) levels, follicle count, prevalence. Methods: A retrospective analysis was conducted on dataset of 539 participants determine optimal ranges these associated an increased likelihood diagnosis. Statistical analyses were using Python, correlation matrix, univariate multivariate logistic regression, evaluations. Results: Our findings demonstrated that risk increases positively in women under 32 years age. AMH levels above 4.18 ng/mL strongly PCOS, suggesting higher may reflect excessive follicular activity rather than enhanced ovarian function. Weight correlated emphasizing role metabolic disturbances its pathophysiology. Additionally, length exhibited non-linear association both shortened prolonged cycles being indicative hormonal dysregulation. count consistently linked reinforcing significance. Conclusions: provides evidence factors. The proposed serve as valuable reference points for clinicians, aiding early diagnosis personalized management strategies PCOS.

Language: Английский

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The Anti-Mullerian Hormone as a Biomarker of Effectiveness of Metformin Hydrochloride Therapy in Polycystic Ovarian Syndrome and Insulin Resistance

Healthcare, Journal Year: 2025, Volume and Issue: 13(8), P. 884 - 884

Published: April 11, 2025

Background/Objectives: Among the therapeutic options available for managing PCOS, metformin improves insulin sensitivity, reduces androgen levels, and helps restore menstrual regularity ovulation. While primarily used its metabolic effects, therapy may also influence reproductive parameters, including AMH which are pivotal in improving ovarian function predicting outcomes PCOS. The aim of this study was to search scientific literature analyze correlation between levels hydrochloride women with PCOS IR. Methods: A systematic review conducted using following keywords: polycystic syndrome, anti-Mullerian hormone, resistance, metformin, treatment, biomarker, syndrome. This aimed at investigating potential as a biomarker effectiveness patients Results: Metformin treatment has shown significant reductions serum prolonged therapy. As an sensitizer, hyperinsulinemia, suppresses hyperandrogenism. process inhibits growth antral follicles, is reflected decreased levels. Conclusions: Reductions improvements sensitivity can serve indicators efficacy enhancements these patients. could be considered prognostic marker evaluating decrease indicate improved reduction morphology. However, further research necessary confirm findings determine optimal dosages duration treatment.

Language: Английский

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Reducing the Risk of Pre-Eclampsia in Women with Polycystic Ovary Syndrome Using a Combination of Pregnancy Screening, Lifestyle, and Medical Management Strategies

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(6), P. 1774 - 1774

Published: March 20, 2024

Polycystic ovary syndrome (PCOS) is a multisystem disorder that presents with variety of phenotypes involving metabolic, endocrine, reproductive, and psychological symptoms signs. Women PCOS are at increased risk pregnancy complications including implantation failure, miscarriage, gestational diabetes, fetal growth restriction, preterm labor, pre-eclampsia (PE). This may be attributed to the presence specific susceptibility features associated before during pregnancy, such as chronic systemic inflammation, insulin resistance (IR), hyperandrogenism, all which have been an complications. Many reversible following lifestyle interventions diet exercise, pregnant women healthy found lower complications, PE. narrative synthesis summarizes evidence investigating PE role nutritional factors in PCOS. The findings suggest beneficial aspects management PCOS, recommended evidence-based international guidelines, extend improved outcomes. Identifying high-risk will allow targeted interventions, early-pregnancy screening, surveillance for should included assessment algorithms

Language: Английский

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Evaluation of Retinal Changes in Women with Different Phenotypes of Polycystic Ovary Syndrome

Diagnostics, Journal Year: 2025, Volume and Issue: 15(2), P. 227 - 227

Published: Jan. 20, 2025

Background: The aim of our study was to evaluate the retinal nerve fiber layer (RNFL) and macular choroidal thicknesses in women with different phenotypes polycystic ovary syndrome (PCOS), compare these measurements those healthy reproductive age. Materials Methods: This prospective case–control included 120 eyes PCOS, each four distinct comprising 30 women. Additionally, from were control group. All participants underwent comprehensive ophthalmologic examinations, RNFL thickness, thickness (MT), (CT) eye measured via spectral-domain optical coherence tomography. body mass index (BMI) patients recorded compared changes. Results: average mean nasal segments significantly greater PCOS group than (p < 0.001). There a statistically significant difference foveal between groups Our revealed tissue thickening subfoveally at locations 500 μm temporal, nasal, 1500 temporal fovea all there positive correlation BMI CT Conclusions: findings indicate that layers choroid are affected by one most common abnormalities, albeit varying degrees. Furthermore, changes found be correlated BMI.

Language: Английский

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Impact of Metformin Therapy on Chronic Inflammatory Markers Serum Fractalkine and CRP Levels in Polycystic Ovary Syndrome: A Pilot Study on Chronic Inflammatory Markers and Clinical Outcomes

The Journal of Obstetrics and Gynecology of India, Journal Year: 2025, Volume and Issue: 75(2), P. 115 - 121

Published: Feb. 13, 2025

Language: Английский

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Optimized derivative fast Fourier transform: Splitting singlet-appearing resonances to genuine multiplets in ovarian NMR spectra from encoded time signals

Journal of Mathematical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Language: Английский

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Therapeutic potential of fennel essential oil and manganese in modulating steroidal hormonal imbalance and ovarian alterations in rats with polycystic ovarian syndrome: An experimental study

International Journal of Reproductive BioMedicine (IJRM), Journal Year: 2025, Volume and Issue: 23(1), P. 79 - 90

Published: Feb. 24, 2025

Background: Polycystic ovarian syndrome (PCOS) is a prevalent hormonal disorder among women of reproductive age, resulting in female infertility. Researchers are exploring safe and affordable treatments for this disorder. Objective: This study explored the therapeutic effects fennel essential oil (FEO) manganese (Mn) on histological markers rats with estradiol valerate-induced PCOS. Materials Methods: In experimental study, 35 adult Wistar (9 wk old, 200–250 gr) were divided into 7 groups. For 14 days, groups 1–4 received normal saline intraperitoneally, sesame intramuscularly, FEO Mn orally, respectively. PCOS was induced remaining through single intramuscular injection valerate. 60 days after induction, 6th 7th treated individually intraperitoneal oral days. Blood samples analyzed estrogen, progesterone, malondialdehyde (MDA) markers. The tissues histologically examined to assess cyst formation structural changes. Results: significantly increased estrogen progesterone levels compared group (p ≤ 0.05). also elevated levels, but change not statistically significant > No differences MDA observed between PCOS+FEO Although decreased PCOS+Mn group, reduction Both reduced numbers untreated Conclusion: demonstrated potential restoring balance improving histology, offering promise as low-cost

Language: Английский

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Association of Pelvic Floor Dysfunction with Conception Challenges Among PCOS Female

Pakistan BioMedical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 18 - 22

Published: March 31, 2025

Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder in women, often linked to reproductive challenges and pelvic floor dysfunction. Objective: To find out the association of dysfunction with conception among females Poly Cystic Syndrome. Methods: A cross sectional descriptive study was conducted; data were collected from Jinnah Hospital, Central Park Suraya Azeem teaching hospital private clinics Lahore. Data after getting approval University Research Ethical Committee July October 2024 Reference number RE-085-2024. Non probability purposive sampling technique used. Pelvic confirmed through inventedry-20 along some self-made questions for statistics.192 married female included analyzed SPSS version 22.0 software. Results: Out 192 respondents age group 21-30(68.2%). In distribution BMI, 91 (47.4%) overweight, 163 (84.9%) trying get pregnant, 170(88.5%) facing difficulty 169(88%) faced miscarriages, 72(37.5%) had 2 78(40.6%) 1 stillbirth, 83(43.2%) preterm birth, 154 (80.2%) taking treatment PCOS. 115(59.9%) severe organ prolapse, 135(70.3%) mild colorectal anal distress 97(50.5%) urinary distress. Conclusions: The concluded that there high prevalence PCOS females. Moreover, prolapse significantly associated miscarriages women

Language: Английский

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Advancing PCOS Diagnosis: Capsule Network-Based Classification using Ultrasound Images

Journal of Innovative Image Processing, Journal Year: 2025, Volume and Issue: 7(1), P. 226 - 247

Published: March 1, 2025

Capsule Networks have been developed as an alternative to Convolutional Neural (CNN) for encapsulating spatial hierarchies in images or signals. The objective is improve the precision of Polycystic Ovary Syndrome (PCOS) classification by sophisticated image processing methodologies. proposed system uses features examine medical ultrasound PCOS while improving feature protection. It creates a reliable diagnostic model capable accurately differentiating between healthy and PCOS. provide more detailed evaluations ovarian morphology preserving orientation positioning information characteristics. Three different capsule networks, such Dynamic Routing CapsNet (DRCN), Expectation-Maximization (EM) (EMRCN), Deep (DCN), are analyzed using than 3000 dataset. Results prove that Network achieves better overall accuracy 99.33 %, sensitivity 99.27 specificity 99.4 % compared other types networks. combination with imaging procedures presents promising framework timely precise diagnosis, thereby diminishing delays enhancing patient outcomes gynaecological healthcare systems.

Language: Английский

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Nutritional and herbal interventions for polycystic ovary syndrome (PCOS): a comprehensive review of dietary approaches, macronutrient impact, and herbal medicine in management

Journal of Health Population and Nutrition, Journal Year: 2025, Volume and Issue: 44(1)

Published: May 2, 2025

Polycystic Ovary Syndrome (PCOS) is a common health condition related to woman's hormonal problems. Hormonal imbalance, metabolic disorders, and an increased insulin level mainly characterize the ailment. This detailed review focuses on dietary strategies, macromolecules, herbal interventions that exception-ally work in PCOS treatment. Research has shown Mediterranean, low-glycemic index, ketogenic diets are modified with individuals mind best ways resolve resistance, obesity, lack of ovulation. The other nutrients affect glucose metabolism play role hormone regulation such as protein reduced refined carbs. Among different micronutrients, vitamin D, omega-3 fatty acids, inositol were be most vital supplements treatment PCOS-induced oxidative damage, hyperandrogenism, infertility. Not mention, cinnamon, curcumin, sage, fennel, traditional Chinese medicine among some remedies so far show good potential perfect complementary therapy tools they create better glycemic control, inflammation reduction, menstrual cycle regularization. Even though findings promising, current supply clinical trials for standardizing these nutritional protocols lacking. Overall, this report stresses fact customized, holistic diet regime women make them feel well live long healthy life.

Language: Английский

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