Gallstones in the Era of Metabolic Syndrome: Pathophysiology, Risk Prediction, and Management DOI Open Access
Ke Wang, Zhigang Liu,

Rongmei Tang

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Gallstone disease (GSD) and metabolic syndrome (MetS) are increasingly prevalent conditions with significant global health implications. Recent evidence highlights a strong epidemiological association between these disorders, driven by shared pathophysiological mechanisms. This review provides comprehensive analysis of the intricate relationship MetS GSD, focusing on role insulin resistance, dyslipidemia, obesity, gut microbiota dysbiosis in gallstone formation. An integrated model is proposed, linking disturbances to bile cholesterol supersaturation, gallbladder dysmotility, chronic inflammation. The also explores clinical implications, including risk prediction models based parameters, early detection biomarkers, targeted interventions such as lifestyle modifications, pharmacological therapies, microbiome modulation. By addressing underpinnings this synthesis offers foundation for developing preventive therapeutic strategies mitigate burden interconnected conditions. Future research directions outlined refine mechanistic insights improve outcomes.

Language: Английский

Gallstones in the Era of Metabolic Syndrome: Pathophysiology, Risk Prediction, and Management DOI Open Access
Ke Wang, Zhigang Liu,

Rongmei Tang

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Gallstone disease (GSD) and metabolic syndrome (MetS) are increasingly prevalent conditions with significant global health implications. Recent evidence highlights a strong epidemiological association between these disorders, driven by shared pathophysiological mechanisms. This review provides comprehensive analysis of the intricate relationship MetS GSD, focusing on role insulin resistance, dyslipidemia, obesity, gut microbiota dysbiosis in gallstone formation. An integrated model is proposed, linking disturbances to bile cholesterol supersaturation, gallbladder dysmotility, chronic inflammation. The also explores clinical implications, including risk prediction models based parameters, early detection biomarkers, targeted interventions such as lifestyle modifications, pharmacological therapies, microbiome modulation. By addressing underpinnings this synthesis offers foundation for developing preventive therapeutic strategies mitigate burden interconnected conditions. Future research directions outlined refine mechanistic insights improve outcomes.

Language: Английский

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