Langmuir, Journal Year: 2024, Volume and Issue: unknown

Published: July 18, 2024

The research focuses on optimizing the production of hydrogel microspheres using droplet microfluidics for pharmaceutical and bioengineering applications. A semiempirical method has been developed to predict dynamic interfacial tension at interface ion-cross-linked sodium alginate microsphere-sunflower oil modified with glacial acetic acid Tween 80 surfactant. These are produced in a small-scale coaxial device that is manufactured affordable DLP/LCD 3D printing technology transparent photopolymer. was tested design minireactor device, which allows fully cross-linked ready use output reactor without additional cross-linking steps microsphere collector. mathematical expression estimating moment formation includes Reynolds number two-phase liquid, Ohnesorge number, surface liquid–air continuous medium flow (modified oil). reliability prediction confirmed dispersed phase rates 0.8–3.2 0.01–0.08 mL/min, respectively. evolution from formed estimated ultimate hydrogel–modified system contributed reliable determination linear size minireactor. 76.5 ± 0.3 mN/m determined Young–Laplace equation, based measuring free energy as soft matter Owens-Wendt method. Additionally, equilibrium static contact angle wetted measured sessile drop From practical perspective, streamlining high-tech manufacturing polymer mini- microchannel devices applications suggested.

Language: Английский