Dissolvable microneedles in the skin: Determination the impact of barrier disruption and dry skin on dissolution DOI
Benchaphorn Limcharoen, Supason Wanichwecharungruang, Marius Kröger

et al.

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2024, Volume and Issue: 199, P. 114303 - 114303

Published: April 23, 2024

Language: Английский

3D PRINTING TECHNOLOGY IN MICRONEEDLES: AN EMERGING ERA IN TRANSDERMAL DRUG DELIVERY DOI Creative Commons

Manali D. Prajapat,

Amol D. Gholap, Snehal Shinde

et al.

Hybrid Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100447 - 100447

Published: March 1, 2025

Language: Английский

Citations

0
Effervescent Microneedles for the Codelivery of Chitosan Nanoparticles and Indocyanine Green To Enhance the Treatment of Diet-Induced Obesity in Mice DOI

Maoqi Luo,

Yunxiao Zhang,

Siwuxie He

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Obesity is a major global health challenge, significantly elevating the risk of cardiovascular disease and type II diabetes. In this study, we identified that self-assembled stearic-acid-modified chitosan oligosaccharide (COA) nanoparticles can efficiently degrade lipid droplets in adipocytes via autolysosomal pathways. By integrating COA with photothermal therapy (PTT), developed combination delivered through an effervescent microneedle (MN) patch for treating diet-induced obesity mice. The MN demonstrated superior skin penetration due to efficient separation needle tips from backing layer. Over four-week treatment period, nanoparticle indocyanine green coloaded patches dramatically reduced body weight white adipose tissue obese mice without affecting their food intake. Histological analysis further revealed droplet size increased expression UCP-1 within tissues vivo. Additionally, improved glucose metabolism insulin sensitivity These findings suggest patch, when combined localized PTT, effectively combat its associated metabolic complications mouse model. This approach presents promising alternative oral injectable loss medications, offering efficacy fewer side effects.

Language: Английский

Citations

0
Polymeric Microneedles for Biomedical Applications: Innovations in Transdermal Drug Delivery and Biosensing Technologies DOI
Wendel A. Alves, Jose E. U. Rojas,

Ana C. H. Castro-Kochi

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Language: Английский

Citations

0
Polymeric microneedle advancements in macromolecule drug delivery: current trends, challenges, and future perspectives DOI

Madhuchandra Kenchegowda,

Mohit Angolkar, Umme Hani

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Language: Английский

Citations

0
Dissolvable microneedles in the skin: Determination the impact of barrier disruption and dry skin on dissolution DOI
Benchaphorn Limcharoen, Supason Wanichwecharungruang, Marius Kröger

et al.

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2024, Volume and Issue: 199, P. 114303 - 114303

Published: April 23, 2024

Language: Английский

Citations

3