Materials Futures,
Journal Year:
2023,
Volume and Issue:
2(3), P. 032001 - 032001
Published: June 16, 2023
Abstract
Ultrasound
(US)
is
a
kind
of
acoustic
wave
with
frequency
higher
than
20
kHz.
Learning
from
the
echo
detection
ability
bats
and
dolphins,
scientists
applied
US
for
clinical
imaging
by
sending
out
waves
detecting
echoes
shifted
intensities
frequencies
human
tissue.
has
long
played
critical
role
in
noninvasive,
real-time,
low-cost
portable
diagnostic
imaging.
With
in-depth
study
multidisciplinary
fields,
US-responsive
materials
have
shown
practical
value
not
only
disease
diagnosis,
but
also
treatment.
In
this
review,
we
introduce
recently
proposed
representative
biomedical
applications,
including
therapeutic
applications.
We
focused
on
US-mediated
physicochemical
therapies,
such
as
sonodynamic
therapy,
high-intensity
ablation,
sonothermal
thrombolysis,
etc,
US-controlled
delivery
chemotherapeutics,
gases,
genes,
proteins
bacteria.
conclude
current
challenges
facing
translation
smart
prospects
future
development
medicine.
Biosensors,
Journal Year:
2022,
Volume and Issue:
12(11), P. 1023 - 1023
Published: Nov. 16, 2022
Both
passive
and
active
microfluidic
chips
are
used
in
many
biomedical
chemical
applications
to
support
fluid
mixing,
particle
manipulations,
signal
detection.
Passive
devices
geometry-dependent,
their
uses
rather
limited.
Active
include
sensors
or
detectors
that
transduce
chemical,
biological,
physical
changes
into
electrical
optical
signals.
Also,
they
transduction
detect
biological
applications,
highly
versatile
tools
for
disease
diagnosis
organ
modeling.
This
review
provides
a
comprehensive
overview
of
the
significant
advances
have
been
made
development
microfluidics
devices.
We
will
discuss
function
as
micromixers
sorters
cells
substances
(e.g.,
microfiltration,
flow
displacement,
trapping).
Microfluidic
fabricated
using
range
techniques,
including
molding,
etching,
three-dimensional
printing,
nanofabrication.
Their
broad
utility
lies
detection
diagnostic
biomarkers
organ-on-chip
approaches
permit
modeling
cancer,
well
neurological,
cardiovascular,
hepatic,
pulmonary
diseases.
Biosensor
allow
point-of-care
testing,
assays
based
on
enzymes,
nanozymes,
antibodies,
nucleic
acids
(DNA
RNA).
An
anticipated
field
includes
optimization
techniques
fabrication
biocompatible
materials.
These
developments
increase
versatility,
reduce
costs,
accelerate
time
technology.
Small,
Journal Year:
2023,
Volume and Issue:
20(9)
Published: Oct. 10, 2023
Abstract
Conductive
microfibers
play
a
significant
role
in
the
flexibility,
stretchability,
and
conductivity
of
electronic
skin
(e‐skin).
Currently,
fabrication
conductive
suffers
from
either
time‐consuming
complex
operations
or
is
limited
environments.
Thus,
it
presents
one‐step
method
to
prepare
hydrogel
based
on
microfluidics
for
construction
ultrastretchable
e‐skin.
The
are
achieved
with
MXene
cores
shells,
which
solidified
covalent
cross‐linking
between
sodium
alginate
calcium
chloride,
mechanically
enhanced
by
complexation
reaction
poly(vinyl
alcohol)
hydroxide.
microfiber
conductivities
tailorable
adjusting
flow
rate
concentration
core
shell
fluids,
essential
more
practical
applications
scenarios.
More
importantly,
patterned
e‐skin
can
be
constructed
combining
3D
printing
technology.
Because
great
advantages
mechanical
electrical
performance
microfibers,
shows
impressive
stretching
sensitivity,
also
demonstrate
attractive
application
values
motion
monitoring
gesture
recognition.
These
characteristics
indicate
that
has
potential
health
monitoring,
wearable
devices,
smart
medicine.
Applied Physics Reviews,
Journal Year:
2025,
Volume and Issue:
12(1)
Published: Jan. 21, 2025
Droplet
microfluidics
has
emerged
as
highly
relevant
technology
in
diverse
fields
such
nanomaterials
synthesis,
photonics,
drug
delivery,
regenerative
medicine,
food
science,
cosmetics,
and
agriculture.
While
significant
progress
been
made
understanding
the
fundamental
mechanisms
underlying
droplet
generation
microchannels
fabricating
devices
to
produce
droplets
with
varied
functionality
high
throughput,
challenges
persist
along
two
important
directions.
On
one
side,
generalization
of
numerical
results
obtained
by
computational
fluid
dynamics
would
be
deepen
comprehension
complex
physical
phenomena
microfluidics,
well
capability
predicting
device
behavior.
Conversely,
truly
three-dimensional
architectures
enhance
microfluidic
platforms
terms
tailoring
enhancing
flow
properties.
Recent
advancements
artificial
intelligence
(AI)
additive
manufacturing
(AM)
promise
unequaled
opportunities
for
simulating
behavior,
precisely
tracking
individual
droplets,
exploring
innovative
designs.
This
review
provides
a
comprehensive
overview
recent
applying
AI
AM
microfluidics.
The
basic
properties
multiphase
flows
production
are
discussed,
current
fabrication
methods
related
introduced,
together
their
applications.
Delving
into
use
technologies
topics
covered
include
AI-assisted
simulations
real-time
within
systems,
AM-fabrication
systems.
synergistic
combination
is
expected
active
matter
expediting
transition
toward
fully
digital
The Innovation,
Journal Year:
2023,
Volume and Issue:
4(3), P. 100421 - 100421
Published: April 6, 2023
Ultrasound
(US)
is
a
biofavorable
mechanical
wave
that
has
shown
practical
significance
in
biomedical
fields.
Due
to
the
cavitation
effect,
sonoluminescence,
sonoporation,
pyrolysis,
and
other
biophysical
chemical
effects,
wide
range
of
matters
have
been
elucidated
be
responsive
stimulus
US.
This
review
addresses
discusses
current
developments
US-responsive
matters,
including
US-breakable
intermolecular
conjugations,
US-catalytic
sonosensitizers,
fluorocarbon
compounds,
microbubbles,
US-propelled
micro-
nanorobots.
Meanwhile,
interactions
between
US
advanced
create
various
biochemical
products
enhanced
leading
exploration
potential
applications,
from
US-facilitated
biosensing
diagnostic
imaging
US-induced
therapeutic
applications
clinical
translations.
Finally,
challenges
are
summarized
future
perspectives
on
translations
proposed.
Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
33, P. 506 - 531
Published: Dec. 8, 2023
Intervertebral
disc
degeneration
(IVDD)
is
rising
worldwide
and
leading
to
significant
health
issues
financial
strain
for
patients.
Traditional
treatments
IVDD
can
alleviate
pain
but
do
not
reverse
disease
progression,
surgical
removal
of
the
damaged
may
be
required
advanced
disease.
The
inflammatory
microenvironment
a
key
driver
in
development
degeneration.
Suitable
anti-inflammatory
substances
are
critical
controlling
inflammation
IVDD.
Several
treatment
options,
including
glucocorticoids,
non-steroidal
drugs,
biotherapy,
being
studied
their
potential
reduce
inflammation.
However,
anti-inflammatories
often
have
short
half-life
when
applied
directly
quickly
excreted,
thus
limiting
therapeutic
effects.
Biomaterial-based
platforms
explored
as
anti-inflammation
strategies
treatment.
This
review
introduces
pathophysiology
discusses
therapeutics
components
these
unique
biomaterial
comprehensive
systems.
We
discuss
strengths,
shortcomings,
prospects
various
biomaterials
used
modulate
microenvironment,
providing
guidance
future
breakthroughs
Advanced Science,
Journal Year:
2023,
Volume and Issue:
11(5)
Published: Dec. 11, 2023
Abstract
Destruction
of
cartilage
due
to
the
abnormal
remodeling
subchondral
bone
(SB)
leads
osteoarthritis
(OA),
and
restoring
chondro‐bone
metabolic
homeostasis
is
key
treatment
OA.
However,
traditional
intra‐articular
injections
for
OA
cannot
directly
break
through
barrier
reach
SB.
In
this
study,
hydrothermal
method
used
synthesize
ultra‐small
size
(≈5
nm)
selenium‐doped
carbon
quantum
dots
(Se‐CQDs,
SC),
which
conjugated
with
triphenylphosphine
(TPP)
create
TPP‐Se‐CQDs
(SCT).
Further,
SCT
dynamically
complexed
hyaluronic
acid
modified
aldehyde
methacrylic
anhydride
(AHAMA)
construct
highly
permeable
micro/nano
hydrogel
microspheres
(SCT@AHAMA)
homeostasis.
vitro
experiments
confirmed
that
selenium
atoms
scavenged
reactive
oxygen
species
(ROS)
from
mitochondria
mononuclear
macrophages,
inhibited
osteoclast
differentiation
function,
suppressed
early
chondrocyte
apoptosis
maintain
a
balance
between
matrix
synthesis
catabolism.
vivo
further
demonstrated
delivery
system
osteoclastogenesis
H‐vessel
invasion,
thereby
regulating
initiation
process
inhibiting
degeneration
in
conclusion,
based
on
facilitate
efficient
penetration
articular
SB
regulate
metabolism
treatment.
Engineered Regeneration,
Journal Year:
2023,
Volume and Issue:
5(1), P. 45 - 55
Published: Nov. 26, 2023
Polyethylene
terephthalate
glycol,
PETG,
is
a
miscible,
transparent
thermoplastic
known
to
have
strong
tensile
properties,
high
ductility,
as
well
resistance
heat
and
chemical
insults.
PETG
may
be
manufactured
in
several
ways,
most
notably
3D
printing
modalities.
As
such,
has
emerged
viable
biomaterial
for
variety
of
medical
applications
such
tissue
engineering,
dentistry,
optometry,
vascular
health,
cardiology,
orthopedics,
neurology,
gynecology,
surgery.
also
serves
valuable
role
biomedical
research
engineering
by
offering
improvements
cell
studies,
drug
carriers,
anti-bacterial
measures.
Further
innovation
utilizing
will
better
characterize
its
value
an
inexpensive
versatile
biomaterial.
