A Bone‐Targeting Hydrogen Sulfide Delivery System for Treatment of Osteoporotic Fracture via Macrophage Reprogramming and Osteoblast‐Osteoclast Coupling DOI Open Access
Yi Qin, He Zhang, Xiaobin Guo

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

Abstract The demand for systemic treatment of osteoporotic fractures to reduce recurrence is increasing, but current anti‐osteoporosis medications exhibit unsatisfactory efficacy due adverse events and limited effects on fracture healing. Herein, a bone‐targeting zeolitic imidazolate framework‐8 (ZIF)‐based hydrogen sulfide (H 2 S) delivery system (ZIF‐H S‐SDSSD) designed simultaneously promote healing alleviate osteoporosis. With peptide SDSSD grafted the surface, ZIF‐H S‐SDSSD nanoparticles release H S in bone tissues without affecting serum level, thereby mitigating potential risks systematic delivery. Upon cellular uptake, acidic environment lysosomes drives from encapsulated zinc conjunction with degradation ZIF. synergistic released Zn 2+ macrophage metabolic reprogramming by suppressing succinate accumulation mitochondrial reactive oxygen species (mtROS) production, further regulate osteoblast‐osteoclast coupling. Overall, this strategy holds great promise clinical broadens application nanomedicine therapy orthopedic diseases.

Language: Английский

Unveiling the synergistic potential: Surface topology and osteogenic elements in biodegradable Zn alloys DOI
Xuan Yang,

Huafang Li

Surface and Coatings Technology, Journal Year: 2025, Volume and Issue: unknown, P. 132140 - 132140

Published: April 1, 2025

Language: Английский

Citations

0
Bioactive Glass Microscaffolds Fabricated by Two‐Photon Lithography DOI Creative Commons
Leonhard Hambitzer,

Jan Mathis Hornbostel,

L Roolfs

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract Porous scaffolds made of bioactive glass (BG) are great interest for tissue engineering as they can bond to bone rapidly and promote new formation. Pores channels between 100 500 µm provide space cell intrusion nutrient supply, facilitating ingrowth vascularization. Furthermore, smaller pores structural features a few microns in size influence behavior, such adhesion osteogenic differentiation. Additive manufacturing (AM) is well suited fabricate geometries. However, microstructuring BG demanding common AM techniques unable achieve below µm. In this work, two‐photon lithography (TPL) used the first time structure with single‐micron features. A composite containing nanoparticles structured using TPL thermally processed receive scaffolds. The study demonstrates vitro bioactivity simulated body fluid (SBF) cytocompatibility toward human mesenchymal stromal cells (MSCs), making it suitable material engineering. This process will open toolbox variety existing particles be shaped small 6 broaden understanding scaffold design on behavior.

Language: Английский

Citations

0
Challenges and Pitfalls of Research Designs involving Magnesium-Based Biomaterials: An Overview DOI Open Access
Nourhan Hassan, Thomas Krieg, Alexander Kopp

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6242 - 6242

Published: June 5, 2024

Magnesium-based biomaterials hold remarkable promise for various clinical applications, offering advantages such as reduced stress-shielding and enhanced bone strengthening vascular remodeling compared to traditional materials. However, ensuring the quality of preclinical research is crucial development these implants. To achieve implant success, an understanding cellular responses post-implantation, proper model selection, good study design are crucial. There several challenges reaching a safe effective translation laboratory findings into practice. The utilization Mg-based biomedical devices eliminates need biomaterial removal surgery post-healing mitigates adverse effects associated with permanent implantation. high corrosion rate implants poses unexpected degradation, structural failure, hydrogen evolution, alkalization, cytotoxicity. biocompatibility degradability materials based on magnesium have been studied by many researchers in vitro; however, evaluations addressing impact material vivo still be improved. Several animal models, including rats, rabbits, dogs, pigs, explored assess potential magnesium-based Moreover, strategies alloying coating identified enhance degradation transform opportunities. This review aims explore Mg across applications within (in vitro) vivo) models.

Language: Английский

Citations

2
A Bone‐Targeting Hydrogen Sulfide Delivery System for Treatment of Osteoporotic Fracture via Macrophage Reprogramming and Osteoblast‐Osteoclast Coupling DOI Open Access
Yi Qin, He Zhang, Xiaobin Guo

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

Abstract The demand for systemic treatment of osteoporotic fractures to reduce recurrence is increasing, but current anti‐osteoporosis medications exhibit unsatisfactory efficacy due adverse events and limited effects on fracture healing. Herein, a bone‐targeting zeolitic imidazolate framework‐8 (ZIF)‐based hydrogen sulfide (H 2 S) delivery system (ZIF‐H S‐SDSSD) designed simultaneously promote healing alleviate osteoporosis. With peptide SDSSD grafted the surface, ZIF‐H S‐SDSSD nanoparticles release H S in bone tissues without affecting serum level, thereby mitigating potential risks systematic delivery. Upon cellular uptake, acidic environment lysosomes drives from encapsulated zinc conjunction with degradation ZIF. synergistic released Zn 2+ macrophage metabolic reprogramming by suppressing succinate accumulation mitochondrial reactive oxygen species (mtROS) production, further regulate osteoblast‐osteoclast coupling. Overall, this strategy holds great promise clinical broadens application nanomedicine therapy orthopedic diseases.

Language: Английский

Citations

0