Unveiling the synergistic potential: Surface topology and osteogenic elements in biodegradable Zn alloys
Xuan Yang,
No information about this author
Huafang Li
No information about this author
Surface and Coatings Technology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 132140 - 132140
Published: April 1, 2025
Language: Английский
Bioactive Glass Microscaffolds Fabricated by Two‐Photon Lithography
Leonhard Hambitzer,
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Jan Mathis Hornbostel,
No information about this author
L Roolfs
No information about this author
et al.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 24, 2025
Abstract
Porous
scaffolds
made
of
bioactive
glass
(BG)
are
great
interest
for
tissue
engineering
as
they
can
bond
to
bone
rapidly
and
promote
new
formation.
Pores
channels
between
100
500
µm
provide
space
cell
intrusion
nutrient
supply,
facilitating
ingrowth
vascularization.
Furthermore,
smaller
pores
structural
features
a
few
microns
in
size
influence
behavior,
such
adhesion
osteogenic
differentiation.
Additive
manufacturing
(AM)
is
well
suited
fabricate
geometries.
However,
microstructuring
BG
demanding
common
AM
techniques
unable
achieve
below
µm.
In
this
work,
two‐photon
lithography
(TPL)
used
the
first
time
structure
with
single‐micron
features.
A
composite
containing
nanoparticles
structured
using
TPL
thermally
processed
receive
scaffolds.
The
study
demonstrates
vitro
bioactivity
simulated
body
fluid
(SBF)
cytocompatibility
toward
human
mesenchymal
stromal
cells
(MSCs),
making
it
suitable
material
engineering.
This
process
will
open
toolbox
variety
existing
particles
be
shaped
small
6
broaden
understanding
scaffold
design
on
behavior.
Language: Английский
Challenges and Pitfalls of Research Designs involving Magnesium-Based Biomaterials: An Overview
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 6242 - 6242
Published: June 5, 2024
Magnesium-based
biomaterials
hold
remarkable
promise
for
various
clinical
applications,
offering
advantages
such
as
reduced
stress-shielding
and
enhanced
bone
strengthening
vascular
remodeling
compared
to
traditional
materials.
However,
ensuring
the
quality
of
preclinical
research
is
crucial
development
these
implants.
To
achieve
implant
success,
an
understanding
cellular
responses
post-implantation,
proper
model
selection,
good
study
design
are
crucial.
There
several
challenges
reaching
a
safe
effective
translation
laboratory
findings
into
practice.
The
utilization
Mg-based
biomedical
devices
eliminates
need
biomaterial
removal
surgery
post-healing
mitigates
adverse
effects
associated
with
permanent
implantation.
high
corrosion
rate
implants
poses
unexpected
degradation,
structural
failure,
hydrogen
evolution,
alkalization,
cytotoxicity.
biocompatibility
degradability
materials
based
on
magnesium
have
been
studied
by
many
researchers
in
vitro;
however,
evaluations
addressing
impact
material
vivo
still
be
improved.
Several
animal
models,
including
rats,
rabbits,
dogs,
pigs,
explored
assess
potential
magnesium-based
Moreover,
strategies
alloying
coating
identified
enhance
degradation
transform
opportunities.
This
review
aims
explore
Mg
across
applications
within
(in
vitro)
vivo)
models.
Language: Английский
A Bone‐Targeting Hydrogen Sulfide Delivery System for Treatment of Osteoporotic Fracture via Macrophage Reprogramming and Osteoblast‐Osteoclast Coupling
Yi Qin,
No information about this author
He Zhang,
No information about this author
Xiaobin Guo
No information about this author
et al.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 23, 2024
Abstract
The
demand
for
systemic
treatment
of
osteoporotic
fractures
to
reduce
recurrence
is
increasing,
but
current
anti‐osteoporosis
medications
exhibit
unsatisfactory
efficacy
due
adverse
events
and
limited
effects
on
fracture
healing.
Herein,
a
bone‐targeting
zeolitic
imidazolate
framework‐8
(ZIF)‐based
hydrogen
sulfide
(H
2
S)
delivery
system
(ZIF‐H
S‐SDSSD)
designed
simultaneously
promote
healing
alleviate
osteoporosis.
With
peptide
SDSSD
grafted
the
surface,
ZIF‐H
S‐SDSSD
nanoparticles
release
H
S
in
bone
tissues
without
affecting
serum
level,
thereby
mitigating
potential
risks
systematic
delivery.
Upon
cellular
uptake,
acidic
environment
lysosomes
drives
from
encapsulated
zinc
conjunction
with
degradation
ZIF.
synergistic
released
Zn
2+
macrophage
metabolic
reprogramming
by
suppressing
succinate
accumulation
mitochondrial
reactive
oxygen
species
(mtROS)
production,
further
regulate
osteoblast‐osteoclast
coupling.
Overall,
this
strategy
holds
great
promise
clinical
broadens
application
nanomedicine
therapy
orthopedic
diseases.
Language: Английский