Gut microecology: effective targets for natural products to modulate uric acid metabolism

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 28, 2024

Gut microecology,the complex community consisting of microorganisms and their microenvironments in the gastrointestinal tract, plays a vital role maintaining overall health regulating various physiological pathological processes. Recent studies have highlighted significant impact gut microecology on regulation uric acid metabolism. Natural products, including monomers, extracts, traditional Chinese medicine formulations derived from natural sources such as plants, animals, microorganisms, also been investigated for potential modulating According to research, The stability is crucial link products maintain healthy metabolism reduce hyperuricemia-related diseases. Herein, we review recent advanced evidence revealing bidirectional between And separately summarize key extracts herbal both aspects. In addition,we elucidated important mechanisms secondary diseases through microecology, especially by composition microbiota, mucosal barrier, inflammatory response, purine catalyzation, associated transporters. This may offer novel insight into its disorders management highlight perspective exploring therapeutic drugs products.

Language: Английский

Gut microbiota differences, metabolite changes, and disease intervention during metabolic - dysfunction - related fatty liver progression

World Journal of Hepatology, Journal Year: 2025, Volume and Issue: 17(3)

Published: March 25, 2025

In the current era, metabolic dysfunction-associated steatotic liver disease (MASLD) has gradually developed into a major type of chronic that is widespread globally. Numerous studies have shown gut microbiota plays crucial and indispensable role in progression MASLD. Currently, become one important entry points for research this disease. Therefore, aim review to elaborate on further associations between MASLD, including changes differences healthy diseased liver. Meanwhile, considering fatty steatohepatitis are abnormal pathological states development exhibits different degrees fibrosis (such as mild severe fibrosis) during progression, we also conduct comparison these use them markers progression. It reveals production action mechanisms short-chain acids bile brought about by microbiota, impact lipopolysaccharide from Gram-negative bacteria addition, regulation inhibition related factors probiotics (including new-generation probiotics) will be explored, which help monitor patients with compositions future carry out personalized targeted therapies microbiota. This achieve progress preventing combating

Language: Английский

The immunomodulatory activities of a thermostable galacto-mannanase and their impact on the performance of weaned piglets

Animal Feed Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 116186 - 116186

Published: Dec. 1, 2024

Language: Английский