3D Printing and Electrospinning of Drug- and Graphene-Enhanced Polycaprolactone Scaffolds for Osteochondral Nasal Repair DOI Open Access
Izabella Rajzer, Anna Kurowska, Anna Nikodem

et al.

Materials, Journal Year: 2025, Volume and Issue: 18(8), P. 1826 - 1826

Published: April 16, 2025

A novel bi-layered scaffold, obtained via 3D printing and electrospinning, was designed to improve osteochondral region reconstruction. The upper electrospun membrane will act as a barrier against unwanted tissue infiltration, while the lower 3D-printed layer provide porous structure for ingrowth. Graphene integrated into scaffold its antibacterial properties, drug Osteogenon® (OST) added promote bone regeneration. composite scaffolds were subjected comprehensive physical, thermal, mechanical evaluations. Additionally, their biological functionality assessed by means of NHAC-kn cells. 0.5% graphene addition PCL significantly increased strain at break, enhancing material ductility. GNP also acted an effective nucleating agent, raising crystallization temperatures supporting mineralization. high surface area facilitated rapid apatite formation attracting calcium phosphate ions. This confirmed FTIR, µCT SEM analyses, which highlighted positive impact on mineral deposition. synergistic interaction between nanoplatelets created bioactive environment that enhanced cell adhesion proliferation, promoted superior formation. These findings highlight scaffold’s potential promising biomaterial repair regenerative medicine.

Language: Английский

3D Printing and Electrospinning of Drug- and Graphene-Enhanced Polycaprolactone Scaffolds for Osteochondral Nasal Repair DOI Open Access
Izabella Rajzer, Anna Kurowska, Anna Nikodem

et al.

Materials, Journal Year: 2025, Volume and Issue: 18(8), P. 1826 - 1826

Published: April 16, 2025

A novel bi-layered scaffold, obtained via 3D printing and electrospinning, was designed to improve osteochondral region reconstruction. The upper electrospun membrane will act as a barrier against unwanted tissue infiltration, while the lower 3D-printed layer provide porous structure for ingrowth. Graphene integrated into scaffold its antibacterial properties, drug Osteogenon® (OST) added promote bone regeneration. composite scaffolds were subjected comprehensive physical, thermal, mechanical evaluations. Additionally, their biological functionality assessed by means of NHAC-kn cells. 0.5% graphene addition PCL significantly increased strain at break, enhancing material ductility. GNP also acted an effective nucleating agent, raising crystallization temperatures supporting mineralization. high surface area facilitated rapid apatite formation attracting calcium phosphate ions. This confirmed FTIR, µCT SEM analyses, which highlighted positive impact on mineral deposition. synergistic interaction between nanoplatelets created bioactive environment that enhanced cell adhesion proliferation, promoted superior formation. These findings highlight scaffold’s potential promising biomaterial repair regenerative medicine.

Language: Английский

Citations

0