Synthetic Protocols and Applications of 1,2,5-Oxadiazoles: A Review DOI
Greesh Kumar, Rajnish Kumar, Avijit Mazumder

et al.

Letters in Organic Chemistry, Journal Year: 2023, Volume and Issue: 21(1), P. 55 - 65

Published: Sept. 11, 2023

Abstract: The 1,2,5-oxadiazole framework has garnered a lot of interest among many nitrogen heterocycles because its capacity to give off NO under physiological circumstances. Because this, major efforts by chemical scientists have been made create novel drug possibilities in medicinal, material, and agriculture science that include the NO-donor N-oxide subunit coupled known or possible pharmacophore C-C/C-N links using suitable spacer. In last few years, derivatives reported as good pharmacophores carbonic anhydrase inhibitors, antibacterial, vasodilating agents, antimalarial, anticancer, etc. presented manuscript, we reviewed granted patents (last 10 years), different synthetic strategies 27 years) 1,2,5- oxadiazoles their synthesis such cycloaddition, dimerization, cyclodehydration, condensation, thermolysis, nitration, oxidation, ring-conversion, These methods also analyzed for merits demerits. manuscript highlighted various applications derivatives. We hope researchers across scientific streams will benefit from review articles designing work related 1,2,5-oxadiazoles.

Language: Английский

Synthesis of N- and S-substituted arylglyoximes via transformations of 4-arylfuroxans DOI

Daniil A. Chaplygin,

Alexander А. Larin, Леонид Л. Ферштат

et al.

Russian Chemical Bulletin, Journal Year: 2022, Volume and Issue: 71(8), P. 1745 - 1749

Published: Aug. 1, 2022

Language: Английский

Citations

1
Synthetic Protocols and Applications of 1,2,5-Oxadiazoles: A Review DOI
Greesh Kumar, Rajnish Kumar, Avijit Mazumder

et al.

Letters in Organic Chemistry, Journal Year: 2023, Volume and Issue: 21(1), P. 55 - 65

Published: Sept. 11, 2023

Abstract: The 1,2,5-oxadiazole framework has garnered a lot of interest among many nitrogen heterocycles because its capacity to give off NO under physiological circumstances. Because this, major efforts by chemical scientists have been made create novel drug possibilities in medicinal, material, and agriculture science that include the NO-donor N-oxide subunit coupled known or possible pharmacophore C-C/C-N links using suitable spacer. In last few years, derivatives reported as good pharmacophores carbonic anhydrase inhibitors, antibacterial, vasodilating agents, antimalarial, anticancer, etc. presented manuscript, we reviewed granted patents (last 10 years), different synthetic strategies 27 years) 1,2,5- oxadiazoles their synthesis such cycloaddition, dimerization, cyclodehydration, condensation, thermolysis, nitration, oxidation, ring-conversion, These methods also analyzed for merits demerits. manuscript highlighted various applications derivatives. We hope researchers across scientific streams will benefit from review articles designing work related 1,2,5-oxadiazoles.

Language: Английский

Citations

0