Plastic nanoparticle toxicity is accentuated in the immune-competent inflamed intestinal tri-culture cell model

Nanotoxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: Jan. 22, 2025

Introduction: Important cell-based models of intestinal inflammation have been advanced in hopes predicting the impact nanoparticles on disease. We sought to determine whether a high level and extended exposure nanoplastic might result added caused by reported mouse model irritable bowel Methods: The cell consist Transwell©-type insert with filter membrane upon which lies biculture monolayer Caco-2 HT29-MTX-E12 made up barrier cells (apical compartment). This was exposed digested 40 nm diameter polymethacrylate (PMA) surface-functionalized COOH (PMA-) or NH2 (PMA+) at 'low level' (143 µg/cm2 surface area) 'high (571 µg/cm2) for 24 48 h. Beyond apical compartment well tissue culture plate, macrophages, previously differentiated from THP-1 (basolateral Thus, immune competent tri-cultures were examined as two models: healthy inflamed. inflamed model, having activated IFN-γ macrophages LPS expressed greater secretion pro-inflammation cytokines. Results: Sedimentation, Diffusion Dosimetry (ISDD) simulated that 8%-12% PMA deposited onto 24-48-h. structure disorganized both PMA, level, 48-h experiments. While neither amount nor duration influenced lactate dehydrogenase (LDH) only levels PMA- PMA+ experiments resulted significantly increased LDH secreted compared control. study is first show an additive intestine.

Language: Английский

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Opinions of parents and parents-to-be on micro- and nanoplastics: knowledge and willingness to implement change in Canada

Microplastics and Nanoplastics, Journal Year: 2025, Volume and Issue: 5(1)

Published: March 6, 2025

Macroplastics (and their degradation products) have been known to an impact on the ocean and land environment for over 50 years. With discovery of microplastics nanoplastics in human body, recent attention has focused potential health effects. Here, a survey was used gauge current state knowledge about willingness consider plastics-reduction actions 300 expecting parents and/or parents/guardians young children Canada. In total, 79% participants reported knowing what are 75% were aware significant environment. contrast, sources exposure plastics (e.g., household products, food, drinking water) preclinical research findings low. The majority (98%) willing making at least one change homes or daily habits reduce who more likely multiple changes behaviour. To facilitate environmental action, strategies email communication, blog, documentaries, social media posts) needed improve public effects associated with nanoplastics.

Language: Английский

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Exposure to microplastics during pregnancy and fetal liver function

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 294, P. 118099 - 118099

Published: April 1, 2025

Emerging evidence suggests that in-utero exposure to microplastics (MPs) may have physiological consequences for fetal development, yet human data remain limited. This study investigates the association between placental microplastic and umbilical liver enzyme levels as markers of hepatic function. A prospective cohort was conducted in Shenyang, China, including 1057 pregnant women. Placental quantification performed using LD-IR chemical imaging, targeting polyvinyl chloride (PVC), polypropylene (PP), polybutylene succinate (PBS). Umbilical cord blood collected at delivery, alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate (AST), gamma-glutamyl transferase (GGT) were analyzed biochemical assays. Associations assessed via multivariable regression models adjusting maternal socioeconomic confounders. Mixture effects examined Bayesian Kernel Machine Regression (BKMR) quantile g-computation (g-comp). detected most samples (PVC: 88.4 %, PP: 88.8 PBS: 89.1 %), with a median total MPs 12 particles per 10 g tissue (IQR: 8). Higher PVC significantly associated increased ALP (β = 28.07, 95 % CI: 6.65-49.49, p 0.01). PP correlated positively ALT 0.63, 0.01-1.25, 0.05) AST 3.42, 0.87-5.96, Both burden exhibited strong associations GGT elevation (p < analysis revealed significant overall on 30.04, 11.15-48.92, 0.01), 7.30, 4.33-10.27, 22.98, 7.49-38.46, showing suggestive positive trend. Our findings provide novel MP is altered levels, particularly ALP, AST, GGT, indicating potential impacts These results underscore need further investigation into underlying mechanisms long-term health implications prenatal exposure.

Language: Английский

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Detection of microplastics in the feline placenta and fetus

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0320694 - e0320694

Published: April 2, 2025

The present study aimed to detect microplastics in feline placentas and fetuses the early stage of pregnancy. For this study, 8 pregnant queens were evaluated. A standardized protocol for digestion biological matter was used, as well a plastic-free approach sample collection manipulation. Microplastics investigated by means Raman spectroscopy, with aim identifying their composition. Four eight animals contaminated, total 19 detected both fetal placental samples. Specifically, from cats 4 7 5, 6, 7. This work demonstrates that can accumulate even at Moreover, preliminary results presence are shown, suggesting cross barrier.

Language: Английский

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The effects of exposure to microplastics on female reproductive health and pregnancy outcomes: A systematic review and meta-analysis

Reproductive Toxicology, Journal Year: 2025, Volume and Issue: 135, P. 108932 - 108932

Published: April 25, 2025

Language: Английский

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Mapping micro(nano)plastics in various organ systems: their emerging links to human diseases?

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 118114 - 118114

Published: Dec. 1, 2024

Language: Английский

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Impacts of Microplastic Pollution on the Environment and its Effective Treatment – A Review

Water Air & Soil Pollution, Journal Year: 2024, Volume and Issue: 235(8)

Published: July 3, 2024

Language: Английский

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Polystyrene microplastics exposition on human placental explants induces time-dependent cytotoxicity, oxidative stress and metabolic alterations

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 20, 2024

Microplastics (MPs) are environmental pollutants that pose potential risks to living organisms. MPs have been shown accumulate in human organs, including the placenta. In this study, we investigated biochemical impact of 5 μm polystyrene microplastics (PS-MPs) on term placental chorionic villi explants, focusing cytotoxicity, oxidative stress, metabolic changes, and for cross barrier.

Language: Английский

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Effect of Indonesian Bay Leaf Extract Preparation on the Barrier of Red Ray Transmission of Polyvinyl Alcohol Blend-Film

Lecture notes in networks and systems, Journal Year: 2024, Volume and Issue: unknown, P. 343 - 350

Published: Jan. 1, 2024

Language: Английский

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