Environmental Sciences Europe,
Journal Year:
2019,
Volume and Issue:
31(1)
Published: July 15, 2019
Non-target
screening
(NTS)
including
suspect
with
high
resolution
mass
spectrometry
has
already
shown
its
feasibility
in
detecting
and
identifying
emerging
contaminants,
which
subsequently
triggered
exposure
mitigating
measures.
NTS
a
large
potential
for
tasks
such
as
effective
evaluation
of
regulations
safe
marketing
substances
products,
prioritization
monitoring
programmes
assessment
environmental
quality.
To
achieve
this,
further
development
methodology
is
required,
including:
(i)
harmonized
protocols
quality
requirements,
(ii)
infrastructures
efficient
data
management,
sharing
(iii)
sufficient
resources
appropriately
trained
personnel
the
research
regulatory
communities
Europe.
Recommendations
achieving
these
three
requirements
are
outlined
following
discussion
paper.
In
particular,
order
to
facilitate
compound
identification
it
recommended
that
relevant
information
interpretation
spectra,
well
about
compounds
usage
production
tonnages,
should
be
made
accessible
scientific
community
(via
open-access
databases).
For
many
purposes,
implemented
combination
effect-based
methods
focus
on
toxic
chemicals.
Environmental Sciences Europe,
Journal Year:
2022,
Volume and Issue:
34(1)
Published: Oct. 21, 2022
Abstract
Background
The
NORMAN
Association
(
https://www.norman-network.com/
)
initiated
the
Suspect
List
Exchange
(NORMAN-SLE;
https://www.norman-network.com/nds/SLE/
in
2015,
following
collaborative
trial
on
non-target
screening
of
environmental
water
samples
by
mass
spectrometry.
Since
then,
this
exchange
information
chemicals
that
are
expected
to
occur
environment,
along
with
accompanying
expert
knowledge
and
references,
has
become
a
valuable
base
for
“suspect
screening”
lists.
NORMAN-SLE
now
serves
as
FAIR
(Findable,
Accessible,
Interoperable,
Reusable)
chemical
resource
worldwide.
Results
contains
99
separate
suspect
list
collections
(as
May
2022)
from
over
70
contributors
around
world,
totalling
100,000
unique
substances.
substance
classes
include
per-
polyfluoroalkyl
substances
(PFAS),
pharmaceuticals,
pesticides,
natural
toxins,
high
production
volume
covered
under
European
REACH
regulation
(EC:
1272/2008),
priority
contaminants
emerging
concern
(CECs)
regulatory
lists
partners.
Several
focus
transformation
products
(TPs)
complex
features
detected
environment
various
levels
provenance
structural
information.
Each
is
available
download.
merged,
curated
collection
also
Substance
Database
(NORMAN
SusDat).
Both
SusDat
integrated
within
System
(NDS).
individual
receive
digital
object
identifiers
(DOIs)
traceable
versioning
via
Zenodo
community
https://zenodo.org/communities/norman-sle
),
total
>
40,000
views,
50,000
downloads
40
citations
(May
2022).
content
progressively
into
large
open
databases
such
PubChem
https://pubchem.ncbi.nlm.nih.gov/
US
EPA’s
CompTox
Chemicals
Dashboard
https://comptox.epa.gov/dashboard/
enabling
further
access
these
lists,
additional
functionality
calculated
properties
resources
offer.
significant
annotation
NORMAN-SLE,
including
classification
browser
https://pubchem.ncbi.nlm.nih.gov/classification/#hid=101
).
Conclusions
offers
specialized
service
hosting
relevance
an
open,
manner
allows
integration
other
major
resources.
These
efforts
foster
between
scientists
regulators,
supporting
paradigm
shift
“one
substance,
one
assessment”
approach.
New
submissions
welcome
contacts
provided
website
Environment International,
Journal Year:
2022,
Volume and Issue:
164, P. 107234 - 107234
Published: April 15, 2022
In
this
study,
56
effluent
samples
from
52
European
wastewater
treatment
plants
(WWTPs)
were
investigated
for
the
occurrence
of
499
emerging
chemicals
(ECs)
and
their
associated
potential
risks
to
environment.
The
two
main
objectives
(i)
extend
our
knowledge
on
occurring
in
treated
wastewater,
(ii)
identify
prioritize
compounds
concern
based
three
different
risk
assessment
approaches
identification
consensus
mixture
drivers
concern.
Approaches
include
PNEC
EQS-based
regulatory
quotients
(RQs),
species
sensitivity
distribution
(SSD)-based
hazard
units
(HUs)
(iii)
toxic
(TUs)
biological
quality
elements
(BQEs)
algae,
crustacean,
fish.
For
purpose,
solid-phase
extracts
analysed
with
wide-scope
chemical
target
screening
via
liquid
chromatography
high-resolution
mass
spectrometry
(LC-HRMS),
resulting
366
detected
compounds,
concentrations
ranging
<
1
ng/L
>
100
µg/L.
categorized
respect
critical
information
relevant
management
prioritization
including:
(1)
frequency
occurrence,
(2)
measured
concentrations,
(3)
use
groups,
(4)
persistence
&
bioaccumulation,
(5)
modes
action.
A
comprehensive
using
RQ,
HU
TU
indicated
exceedance
thresholds
majority
effluents
RQ
being
most
sensitive
metric.
total,
299
out
identified
as
contributors
one
approaches,
while
32
established
high
concern,
including
a
percentage
(66%)
pesticides
biocides.
which
have
passed
an
advanced
ozonation
or
activated
carbon
(AC),
consistently
much
lower
estimated.
Frontiers in Microbiology,
Journal Year:
2023,
Volume and Issue:
14
Published: May 24, 2023
Antibiotics
are
an
essential
tool
of
modern
medicine,
contributing
to
significantly
decreasing
mortality
and
morbidity
rates
from
infectious
diseases.
However,
persistent
misuse
these
drugs
has
accelerated
the
evolution
antibiotic
resistance,
negatively
impacting
clinical
practice.
The
environment
contributes
both
transmission
resistance.
From
all
anthropically
polluted
aquatic
environments,
wastewater
treatment
plants
(WWTPs)
probably
main
reservoirs
resistant
pathogens.
They
should
be
regarded
as
critical
control
points
for
preventing
or
reducing
release
antibiotics,
antibiotic-resistant
bacteria
(ARB),
antibiotic-resistance
genes
(ARGs)
into
natural
environment.
This
review
focuses
on
fate
pathogens
Enterococcus
faecium
,
Staphylococcus
aureus
Clostridium
difficile
Acinetobacter
baumannii
Pseudomonas
aeruginosa
Enterobacteriaceae
spp.
(ESCAPE)
in
WWTPs.
All
ESCAPE
pathogen
species,
including
high-risk
clones
resistance
determinants
last-resort
antibiotics
such
carbapenems,
colistin,
multi-drug
platforms,
were
detected
wastewater.
whole
genome
sequencing
studies
demonstrate
clonal
relationships
dissemination
Gram-negative
species
via
hospital
effluents
enrichment
virulence
S.
enterococci
Therefore,
efficiency
different
processes
regarding
removal
clinically
relevant
ARB
ARGs,
well
influence
water
quality
factors
their
performance,
explored
monitored,
along
with
development
more
effective
treatments
appropriate
indicators
(ESCAPE
and/or
ARGs).
knowledge
will
allow
standards
point
sources
consolidate
WWTP
barrier
role
against
environmental
public
health
AR
threats.
Environmental Sciences Europe,
Journal Year:
2019,
Volume and Issue:
31(1)
Published: Sept. 30, 2019
Abstract
Currently,
chemical
monitoring
based
on
priority
substances
fails
to
consider
the
majority
of
known
environmental
micropollutants
not
mention
unexpected
and
unknown
chemicals
that
may
contribute
toxic
risk
complex
mixtures
present
in
environment.
Complementing
component-
effect-based
with
wide-scope
target,
suspect,
non-target
screening
(NTS)
high-resolution
mass
spectrometry
(HRMS)
data
is
recommended
support
impact
assessment.
This
will
allow
for
detection
newly
emerging
compounds
transformation
products,
retrospective
efforts,
identification
possible
drivers
toxicity
by
correlation
effects
or
modelling
expected
future
abatement
scenarios.
HRMS
becoming
increasingly
available
many
laboratories.
Thus,
time
right
establish
harmonize
methods,
train
staff,
record
samples
from
regular
events
surveys.
strongly
enhance
value
evaluating
pollution
problems,
at
limited
additional
costs.
Collaboration
exchange
a
European-to-global
scale
essential
maximize
benefit
screening.
Freely
accessible
platforms,
inter-laboratory
trials,
involvement
international
partners
networks
are
recommended.
Trends in Environmental Analytical Chemistry,
Journal Year:
2020,
Volume and Issue:
28, P. e00102 - e00102
Published: Sept. 3, 2020
The
number
of
chemicals
with
potential
to
reach
the
environment
is
still
largely
unknown,
which
poses
great
challenges
for
both
environmental
scientists
and
analytical
chemists.
Liquid
chromatography
coupled
high-resolution
mass
spectrometry
(LC-HRMS)
currently
instrumentation
choice
identification
wide-scope
polar
concern
(CECs)
in
water.
This
review
critically
evaluates
all
steps
involved
screening
CECs
water,
including
sampling
extraction,
analysis
by
LC-HRMS,
data
(pre-)treatment,
evaluation
reporting.
Passive
samplers
direct
injection,
combination
provide
new
opportunities
compared
conventional
grab
water
sampling,
as
do
instrumental
advances
such
ion-mobility
HRMS
(IM-HRMS).
In
this
paper,
we
argue
that
target,
suspect
non-target
should
not
be
viewed
three
separate
principles,
but
rather
conceptual
approaches
general
treatment
strategies
can
linked
together.
Due
large
amount
generated,
smart
prioritisation
are
needed,
particular
screening,
reduce
complexity
focus
on
high
interest.
We
evaluate
existing
consider
each
step
will
result
loss
(as
any
other
a
study),
requiring
compromises
depending
research
question
tackled.
Many
different
have
been
developed
recent
years,
structure
elucidation
remains
challenging
time-consuming
task.
discuss
current
future
trends,
e.g.
effect-based
methods
used
tools,
technological
like
IM-HRMS
improved
software
solutions
enable
strategies.
Environment International,
Journal Year:
2020,
Volume and Issue:
138, P. 105597 - 105597
Published: Feb. 29, 2020
The
occurrence
of
chemical
and
biological
contaminants
emerging
concern
(CECs)
was
investigated
in
treated
wastewater
intended
for
reuse
agriculture.
An
agarose
hydrogel
diffusion-based
passive
sampler
exposed
to
the
outlet
a
treatment
plant
(WWTP)
located
Cyprus,
which
is
equipped
with
membrane
bioreactor
(MBR).
Passive
samplers
triplicate
were
according
time-series
exposure
plan
maximum
duration
28
days.
Composite
flow-proportional
samples
collected
parallel
sampling
processed
by
solid
phase
extraction
using
HORIZON
SPE-DEX
4790
same
sorbent
material
(Oasis
HLB)
as
sampler.
analysis
enabled
(i)
field-scale
calibration
prototype
calculation
situ
rates
target
substances,
(ii)
investigation
silico
predicted
transformation
products
four
most
ecotoxicologically
hazardous
antibiotics
(azithromycin,
clarithromycin,
erythromycin,
ofloxacin).
Additionally,
subjected
seven
preselected
antibiotic
resistant
genes
(ARGs)
one
mobile
element
(int1).
All
extracts
analyzed
chemicals
single
batch
highly
sensitive
method
pharmaceuticals,
illicit
drugs
liquid
chromatography
tandem
MS/MS
(LC-QQQ)
various
other
compounds
(2316
total)
high-resolution
mass
spectrometry
(LC-HRMS).
279
CECs
all
ARGs
(except
blaCTX-M−32)
detected,
highlighting
potential
hazards
related
practices.
16
prioritized
following
ecotoxicological
risk
assessment,
whereas
sul1
(int1)
showed
highest
abundance.
Comprehensive
monitoring
efforts
novel
methods
such
sampling,
wide-scope
screening
molecular
are
required
assure
safe
application
avoid
spread
crop
uptake
potentially
chemicals.
Chemical Engineering Journal Advances,
Journal Year:
2022,
Volume and Issue:
10, P. 100245 - 100245
Published: Jan. 10, 2022
Water
pollution
is
the
most
serious
problem
threatening
global
water
resources.
The
release
of
both
natural
and
anthropogenic
factors
in
aquatic
environment
affecting
quality
bodies,
with
Contaminants
Emerging
Concern
(CECs)
being
one
major
issues.
In
recent
years,
availability
robust
sensitive
analytical
methods
has
allowed
detection
identification
a
wide
variety
pollutants.
Pharmaceutically
Active
Compounds
(PhACs)
represent
large
category
CECs
detected
environment,
posing
threats
to
human
health
ecosystems.
Hence,
there
an
urgent
need
for
better
understanding
their
environmental
occurrence,
fate,
exposure-associated
risks,
degradation
order
regulate
exposure
pharmaceuticals
environment.
This
review
covers
current
trends,
newly
developed
state-of-the-art
methods,
challenges
PhACs
different
matrices,
occurrence
patterns
We
also
make
compressive
assessment
ineffective
classic
drinking
treatment
plants
(DWTPs)
novel
technologies
such
as
membrane
filtration
advanced
oxidation
processes
that
have
been
implemented
upgrade
DWTPs.
Their
efficiency
removing
here
discussed,
well
other
embryonic
promising
solutions.
aim
this
article
provide
comprehensive
summary
pathways
fate
solutions
improving
monitoring
assessments
best
removal
plants.
