Co-exposure and health risks of several typical endocrine disrupting chemicals in general population in eastern China DOI

Xianping Wei,

Hu Yu, Qingqing Zhu

et al.

Environmental Research, Journal Year: 2021, Volume and Issue: 204, P. 112366 - 112366

Published: Nov. 11, 2021

Language: Английский

Bisphenol S interrupted axonogenesis on a human embryonic stem cells derived neural differentiation model: Conserved axon guidance and WNT signaling pathway involved DOI Creative Commons

Wan-Qing Guo,

Wei Xiong, Liang Wang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117854 - 117854

Published: Feb. 1, 2025

Language: Английский

Citations

0
Puerarin Attenuates the Cytotoxicity Effects of Bisphenol S in HT22 Cells by Regulating the BDNF/TrkB/CREB Signaling Pathway DOI Creative Commons

Meilin Qin,

Xinxin Guo, Nuo Xu

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 162 - 162

Published: Feb. 25, 2025

Bisphenol S (BPS) is a widespread environmental endocrine disrupter that can cause hepatotoxicity, neurotoxicity and negative effects on reproduction. Puerarin (PUE) has been found to have anti-inflammatory, antioxidant, neuroprotective properties, however, its potential protective against BPS-induced the underlying mechanisms are still not fully understood. In this study, HT22 cells were exposed different concentrations of BPS with or without PUE. Cell viability, apoptosis, oxidative damage, expression level axon-injury-related genes BDNF/TrkB/CREB pathway analyzed. The results showed 40 μM 180 100 PUE significantly decreased cell viability cells, but in 80 group, was higher than control ratio 1.1. Meanwhile, increased production ROS MDA GSH SOD. However, supplementation alleviated damage. also apoptosis rate induced by BPS. Additionally, levels mRNA proteins synaptic-related genes, inhibited signaling pathway. Interestingly, recover synaptic related upregulated conclusion, our study proved attenuate effect bisphenol S, which damage regulating This only first demonstrate mitigate through stress modulation, provides novel therapeutic approach involving These findings offer promising insights into natural-based strategies for protecting neurotoxins provide foundation future developments targeting neurotoxicity.

Language: Английский

Citations

0
Melatonin Improves Lactational Bisphenol S Induced Pre-Pubertal and Pubertal Testicular Impairments in Offspring DOI
Aishwarya Sahu, V. S. Malik, Rakesh Verma

et al.

Reproductive Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Language: Английский

Citations

0
The environmental occurrence, human exposure, and toxicity of novel bisphenol S derivatives: A review DOI
Ning Wu,

Yinling He,

Zhendong Sun

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 296, P. 118182 - 118182

Published: April 12, 2025

Language: Английский

Citations

0
Co-exposure and health risks of several typical endocrine disrupting chemicals in general population in eastern China DOI

Xianping Wei,

Hu Yu, Qingqing Zhu

et al.

Environmental Research, Journal Year: 2021, Volume and Issue: 204, P. 112366 - 112366

Published: Nov. 11, 2021

Language: Английский

Citations

25