International Journal of Hygiene and Environmental Health,
Journal Year:
2025,
Volume and Issue:
266, P. 114571 - 114571
Published: April 5, 2025
While
some
per-
and
polyfluoroalkyl
substances
(PFAS)
are
immunosuppressants,
whether
they
have
an
adverse
effect
on
infectious
disease
morbidity
is
unclear.
We
conducted
a
systematic
review
meta-analysis
of
epidemiologic
data
the
association
between
incremental
increase
in
serum
concentration
any
12
PFAS
risk
or
rate
(ID).
From
25
reports
representing
18
unique
study
populations,
we
meta-analyses
stratified
exposure
type
(log-transformed
absolute
scale)
outcome
(risk
rate).
To
synthesize
that
could
not
be
combined
with
due
to
different
types,
additionally
vote
counting
calculated
p-values.
A
small
positive
ID
was
more
frequently
reported
than
not,
though
synthesized
statistical
significance
present
only
few
instances.
The
p-value
analyses
had
many
similar
findings.
In
analyses,
statistically
significant
associations
were
noted
Perfluorononanoic
acid
lower
respiratory
tract
infection
(LRTI)
event
rates,
Perfluorooctanesulfonamide
LRTI
rates
combined,
Perfluorooctanoic
Perfluorodecanoic
all
Perfluoroundecanoic
risk.
identified
moderate
evidence
variable
size
but
usually
small;
certainty
was,
however,
generally
low
very
diminished
by
possible
influences
multiple
testing
covariance
among
results
accounted
for
analyses.
CRD42024551990.
Ecotoxicology and Environmental Safety,
Journal Year:
2023,
Volume and Issue:
270, P. 115851 - 115851
Published: Dec. 28, 2023
Maternal
endocrine
disrupting
chemicals
(EDCs)
exposure,
the
common
environmental
pollutants,
was
capable
of
involving
in
adverse
pregnancy
outcomes.
However,
evidence
their
connection
is
not
consistent.
Our
goal
to
comprehensively
explore
risk
EDCs
related
One
hundred
and
one
studies
were
included
from
two
databases
before
2023
association
between
outcomes
including
miscarriage,
small
for
gestational
age
(SGA),
low
birth
weight
(LBW)
preterm
(PTB).
We
found
that
maternal
PFASs
exposure
positively
correlated
with
PTB
(OR:1.13,
95%
CI:1.04–1.23),
SGA
(OR:1.10,
CI:1.04–1.16)
miscarriage
(OR:1.09,
CI:1.00–1.19).
The
pooled
estimates
also
showed
PAEs
linked
(OR:1.16,
CI:1.11–1.21),
(OR:1.20,
CI:1.07–1.35)
(OR:1.55,
CI:1.33–1.81).
In
addition,
some
specific
class
PFOS,
MBP,
MEHP,
DEHP,
BPA
associated
PTB.
PFOA,
PFHpA
SGA.
LBW.
MMP,
MEHHP,
MEOHP,
miscarriage.
PFASs,
may
increase
according
our
study.
limited
number
on
dose-response
hampered
further
explanation
causal
association.
Environmental Science and Pollution Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 8, 2025
Abstract
Exposome
represents
one
of
the
most
pressing
issues
in
environmental
science
research
field.
However,
a
comprehensive
summary
worldwide
human
exposome
is
lacking.
We
aimed
to
explore
bibliometric
characteristics
scientific
publications
on
exposome.
A
analysis
from
2005
December
2024
was
conducted
using
Web
Science
accordance
with
PRISMA
guidelines.
Trends/hotspots
were
investigated
keyword
frequency,
co-occurrence,
and
thematic
map.
Sex
disparities
terms
citations
examined.
From
2024,
931
published
363
journals
written
by
4529
authors
72
countries.
The
number
tripled
during
last
5
years.
Publications
females
(51%
as
first
34%
authors)
cited
fewer
times
(13,674)
than
males
(22,361).
Human
studies
mainly
focused
air
pollution,
metabolomics,
chemicals
(e.g.,
per-
polyfluoroalkyl
substances
(PFAS),
endocrine-disrupting
chemicals,
pesticides),
early-life
exposure,
biomarkers,
microbiome,
omics,
cancer,
reproductive
disorders.
Social
built
environment
factors,
occupational
multi-exposure,
digital
exposure
screen
use),
climate
change,
late-life
received
less
attention.
Our
results
uncovered
high-impact
countries,
institutions,
journals,
references,
authors,
key
trends/hotspots.
use
technologies
sensors,
wearables)
data
artificial
intelligence)
has
blossomed
overcome
challenges
could
provide
valuable
knowledge
toward
precision
prevention.
risk
scores
represent
promising
avenue.
American Journal of Industrial Medicine,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 5, 2025
Per-
and
polyfluoroalkyl
substances
(PFAS)
are
persistent
environmental
contaminants.
Previous
research
has
linked
PFAS
exposure
to
prostate
ovarian
cancer
risk,
however,
the
conclusions
have
been
inconsistent.
This
purpose
was
determine
relationship
between
at
population
level.
We
systematically
reviewed
three
databases-PubMed,
Web
of
Science,
Embase-for
from
when
these
databases
were
established
April
15,
2024.
The
quality
retrieved
evaluated
using
Newcastle-Ottawa
Scale
(NOS)
measurement
tool.
Meta-analysis
extracted
data
conducted
Stata
18.
also
sensitivity
subgroup
analyses,
as
well
Begg's
Egger's
tests.
Twelve
publications
involved
in
analysis
for
cancer,
six
included
ovary
cancer.
outcomes
indicated
that
PFOS
positively
related
(OR:
1.13,
95%
CI:
1.00-1.28),
while
mixed
1.63,
1.49-1.78).
source
heterogeneity
identified
primarily
attributable
variations
study
design.
No
significant
bias
detected
analysis.
demonstrated
an
association
both
cancers.
Further
investigation
is
required
clarify
underlying
mechanisms
potential
associations.
International Journal of Hygiene and Environmental Health,
Journal Year:
2025,
Volume and Issue:
266, P. 114571 - 114571
Published: April 5, 2025
While
some
per-
and
polyfluoroalkyl
substances
(PFAS)
are
immunosuppressants,
whether
they
have
an
adverse
effect
on
infectious
disease
morbidity
is
unclear.
We
conducted
a
systematic
review
meta-analysis
of
epidemiologic
data
the
association
between
incremental
increase
in
serum
concentration
any
12
PFAS
risk
or
rate
(ID).
From
25
reports
representing
18
unique
study
populations,
we
meta-analyses
stratified
exposure
type
(log-transformed
absolute
scale)
outcome
(risk
rate).
To
synthesize
that
could
not
be
combined
with
due
to
different
types,
additionally
vote
counting
calculated
p-values.
A
small
positive
ID
was
more
frequently
reported
than
not,
though
synthesized
statistical
significance
present
only
few
instances.
The
p-value
analyses
had
many
similar
findings.
In
analyses,
statistically
significant
associations
were
noted
Perfluorononanoic
acid
lower
respiratory
tract
infection
(LRTI)
event
rates,
Perfluorooctanesulfonamide
LRTI
rates
combined,
Perfluorooctanoic
Perfluorodecanoic
all
Perfluoroundecanoic
risk.
identified
moderate
evidence
variable
size
but
usually
small;
certainty
was,
however,
generally
low
very
diminished
by
possible
influences
multiple
testing
covariance
among
results
accounted
for
analyses.
CRD42024551990.