Influence of maternal endocrine disrupting chemicals exposure on adverse pregnancy outcomes: A systematic review and meta-analysis

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 270, P. 115851 - 115851

Published: Dec. 28, 2023

Maternal endocrine disrupting chemicals (EDCs) exposure, the common environmental pollutants, was capable of involving in adverse pregnancy outcomes. However, evidence their connection is not consistent. Our goal to comprehensively explore risk EDCs related One hundred and one studies were included from two databases before 2023 association between outcomes including miscarriage, small for gestational age (SGA), low birth weight (LBW) preterm (PTB). We found that maternal PFASs exposure positively correlated with PTB (OR:1.13, 95% CI:1.04–1.23), SGA (OR:1.10, CI:1.04–1.16) miscarriage (OR:1.09, CI:1.00–1.19). The pooled estimates also showed PAEs linked (OR:1.16, CI:1.11–1.21), (OR:1.20, CI:1.07–1.35) (OR:1.55, CI:1.33–1.81). In addition, some specific class PFOS, MBP, MEHP, DEHP, BPA associated PTB. PFOA, PFHpA SGA. LBW. MMP, MEHHP, MEOHP, miscarriage. PFASs, may increase according our study. limited number on dose-response hampered further explanation causal association.

Language: Английский

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Association between PFAS exposure and metabolic-related biomarkers in Spanish adolescents

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121171 - 121171

Published: Feb. 1, 2025

Language: Английский

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Global research trends on the human exposome: a bibliometric analysis (2005–2024)

Environmental Science and Pollution Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 8, 2025

Abstract Exposome represents one of the most pressing issues in environmental science research field. However, a comprehensive summary worldwide human exposome is lacking. We aimed to explore bibliometric characteristics scientific publications on exposome. A analysis from 2005 December 2024 was conducted using Web Science accordance with PRISMA guidelines. Trends/hotspots were investigated keyword frequency, co-occurrence, and thematic map. Sex disparities terms citations examined. From 2024, 931 published 363 journals written by 4529 authors 72 countries. The number tripled during last 5 years. Publications females (51% as first 34% authors) cited fewer times (13,674) than males (22,361). Human studies mainly focused air pollution, metabolomics, chemicals (e.g., per- polyfluoroalkyl substances (PFAS), endocrine-disrupting chemicals, pesticides), early-life exposure, biomarkers, microbiome, omics, cancer, reproductive disorders. Social built environment factors, occupational multi-exposure, digital exposure screen use), climate change, late-life received less attention. Our results uncovered high-impact countries, institutions, journals, references, authors, key trends/hotspots. use technologies sensors, wearables) data artificial intelligence) has blossomed overcome challenges could provide valuable knowledge toward precision prevention. risk scores represent promising avenue.

Language: Английский

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Exposure to Per‐ and Polyfluoroalkyl Substances and the Risk of Prostate and Ovarian Cancer: An Epidemiologic Meta‐Analysis

American Journal of Industrial Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants. Previous research has linked PFAS exposure to prostate ovarian cancer risk, however, the conclusions have been inconsistent. This purpose was determine relationship between at population level. We systematically reviewed three databases-PubMed, Web of Science, Embase-for from when these databases were established April 15, 2024. The quality retrieved evaluated using Newcastle-Ottawa Scale (NOS) measurement tool. Meta-analysis extracted data conducted Stata 18. also sensitivity subgroup analyses, as well Begg's Egger's tests. Twelve publications involved in analysis for cancer, six included ovary cancer. outcomes indicated that PFOS positively related (OR: 1.13, 95% CI: 1.00-1.28), while mixed 1.63, 1.49-1.78). source heterogeneity identified primarily attributable variations study design. No significant bias detected analysis. demonstrated an association both cancers. Further investigation is required clarify underlying mechanisms potential associations.

Language: Английский

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Systematic review and meta-analysis of epidemiologic data on infectious disease in relation to exposure to twelve perfluoroalkyl substances (PFAS)

International Journal of Hygiene and Environmental Health, Journal Year: 2025, Volume and Issue: 266, P. 114571 - 114571

Published: April 5, 2025

While some per- and polyfluoroalkyl substances (PFAS) are immunosuppressants, whether they have an adverse effect on infectious disease morbidity is unclear. We conducted a systematic review meta-analysis of epidemiologic data the association between incremental increase in serum concentration any 12 PFAS risk or rate (ID). From 25 reports representing 18 unique study populations, we meta-analyses stratified exposure type (log-transformed absolute scale) outcome (risk rate). To synthesize that could not be combined with due to different types, additionally vote counting calculated p-values. A small positive ID was more frequently reported than not, though synthesized statistical significance present only few instances. The p-value analyses had many similar findings. In analyses, statistically significant associations were noted Perfluorononanoic acid lower respiratory tract infection (LRTI) event rates, Perfluorooctanesulfonamide LRTI rates combined, Perfluorooctanoic Perfluorodecanoic all Perfluoroundecanoic risk. identified moderate evidence variable size but usually small; certainty was, however, generally low very diminished by possible influences multiple testing covariance among results accounted for analyses. CRD42024551990.

Language: Английский

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