Subchronic Exposure to Polystyrene Microplastic Differently Affects Redox Balance in the Anterior and Posterior Intestine of Sparus aurata DOI Creative Commons
Filomena Del Piano, Adriano Lama,

Anna Monnolo

et al.

Animals, Journal Year: 2023, Volume and Issue: 13(4), P. 606 - 606

Published: Feb. 9, 2023

Microplastics (MPs) are pollutants widely distributed in aquatic ecosystems. MPs introduced mainly by ingestion acting locally or organs far from the gastroenteric tract. MPs-induced health consequences for fish species still need to be fully understood. We aimed investigate effects of subchronic oral exposure polystyrene microplastics (PS-MPs) (1-20 μm) gilthead seabreams (Sparus aurata) used as experimental model. studied detrimental impact PS-MPs (25 and 250 mg/kg b.w./day) on redox balance antioxidant status intestine using histological analysis molecular techniques. The research goal was examine anterior (AI) posterior (PI) tracts, characterized morphological functional differences. caused an increase reactive oxygen nitrosylated proteins both well augmented malondialdehyde production PI. also differently affected gene expression enzymes (i.e., superoxide dismutase, catalase, glutathione reductase). Moreover, increased up-regulation protective heat shock (HSPs) hsp70 hsp90) observed Our findings demonstrate that responsible oxidative/nitrosative stress alterations detoxifying defense system responses with differences AI PI seabreams.

Language: Английский

Microplastics as an Emerging Threat to the Global Environment and Human Health DOI Open Access
Shampa Ghosh, Jitendra Kumar Sinha, Soumya K. Ghosh

et al.

Sustainability, Journal Year: 2023, Volume and Issue: 15(14), P. 10821 - 10821

Published: July 10, 2023

In recent years, there has been mounting concern about the bearing of microplastics on human health and comprehensive natural environment. These particles come from a variety sources, such as soaps, personal care products, rundown bigger plastic items. The impacts marine life other ecosystems are substantial, including ingestion by animals, interference with their reproductive systems, even death. economic implications also significant, industries, fishing tourism being affected presence in Exposure to can pose potential risks humans, respiratory digestive problems, well disrupt sleep, contribute obesity, increase risk diabetes. To address this issue, policies initiatives have put place reduce microplastic pollution, but challenges that need be overcome, lack awareness, limited resources, ineffective regulations. Further research is needed fully understand our develop effective strategies mitigate problem. article, we discussed requirement multifaceted approach reducing use, promoting proper disposal recycling waste, developing innovative technologies for capturing removing environment, raising public implementing regulations policies. It only through concerted efforts collaboration between individuals, governments threat tackled.

Language: Английский

Citations

173
Human Exposure to Microplastics and Its Associated Health Risks DOI Creative Commons
Anqi Sun, Wen‐Xiong Wang

Environment & Health, Journal Year: 2023, Volume and Issue: 1(3), P. 139 - 149

Published: Aug. 2, 2023

Microplastics are a globally emerging contaminant in the environment, but little is known about potential risks of microplastics to human health. Possible exposure routes humans include ingestion, inhalation, and dermal penetration, with last these needing equal attention as other two main routes. Evidence showed presence human-derived biological samples (i.e., excrement, biofluids, tissues). Most toxicological studies on were based laboratory rodents cells. Energy homeostasis, intestinal microflora, reproductive, immune, nervous systems regarded targets microplastics. The toxicity microstructures including lysosomes, mitochondria, endoplasmic reticulum, nucleus further revealed health at cellular levels. As carrier, also had magnify contaminants environment (e.g., plasticizer, metals, antibiotics, microorganisms). Studies environmentally realistic conditions still their infancy many unsolved questions predict

Language: Английский

Citations

90
The Role of Bacterial Polyhydroalkanoate (PHA) in a Sustainable Future: A Review on the Biological Diversity DOI Open Access

Diogo Vicente,

Diogo Neves Proença, Paula V. Morais

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(4), P. 2959 - 2959

Published: Feb. 8, 2023

Environmental challenges related to the mismanagement of plastic waste became even more evident during COVID-19 pandemic. The need for new solutions regarding use plastics came forefront again. Polyhydroxyalkanoates (PHA) have demonstrated their ability replace conventional plastics, especially in packaging. Its biodegradability and biocompatibility makes this material a sustainable solution. cost PHA production some weak physical properties compared synthetic polymers remain as main barriers its implementation industry. scientific community has been trying solve these disadvantages associated with PHA. This review seeks frame role bioplastics substitutes future. It is focused on bacterial PHA, highlighting current limitations process and, consequently, industry, well reviewing alternatives turn into circular economy.

Language: Английский

Citations

69
Microplastics exposure: implications for human fertility, pregnancy and child health DOI Creative Commons

Rewa E. Zurub,

Yusmaris Cariaco, Michael G. Wade

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 4, 2024

Plastics found in our everyday environment are becoming an increasing concern for individual and population-level health, the extent of exposure potential toxic effects these contaminants on numerous human organ systems clear. Microplastics (MPs), tiny plastic particles, appear to have many same biological as their precursors compounded effect accumulation different organs. Recently, microplastic was observed placenta, raising important questions related health pregnancies offspring. These concerns particularly heightened considering developmental origins disease (DOHaD) framework, which postulates that utero can programme lifelong The current review examines state knowledge this topic highlights avenues future investigation.

Language: Английский

Citations

35
A comprehensive review on the source, ingestion route, attachment and toxicity of microplastics/nanoplastics in human systems DOI
Yining Zhu,

Ruijie Che,

Xinyan Zong

et al.

Journal of Environmental Management, Journal Year: 2024, Volume and Issue: 352, P. 120039 - 120039

Published: Jan. 13, 2024

Language: Английский

Citations

31
Polyethylene nanoparticles at environmentally relevant concentrations enhances neurotoxicity and accumulation of 6-PPD quinone in Caenorhabditis elegans DOI

Xin Hua,

Dayong Wang

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 918, P. 170760 - 170760

Published: Feb. 6, 2024

Language: Английский

Citations

28
Toxicological Research on Nano and Microplastics in Environmental Pollution: Current Advances and Future Directions DOI
Saurabh Shukla,

Yang Pei,

Weiguo Li

et al.

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 270, P. 106894 - 106894

Published: March 11, 2024

Language: Английский

Citations

24
Interactions Between Microplastic and Heavy Metals in the Aquatic Environment: Implications for Toxicity and Mitigation Strategies DOI
Nishita Narwal, Mian Adnan Kakakhel,

Deeksha Katyal

et al.

Water Air & Soil Pollution, Journal Year: 2024, Volume and Issue: 235(9)

Published: July 31, 2024

Language: Английский

Citations

23
Important Factors Affecting Induction of Cell Death, Oxidative Stress and DNA Damage by Nano- and Microplastic Particles In Vitro DOI Creative Commons
Kamil Płuciennik, Paulina Sicińska, Weronika Misztal

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(9), P. 768 - 768

Published: April 30, 2024

We have described the influence of selected factors that increase toxicity nanoplastics (NPs) and microplastics (MPs) with regard to cell viability, various types death, reactive oxygen species (ROS) induction, genotoxicity. These include plastic particle size (NPs/MPs), zeta potential, exposure time, concentration, functionalization, environmental type. Studies unequivocally shown smaller particles are more cytotoxic, penetrate cells easily, ROS formation, induce oxidative damage proteins, lipids, DNA. The toxic effects also concentration incubation time. NPs positive potential than those a negative because negatively charged, inducing stronger interactions. deleterious MPs increased by functionalization anionic or carboxyl groups, due greater interaction membrane components. Cationic NPs/MPs particularly their cellular uptake and/or on lysosomal membranes. polystyrene (PS) vary from one type another, normal sensitive cancerous ones. can be enhanced factors, including UV radiation, as they cause shrink change shape, which is important consideration when working environmentally-changed NPs/MPs. In summary, cytotoxicity, properties, genotoxicity depends duration action, Also, diameter exposed functionalized amino demonstrate higher larger, non-functionalized environmentally-unchanged potential.

Language: Английский

Citations

17
Nanoplastic Exposure at Environmental Concentrations Disrupts Hepatic Lipid Metabolism through Oxidative Stress Induction and Endoplasmic Reticulum Homeostasis Perturbation DOI
Weiyu Wang,

Xuan Mao,

Rui Zhang

et al.

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(38), P. 14127 - 14137

Published: Sept. 8, 2023

In this study, we investigated the mechanism underlying perturbation of hepatic lipid metabolism in response to micro/nanoplastic (MP/NP) exposure at environmentally relevant concentrations. Polystyrene (PS) MPs/NPs with different sizes (0.1, 0.5, and 5.0 μm) were studied for their effects on homeostasis function Nile tilapia (Oreochromis niloticus) liver. Results showed that PS readily internalized accumulated various internal organs/tissues, especially fish liver muscle. Smaller-sized NPs caused more severe toxicity than larger MPs, including steatosis, inflammatory response, disturbed function. Mechanistically, a particle size 100 nm perturbed protein endoplasmic reticulum (ER) by inhibiting expression chaperone proteins genes involved ER-associated degradation. This led activation PERK-eIF2α pathway, which dysfunction metabolism. Induction oxidative stress Nrf2/Keap1 pathway also NP-induced accumulation. These findings highlight potential adverse environmental aquatic organisms, raising concerns about ecotoxicity food safety.

Language: Английский

Citations

40