Association of prenatal exposure to perfluorinated and polyfluoroalkyl substances with childhood neurodevelopment: A systematic review and meta-analysis

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 271, P. 115939 - 115939

Published: Jan. 11, 2024

Although previous studies have shown an association between prenatal exposure to perfluorinated and polyfluoroalkyl substances (PFAS) neurodevelopmental disorders in children, the results been inconsistent. We summarize on PFAS neurodevelopment children order better understand relationship. conducted a meta-analysis of developmental outcomes associated with intellectual, executive function behavioral difficulty explore relationship children. searched for articles published up August 3, 2023, included quantified original child Intelligence Quotient (IQ), during pregnancy, systematically summarized that could not be quantified. There is evidence sex-specific children's PIQ. found PFOS [β = −1.56, 95% CI −2.96, − 0.07; per 1 ln (ng/ml) increase], PFOA −1.87, −3.29, 0.46; PFHxS −2.02, −3.23, 0.81; increase] decreased performance IQ boys, but 1.56, 0.06, 3.06; increased girls. are impairments related

Language: Английский

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Effects of Early-life PFAS Exposure on Child Neurodevelopment: A Review of the Evidence and Research gaps

Current Environmental Health Reports, Journal Year: 2025, Volume and Issue: 12(1)

Published: Jan. 31, 2025

Per- and polyfluoroalkyl substances (PFAS) are persistent chemicals with many modern applications, leading to widespread contamination universal human exposure. PFAS exposure during early life is of particular concern, given susceptibility the developing fetal infant brain toxic exposures. This review aims synthesize current evidence, discuss methodological challenges, highlight research gaps guide future studies on impact neurodevelopment. Sixty-one in total were published from 2008 March 2024, 35 last five years. Findings primarily link reduced cognitive, motor, language development infancy increased behavioral issues like hyperactivity childhood. Large have shown mixed results concerning child cognition, executive function, autism, ADHD, some indicating no association or unexpected protective findings. Sex-specific associations been observed, but not consistently. Most has addressed low-level exposure, suggesting subtle potentially significant population-wide neurodevelopmental effects. Recent also highlights concerns about newer, alternative PFAS, they too might affect The effects early-life neurodevelopment merit further study, particularly cumulative prenatal postnatal Research fully explored sensitive subgroups potential mitigating factors such as breastfeeding nutrient intake, which will require larger, more diverse samples. Future directions include deeper study mixtures, interactions other neurotoxic environmental chemicals, newer types. There a need focus neuropsychological functioning later childhood, using direct assessments for reliable evaluations.

Language: Английский

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Poly- and per-fluoroalkyl substances toxicity on skeletal and cognitive well-being: a comprehensive review

Journal of Environmental Science and Health Part C, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 25

Published: Feb. 20, 2025

Poly- and per-fluoroalkyl substances (PFAS) are a large group of synthetic compounds having wide array use in consumer products industries, such as fire suppressant foam, nonstick cookware, paper, water-proof textiles, surfactants, aeronautics, cosmetics. This widespread distribution PFAS, their capacity to accumulate living organisms, harmful effects represent rising concern for public health. A multitude studies have presented information on exposure PFAS broad spectrum adverse health outcomes through animal models observational studies. Here, we reviewed various that related toxicity bone brain its underlying mechanisms. well-established toxicological bone, reduced osteoblastic increased osteoclastic activity, activation peroxisome proliferator activated receptor-γ (PPAR-γ), expression WNT11. With respect brain, been linked with autism, somnolence, sleep disturbances, glioma, Alzheimer's, decreased cognition, Glycogen Synthase β (GSK3β). Further research is required several areas, age-specific impact other beyond perfluorooctane sulfonate (PFOS) perfluorooctanoic acid (PFOA), involvement proliferator-activated receptors PFAS-induced toxicity. Regarding toxicity, extensive adults there currently relative scarcity this age when compared the available conducted children older individuals.

Language: Английский

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Per- and poly-fluoroalkyl substances (PFAS) in circulation in a Canadian population: their association with serum-liver enzyme biomarkers and piloting a novel method to reduce serum-PFAS

Environmental Health, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 15, 2025

Extensive use of per- and polyfluoroalkyl substances (PFAS) has resulted in their ubiquitous presence human blood. PFAS exposures have been associated with multiple adverse health effects. Biomonitoring studies focused on long-chain PFASs, but these are being replaced by short-chain PFASs or alternate chemistries (or replacement such as GenX), resulting changes time. Here, we take advantage serum samples collected part a clinical trial testing the efficacy dietary fiber intervention to reduce cholesterol investigate exposure Canadian participants. Serum were from 72 participants (adult males elevated cholesterol) 2019–2020 at baseline after 4 weeks analyzed for 17 PFASs. The highest geometric mean concentrations measured corresponded PFOSA (7.1 ng/ml), PFOS (4.2, PFOA (1.8 ng/ml) PFHxS (1.3 ng/ml). Four (PFOA, PFOS, PFHxS) two (PFBA, PFHxA) detected 100% GenX was 71% Analyses associations between serum-PFAS biomarkers outcomes showed PFBA, PFHxA, PFDA higher gamma-glutamyl transferase not measures serum-total low-density lipoprotein cholesterol. Comparison 4-week follow-up that total decreased both control groups. However, suite concern identified United States National Academies Sciences, Engineering, Medicine, significantly only group. This observation suggests sustained may body burden, future need sources extend supplement intake beyond weeks. Overall, results show chemistry common this population.

Language: Английский

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Prenatal and perinatal exposure to Per- and polyfluoroalkyl substances (PFAS)-contaminated drinking water impacts offspring neurobehavior and development

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 917, P. 170459 - 170459

Published: Jan. 28, 2024

Language: Английский

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Adverse outcome pathway for the neurotoxicity of per- and polyfluoroalkyl substances: A systematic review

Eco-Environment & Health, Journal Year: 2024, Volume and Issue: 3(4), P. 476 - 493

Published: Aug. 30, 2024

Per- and polyfluoroalkyl substances (PFAS) are endocrine disruptors with unambiguous neurotoxic effects. However, due to variability in experimental models, population characteristics, molecular endpoints, the elucidation of mechanisms underlying PFAS-induced neurotoxicity remains incomplete. In this review, we utilized adverse outcome pathway (AOP) framework, a comprehensive tool for evaluating toxicity across multiple biological levels (molecular, cellular, tissue organ, individual, population), elucidate induced by PFAS. Based on 271 studies, reactive oxygen species (ROS) generation emerged as initiating event 1 (MIE1). Subsequent key events (KEs) at cellular level include oxidative stress, neuroinflammation, apoptosis, altered Ca

Language: Английский

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Using machine learning to investigate the influence of the prenatal chemical exposome on neurodevelopment of young children

NeuroToxicology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Research investigating the prenatal chemical exposome and child neurodevelopment has typically focused on a limited number of exposures controlled for sociodemographic factors maternal mental health. Emerging machine learning approaches may facilitate more comprehensive examinations contributions both health variables to simultaneously. A pipeline that utilized feature selection ranking was applied investigate which common best predict neurodevelopmental outcomes in young children. Data from 407 maternal-child pairs enrolled APrON study were used. Maternal concentrations 32 environmental (i.e., phthalates, bisphenols, per- polyfluoroalkyl substances (PFAS), metals, trace elements) measured during pregnancy 11 factors, as well measures urinary creatinine entered into pipeline. The pipeline, consisted RReliefF variable algorithm support vector regression model, used identify rank subset predictive cognitive, language, motor development Bayley Scales Infant Development- Third Edition (Bayley-III) at 2 years age. Bayley-III cognitive scores predicted using 29 variables, resulting correlation coefficient r=0.27 (R2=0.07). For language outcomes, 45 led result (r=0.30; R2=0.09), whereas 33 (r=0.28, R2=0.09). Environmental chemicals, found be highly ranked predictors Our findings demonstrate potential determine relative importance different outcomes. Future developmental neurotoxicology research should consider sample characteristics such important neurodevelopment.

Language: Английский

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Identification and quantification of bipyridyl dicarboxylic acid isomers by ion mobility spectrometry

Journal of Chromatography A, Journal Year: 2024, Volume and Issue: 1715, P. 464630 - 464630

Published: Jan. 1, 2024

Language: Английский

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Per- and Poly-fluoroalkyl Substances (PFAS) in Circulation in a Canadian Population: Their Association with Serum Liver Enzyme Biomarkers and Piloting a Novel Method to Reduce Serum PFAS

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 3, 2024

Abstract Extensive use of per- and polyfluoroalkyl substances (PFAS) has resulted in their ubiquitous presence human blood. PFAS exposures have been associated with multiple adverse health effects including increased risk liver damage, elevated serum lipids, impaired vaccine response, birth outcomes cancer. Biomonitoring studies focused on measuring long-chain PFAS, but these are being replaced by shorter chain alternative structures, resulting incomplete understanding exposures. Here, we take advantage samples collected as part a clinical trial testing the efficacy dietary fiber intervention to reduce cholesterol investigate exposure legacy replacement chemicals Canadian participants. Serum were from 72 participants 2019-2020 at baseline after 4 weeks analyzed for 17 species. The highest geometric mean concentrations measured corresponded PFOSA (7.1 ng/ml), PFOS (4.2, PFOA (1.8 ng/ml) PFHxS (1.3 ng/ml). Short PFBuA, and/or PFHpA detected 100% GenX was 70% Analyses associations between biomarkers showed PFHxA, PFDA higher gamma-glutamyl transferase not measures total or low-density lipoprotein cholesterol. Comparison 4-week follow-up that decreased both control groups. However, suite concern identified United States National Academies Sciences, Engineering, Medicine, significantly only group. This observation suggests may body burden, future need sources extend beyond weeks. Overall, results show short-chain common this population.

Language: Английский

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Effect of per- and polyfluoroalkyl substances on neurodevelopment: Evidence-based risk assessment in the TRAEC strategy context

Environment International, Journal Year: 2024, Volume and Issue: unknown, P. 109003 - 109003

Published: Sept. 1, 2024

Although emerging evidence on the association between per- and polyfluoroalkyl substances (PFASs) neurodevelopment have been investigated, there is no consensus effect of maternal PFASs in offspring. Here, we assessed risk exposure offspring using a novel Targeted Risk Assessment Environmental Chemicals (TRAEC) strategy based multiple evidence. The from five online databases were analyzed neurodevelopment. potential was evaluated by TRAEC strategy, which conducted comprehensive scoring system with reliability, correlation, outcome fitness integrity. studies additional researchers' experiments included present study to proceed following assessment. Based framework evaluation health risks classified as low (absolute value 0-4), medium 4-8), high 8-10). In study, medium-risk level 5.61 overall risk-score. population-attributable (PAR) 8.26 % for exposure. identified low-risk prenatal ASD behavioral disabilities. chain length, type neurodevelopmental trajectories contributed Consistent results four criteria-based tools (ToxRTool, SciRAP, OHAT IRIS), assessment demonstrated robustness reliability study. These illustrated disorders addition, provided scientific structured method disorders, promoting consistency validation

Language: Английский

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