The Science of The Total Environment,
Journal Year:
2024,
Volume and Issue:
957, P. 177489 - 177489
Published: Nov. 13, 2024
Mercury
pollution,
including
from
its
use
during
gold
mining
and
refining,
remains
an
important
problem
worldwide.
In
particular,
methylmercury,
a
microbial
alteration
of
mercury
released
into
the
environment,
is
major
environmental
neurotoxicant.
Although
there
has
been
growing
concern
about
health
hazards
exposure
to
low
levels
mercury,
effects
prenatal
on
neurodevelopmental
outcomes
in
children
have
remained
controversial.
Japan
Environment
Children's
Study,
large-scale
nationwide
birth
cohort
study,
we
measured
methylmercury
inorganic
concentrations
cord
blood
conducted
developmental
scoring
tests
at
ages
2
4
years.
We
then
analyzed
associations
between
outcomes.
Measurements
obtained
3822
participants
revealed
median
values
7.39
ng/ml
(5th
percentile:
2.95,
95th
18.1)
0.25
0.10,
0.58)
for
respectively.
Analyzing
association
with
fish
consumption,
bonito-tuna
was
most
strongly
correlated
both
blood.
scores
subsequently
examined
3083
individuals,
found
no
significant
either
or
mercury.
Further
quartile
group
analysis
based
concentration-dependent
neurodevelopment
children.
However,
various
factors
influence
neurodevelopment,
long-term
observational
studies
that
consider
those
covariates
are
necessary
more
definitive
conclusion.
findings
our
study
provide
insights
further
research
needed
make
recommendations
safe
intake
thresholds
pregnancy.
Environmental Research,
Journal Year:
2024,
Volume and Issue:
267, P. 120638 - 120638
Published: Dec. 15, 2024
Maternal
exposure
to
per-
and
polyfluoroalkyl
substances
(PFAS)
has
been
linked
child
neurodevelopmental
difficulties.
Neuroimaging
research
these
difficulties
white
matter
microstructure
alterations,
but
the
effects
of
PFAS
on
children's
remains
unclear.
We
investigated
associations
between
maternal
blood
concentrations
six
common
perfluoroalkyl
sulfonates
alterations
in
young
children
using
longitudinal
neuroimaging
data.
This
study
included
84
maternal-child
pairs
from
a
Canadian
pregnancy
cohort.
second
trimester
perfluorohexanesulfonate
(PFHxS)
five
perfluorooctane
sulfonate
(PFOS)
isomers
were
quantified.
Children
underwent
magnetic
resonance
imaging
scans
ages
two
(279
total).
Adjusted
linear
mixed
models
each
fractional
anisotropy
(FA)
mean
diffusivity
(MD).
Higher
associated
with
higher
MD
lower
FA
body
splenium
corpus
callosum
children.
Multiple
sex-specific
found.
In
males,
PFHxS
was
negatively
superior
fasciculus,
while
PFOS
positively
inferior
fasciculus
(ILF).
females,
pyramidal
fibers
fornix,
ILF.
may
alter
development
children,
potentially
contributing
Larger
studies
are
needed
replicate
findings
examine
neurotoxicity
chemicals.
Journal of Xenobiotics,
Journal Year:
2024,
Volume and Issue:
14(4), P. 1771 - 1783
Published: Nov. 12, 2024
Perfluorooctane
sulfonate
(PFOS)
and
perfluorooctanoic
acid
(PFOA)
are
persistent
environmental
pollutants,
raising
concerns
due
to
their
widespread
presence
disruptive
biological
effects.
These
compounds
highly
stable,
allowing
them
bioaccumulate
in
the
environment
living
organisms,
potentially
impacting
critical
physiological
functions
such
as
hormonal
balance,
immune
response,
increasing
cancer
risk.
Despite
regulatory
restrictions,
pervasive
nature
necessitates
further
research
into
potential
effects
on
cellular
neuronal
function.
This
study
first
evaluated
cytotoxic
of
PFOS
PFOA
S1
neuroblastoma
cells;
a
dose-dependent
reduction
cell
viability
was
revealed
for
PFOS,
while
exhibited
minimal
toxicity
until
millimolar
concentrations.
We
investigated
modulate
GABAergic
neurotransmission
using
patch-clamp
electrophysiology.
Both
caused
significant
but
reversible
GABA
receptor-mediated
currents
following
one-minute
pre-treatment.
findings
suggest
that
can
interfere
with
both
signaling,
providing
insights
functional
impacts
highlighting
need
investigation
long-term
consequences
PFAS
exposure
nervous
system
health.
The Science of The Total Environment,
Journal Year:
2024,
Volume and Issue:
957, P. 177489 - 177489
Published: Nov. 13, 2024
Mercury
pollution,
including
from
its
use
during
gold
mining
and
refining,
remains
an
important
problem
worldwide.
In
particular,
methylmercury,
a
microbial
alteration
of
mercury
released
into
the
environment,
is
major
environmental
neurotoxicant.
Although
there
has
been
growing
concern
about
health
hazards
exposure
to
low
levels
mercury,
effects
prenatal
on
neurodevelopmental
outcomes
in
children
have
remained
controversial.
Japan
Environment
Children's
Study,
large-scale
nationwide
birth
cohort
study,
we
measured
methylmercury
inorganic
concentrations
cord
blood
conducted
developmental
scoring
tests
at
ages
2
4
years.
We
then
analyzed
associations
between
outcomes.
Measurements
obtained
3822
participants
revealed
median
values
7.39
ng/ml
(5th
percentile:
2.95,
95th
18.1)
0.25
0.10,
0.58)
for
respectively.
Analyzing
association
with
fish
consumption,
bonito-tuna
was
most
strongly
correlated
both
blood.
scores
subsequently
examined
3083
individuals,
found
no
significant
either
or
mercury.
Further
quartile
group
analysis
based
concentration-dependent
neurodevelopment
children.
However,
various
factors
influence
neurodevelopment,
long-term
observational
studies
that
consider
those
covariates
are
necessary
more
definitive
conclusion.
findings
our
study
provide
insights
further
research
needed
make
recommendations
safe
intake
thresholds
pregnancy.
