Proceedings of the National Academy of Sciences,
Journal Year:
2024,
Volume and Issue:
121(52)
Published: Dec. 16, 2024
More
than
16,000
chemicals
are
incorporated
into
plastics
to
impart
properties
such
as
color,
flexibility,
and
durability.
These
may
leach
from
plastics,
resulting
in
widespread
human
exposure
during
everyday
use.
Two
plastic-associated
chemicals—bisphenol
A
(BPA)
di(2-ethylhexyl)
phthalate
(DEHP)—and
a
class
of
chemicals—brominated
flame
retardants
[polybrominated
diphenyl
ethers
(PBDEs)]—are
credibly
linked
adverse
health
cognitive
impacts.
BPA
exposures
associated
with
ischemic
heart
disease
(IHD)
stroke,
DEHP
increased
all-cause
mortality
among
persons
55
64
y
old,
prenatal
PBDE
mothers
IQ
losses
their
children.
We
estimate
BPA,
DEHP,
38
countries
containing
one-third
the
world’s
population.
find
that
2015,
5.4
million
cases
IHD
346,000
stroke
were
exposure;
approximately
164,000
deaths
55-to-64
olds;
11.7
points
lost
due
maternal
exposure.
costs
these
impacts
be
$1.5
trillion
2015
purchasing
power
parity
dollars.
If
United
States
had
been
at
levels
since
2003,
515,000
fewer
would
have
attributed
between
2003
2015.
2005,
over
42
saved
2005
Toxics,
Journal Year:
2024,
Volume and Issue:
12(3), P. 214 - 214
Published: March 14, 2024
Phthalic
acid
esters
(PAEs),
commonly
used
as
plasticizers,
are
pervasive
in
the
environment,
leading
to
widespread
human
exposure.
The
association
between
phthalate
exposure
and
metabolic
disorders
has
been
increasingly
recognized,
yet
precise
biological
mechanisms
not
well-defined.
In
this
study,
we
explored
effects
of
monoethylhexyl
(MEHP)
monocyclohexyl
(MCHP)
on
glucose
lipid
metabolism
hepatocytes
adipocytes.
hepatocytes,
MEHP
MCHP
were
observed
enhance
uptake
accumulation
a
dose-responsive
manner,
along
with
upregulating
genes
involved
biosynthesis.
Transcriptomic
analysis
indicated
broader
impact
hepatic
gene
expression
relative
MCHP,
but
particularly
promoted
gluconeogenesis
key
enzymes
G6PC
FBP1.
adipocytes,
both
increased
droplet
formation,
mimicking
Peroxisome
proliferator-activated
receptor
γ
(PPARγ)
agonist
rosiglitazone
(Rosi).
revealed
that
predominantly
altered
fatty
pathways
mature
adipocytes
(MA),
whereas
exhibited
less
impact.
Metabolic
perturbations
from
demonstrate
shared
activation
PPARs
pathway
cell-type
discrepancy
might
be
attributed
differential
PPARγ.
Our
results
indicate
disrupt
homeostasis
liver
adipose
through
involve
PPAR
adenosine
monophosphate-activated
protein
kinase
(AMPK)
signaling
pathways,
highlighting
nuanced
cellular
responses
these
environmental
contaminants.
Ecotoxicology and Environmental Safety,
Journal Year:
2025,
Volume and Issue:
289, P. 117670 - 117670
Published: Jan. 1, 2025
Population
exposure
to
plastics
is
increasing,
and
plasticizers
are
frequently
detected
in
humans
as
important
ingredients
of
plastic
products.
However,
patterns
harmful
their
effects
on
neurofilament
light
chain
(NFL),
a
marker
active
brain
pathology,
currently
inconclusive.
Herein,
we
employed
range
statistical
methods
thoroughly
investigate
the
impact
24
hazardous
varying
NFL
concentrations
blood
general
population
533
participants.
Generalized
linear
model
revealed
positive
correlation
between
Mono-isononyl
phthalate
Mono
(2-Ethyl-
5-Hydroxyhexyl)
Phthalate
(MEHHP)
with
NFL.
Furthermore,
significant
dose-response
relationship
was
observed
MEHHP
NFL,
while
Butyl
paraben
(Hydroxy-Isononyl)
Ester
exhibited
distinct
"inverted
U-shaped"
nonlinear
pattern
Additionally,
Weighted
Quantile
Sum
allowed
us
identify
mixed
all
ingredients,
Mono(2-Ethyl-5-Oxohexyl)
Phthalate,
Mono-isobutyl
phthalate,
Mon
butyl
Propyl
Triclosan
occupying
prominent
positions.
Finally,
latent
profile
analysis
categorized
exposures
into
high,
medium,
low
patterns,
confirming
that
higher
posed
risk
factor
for
elevated
levels
blood.
Exposure
significantly
increases
present
contributes
early
detection
intervention
reduce
incidence
neurodevelopmental
disorder.
Environment International,
Journal Year:
2025,
Volume and Issue:
unknown, P. 109421 - 109421
Published: March 1, 2025
The
environmental
fragmentation
of
plastics
generates
a
mixture
plastic
particles
various
sizes,
which
frequently
co-occur
with
other
mobile
and
persistent
pollutants.
Despite
the
prevalence
such
scenarios,
interaction
between
micro-
nanoplastics
(MNPs)
their
combined
effects
pollutants,
as
highly
toxic
hexavalent
chromium
(Cr(VI)),
remain
almost
entirely
unexplored
in
mammalian
species.
This
study
demonstrated
that
nanoplastic
microplastic
co-aggregate
together
influence
Cr
bioaccumulation
patterns
related
physiological
alterations
rats.
Following
four-week
repeated
intragastric
exposure
Wistar
rats
to
MNPs
Cr(VI),
either
alone
or
combination,
significantly
enhanced
liver,
heart,
brain,
skin.
Under
co-exposure
conditions,
Cr(VI)
was
primary
driver
cellular
observed
blood,
including
shifts
immune
cell
subpopulations
(e.g.,
neutrophils,
lymphocytes)
red
blood
indices,
while
serum
biochemistry
reflected
limited
stress.
per
se
decreased
creatine
kinase
activity
increased
cholesterol
levels.
In
summary,
polystyrene
increase
distribution
bioavailability,
but
does
not
uniformly
exacerbate
toxicity.
Instead,
may
selectively
alter
responses,
emphasizing
need
for
deeper
understanding
potential
health
risks.
