Bisphenol S impairs mitochondrial function by targeting Myo19/oxidative phosphorylation pathway contributing to axonal and dendritic injury

Environment International, Journal Year: 2024, Volume and Issue: 186, P. 108643 - 108643

Published: April 1, 2024

Exposure to bisphenol S (BPS) is known adversely affect neuronal development. As pivotal components of polarization, axons and dendrites are indispensable structures within neurons, crucial for the maintenance nervous system function. Here, we investigated impact BPS exposure on axonal dendritic development both in vivo vitro. Our results revealed that during pregnancy lactation led a reduction complexity, density, length prefrontal cortex (PFC) offspring. Employing RNA sequencing technology elucidate underlying mechanisms damage induced by BPS, Kyoto Encyclopedia Genes Genomes (KEGG) analysis highlighted significant alteration oxidative phosphorylation (OXPHOS) pathway, essential mitochondrial Subsequent experiments demonstrate BPS-induced impairment function, including damaged morphology, decreased adenosine triphosphate (ATP) superoxide dismutase (SOD) levels, increased reactive oxygen species malondialdehyde (MDA). These alterations coincided with downregulated expression OXPHOS pathway-related genes (ATP6V1B1, ATP5K, NDUFC1, NDUFC2, NDUFA3, COX6B1) Myosin 19 (Myo19). Notably, Myo19 overexpression restored dysfunction alleviating inhibition pathway. Consequently, this amelioration was associated injury observed cultured neurons PFC.

Language: Английский

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Early-Life Exposure to 4-Hydroxy-4′-Isopropoxydiphenylsulfone Induces Behavioral Deficits Associated with Autism Spectrum Disorders in Mice

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(36), P. 15984 - 15996

Published: Aug. 28, 2024

Exposure to bisphenol A (BPA) during gestation and lactation is considered be a potential risk factor for autism spectrum disorder (ASD) in both humans animals. As novel alternative BPA, 4-hydroxy-4′-isopropoxydiphenylsulfone (BPSIP) frequently detected breast milk placental barrier systems, suggesting transmission from the mother offspring increased of exposure. Gestation are critical periods central nervous system development, which vulnerable certain environmental pollutants. Herein, we investigated behavioral impacts neurobiological effects early-life exposure BPSIP (0.02, 0.1, 0.5 mg/kg body weight/day) mice offspring. Behavioral studies indicated that induced ASD-like behaviors, including elevated anxiety-related behavior decreased spatial memory, male female pups. distinct pattern reduced social novelty was observed only offspring, accompanied by significant alterations antioxidant levels. Transcriptome analysis demonstrated differentially expressed genes (DEGs) were mainly enriched pathways related behaviors neurodevelopment, consistent with phenotype. Besides, decrease protein levels complex IV (COX IV) across all tested populations suggests profound impact on mitochondrial function, potentially leading abnormal energy metabolism individuals autism. Additionally, changes synaptic proteins, evidenced synapsin 1 (SYN1) postsynaptic density protein-95 (PSD95) cerebellum hippocampus, support notion involvement. These findings suggest may induce sex-specific neurotoxic involve oxidative stress, generation, plasticity.

Language: Английский

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Sex-specific impacts of prenatal bisphenol A exposure on genes associated with cortical development, social behaviors, and autism in the offspring’s prefrontal cortex

Biology of Sex Differences, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 15, 2024

Abstract Background Recent studies have shown that prenatal BPA exposure altered the transcriptome profiles of autism-related genes in offspring’s hippocampus, disrupting hippocampal neuritogenesis and causing male-specific deficits learning. However, sex differences effects on developing prefrontal cortex, which is another brain region highly implicated autism spectrum disorder (ASD), not been investigated. Methods We obtained data from RNA sequencing analysis cortex male female rat pups prenatally exposed to or control reanalyzed. BPA-responsive associated with cortical development social behaviors were selected for confirmation by qRT-PCR analysis. Neuritogenesis primary cells was examined. The assessed using two-trial three-chamber tests. impact downregulation a gene (i.e., Sema5a ) vivo interrogated siRNA-mediated knockdown an utero electroporation technique. Results Genes disrupted ASD showed sex-specific dysregulation. Slc9a9 , involved behaviors, downregulated only males, while Anxa2 Junb also linked suppressed females. increased males strong inverse correlation expression levels, whereas, females, decreased correlated levels. impaired utero. Consistent downregulations, novelty observed offspring but males. Conclusion This first study show dysregulated ASD-related functions, including sex-dependent manner. Our findings suggest that, besides could exert its adverse through molecular mechanisms turn would lead neuropathology clinical manifestations, deserves further investigation.

Language: Английский

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Implications of Prenatal Exposure to Endocrine-Disrupting Chemicals in Offspring Development: A Narrative Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1556 - 1556

Published: May 21, 2024

During the last decades, endocrine-disrupting chemicals (EDCs) have attracted attention of scientific community, as a result deepened understanding their effects on human health. These compounds, which can reach populations through food chain and number daily life products, are known to modify activity endocrine system. Regarding vulnerable groups like pregnant mothers, potential damage they cause increases importance, since it is health two lives that at risk. EDCs affect gestation process, altering fetal development, eventually inducing appearance many disorders in childhood and/or adulthood. Because this, several these substances been studied clarify influence prenatal exposure cognitive psychomotor development newborn, together with non-communicable diseases other disorders. The most novel research subject has gathered this narrative review, aim clarifying current knowledge subject. shown, different studies involving both animal investigation, detrimental effect children exposed during pregnancy, sometimes sex-specific outcomes. However, some failed find associations, highlights need for deeper more rigorous research, will provide an even solid foundation establishment policies against extended use chemicals.

Language: Английский

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Nonylphenol exposure increases the risk of Hirschsprung’s disease by inducing macrophage M1 polarization

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 290, P. 117756 - 117756

Published: Jan. 1, 2025

Language: Английский

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Integrating scRNA-seq to explore offspring neurodevelopmental toxicity induced by Cyfluthrin exposure during pregnancy: a fate decision for NSCs

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138205 - 138205

Published: April 1, 2025

Cyfluthrin is a widely used insecticide, and studies have shown that its exposure during pregnancy associated with neurobehavioral abnormalities in offspring, but the mechanism of toxicity unknown. In this study, we observed neurodevelopmental rat offspring different ages due to exposure, which manifested series impairments such as persistent cognitive impairment, neuronal loss hippocampal tissues, synaptic damage, altered expression neurodevelopmental-related factors. Hippocampal scRNA-seq neonatal rats showed specific cellular responses prenatal exposure. Through DEG intergroup difference analysis, intercellular communication mimetic timing found change fate neural stem cells - alterations differentiation direction, proliferation, apoptosis levels was main cause offspring's developmental induced by This inference verified our vivo ex experiments. Our study first constructed single cell atlas brain hippocampus exposed pregnancy. It warns about pesticide intake nursing women provides theoretical basis for from early life environmental pollutants.

Language: Английский

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Prenatal Environmental Antibiotic Exposure and Autism Spectrum Disorder Symptoms in Children at 3 Years of Age: Findings from the Ma’anshan Birth Cohort Study

Environment & Health, Journal Year: 2024, Volume and Issue: 2(9), P. 651 - 660

Published: June 14, 2024

Antibiotic exposure during pregnancy may affect the neurodevelopment of children, but biomonitoring-based population studies on this class new pollutants are lacking. We conducted a prospective birth cohort study 2860 mother–child pairs, measured urinary concentrations 41 antibiotics and their two metabolites over three trimesters, assessed children's autism spectrum disorder (ASD) symptoms at 3 years age. examined associations between prenatal antibiotic ASD symptoms. The least absolute shrinkage selection operator regression screened for Tetracycline Ofloxacin as important predictors Modified Poisson models revealed that maternal throughout increased risk (RR: 1.66, 95% CI: 1.14, 2.40). Maternal first 1.74, 1.13, 2.68) third trimesters 1.86, 1.16, 3.00) in boys, trimester 1.47, 1.07, 2.02) girls. No dose-dependent relationships were validated by restricted cubic splines. Prenatal to increase might be key windows.

Language: Английский

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Effects of maternal nonylphenol exposure on the proliferation of glial cells in the brain of male offspring mice

Animal Cells and Systems, Journal Year: 2024, Volume and Issue: 28(1), P. 439 - 452

Published: Sept. 12, 2024

Glial cells play a significant role in maintaining brain homeostasis and normal development, their functions can be impaired by exposure to endocrine disruptors. 4-n-Nonylphenol (NP), representative disruptor, is widely used personal care products industrial materials. NP accumulates various organs, including the brain, of living organisms adversely influences health. However, studies on effects glial are limited. This study aims investigate using primary mixed offspring mice exposed during gestation lactation.

Language: Английский

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Mitigating effect of Bifidobacterium longum CCFM1077 on nonylphenol toxicity: An integrative in vitro and in vivo analysis

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136401 - 136401

Published: Nov. 5, 2024

Language: Английский

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Research Progress on the Relationship among Anxiety, Depression, Sleep Disorders and Inflammatory Bowel Disease from the Microbiome-Gut-Brain Axis

Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(04), P. 862 - 868

Published: Jan. 1, 2024

Language: Английский

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