Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 23, 2025
Abstract
Objectives
The
long-term
relationship
between
prenatal
substance
exposure
(PSE)
and
obesity
development
remains
inconclusive
poorly
understood.
This
study
aimed
to
explore
the
heterogeneity
in
adiposity
developmental
trajectories
from
pre-
early
adolescence
investigate
influence
of
PSE
on
these
patterns.
Methods
Five
waves
data
7
881
children
enrolled
Adolescent
Brain
Cognitive
Development
(ABCD)
Study
(Release
5.1)
were
analyzed.
Tri-Ponderal
Mass
Index
(TMI)
was
used
assess
levels.
(e.g.,
tobacco,
alcohol,
caffeine,
marijuana)
collected
via
maternal
self-report.
Latent
growth
mixture
modeling
conducted
identify
TMI
trajectories,
followed
by
multinomial
logistic
regression
examine
role
profiles,
controlling
for
various
factors.
Results
Three
identified:
Stable
TMI
(86.6%),
Increasing
(12.5%),
Decreasing
(0.9%).
risk
exhibiting
an
associated
with
tobacco
(β
=
1.53,
95%
CI
1.26–1.86,
p
<
.001)
caffeine
(daily
use:
β
1.39,
1.16–1.68,
.001;
weekly
1.38,
1.13–1.69,
.05),
dose-dependent
effects.
Notably,
both
before
1.55,
1.27–1.89,
after
awareness
pregnancy
1.51,
1.10–2.08,
.05)
contributed
this
risk,
no
significant
benefit
cessation
awareness.
Multiple
substantially
elevated
increasing
1.70,
1.27–2.27,
.001).
Conclusions
Obesity
can
emerge
long
adolescence,
even
during
development.
findings
regarding
highlight
importance
preconception
health
interventions
mitigate
offspring.
Ecotoxicology and Environmental Safety,
Journal Year:
2025,
Volume and Issue:
290, P. 117773 - 117773
Published: Jan. 1, 2025
Long-term
fine
particulate
matter
(PM2.5)
exposure
was
associated
with
childhood
obesity.
However,
the
key
PM2.5
components
and
whether
effect
may
vary
by
obesity
type,
growth
stage,
sex,
individual/family
characteristics
have
yet
been
examined.
In
this
study,
we
investigated
213,907
Chinese
children
adolescents
aged
3-18
years
in
2017-2019.
Three-year
average
concentrations
of
five
major
were
assigned
to
each
participant's
address.
Multivariable
mixed-effects
model
weighted
quantile
sum
regression
used
estimate
sizes
component.
Stratified
analyses
performed
age
sex
groups,
interactive
effects
a
series
features
evaluated.
The
odds
ratio
1.28
(95
%CI:
1.15-1.43)
for
per
interquartile
range
increase
PM2.5,
organic
identified
as
contributor.
General
central
mixed
more
sensitive
than
peripheral
As
aged,
size
attenuated
general
obesity,
remained
unchanged
increased
Females,
obese
parents,
those
lower
levels
physical
activity
vulnerable
others.
Other
adverse
modifiers
certain
included
family
one
child,
low
income,
less
sleep
duration.
Our
findings
emphasize
that
influence
its
on
risk
should
be
considered
comprehensively
developing
adequate
prevention
strategies.
BMC Public Health,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: March 28, 2025
Prior
research
has
yielded
incongruent
results
about
the
association
between
air
pollutants
and
offspring
hemoglobin
levels,
as
well
child
development.
This
may
be
because
previous
studies
have
not
taken
both
pollution
nutrition
into
account.
study
sought
to
examine
correlations
postnatal
exposure
(PM2.5,
PM10,
SO2,
CO),
stunting,
underweight.
Furthermore,
we
investigated
whether
levels
mediate
these
connections
assessed
moderating
influence
of
dietary
supplementation
on
growth
outcomes.
A
unified
package
intervention
was
conducted
in
western,
China
2016
2023.
In
accordance
with
WHO
guidelines,
underweight,
height-for-age
z
score
(HFA),
weight-for-age
(WFA),
anemia
status
were
all
defined.
daily
average
PM2.5,
CO
collected
from
National
Urban
Air
Quality
Real-Time
Dissemination
Platform
(
http://www.cnemc.cn/sssj/
)
Environmental
Monitoring
General
Station.
Linear
regression
logistic
models
used
assess
correlation
above
indicators.
The
mediating
role
effect
nutritional
also
evaluated.
examined
impact
growth,
mediated
by
moderated
(YingYangBao,
YYB).
Our
findings
suggest
that
negatively
affects
via
reduced
but
extended
mitigates
this
effect.
total
10,766
children
under
5
years
age
participated
study.
All
four
associated
their
effects
development
uniform.
Specifically,
PM2.5
PM10
showed
stronger
negative
associations
HFA
WFA,
while
SO2
had
weaker
effects.
a
greater
outcomes
anemic
compared
non-anemic
children.
Hemoglobin
13.4%
(VAF
=
13.4%,
Cohen's
f²
0.15).
duration
YYB
moderates
HFA.
direct
attenuated
when
use
>
10
months,
whereas
low
group
enhanced
(β=-0.0444,
95%CI:
-0.0613,
-0.03).
Postnatal
CO)
increases
risk
particularly
during
critical
developmental
window
6-23
months
age.
is
partially
can
moderate
relationship.
These
highlight
importance
prolonged
interventions
mitigating
adverse
development,
significant
implications
for
public
health
policies
targeting
quality
high-pollution
regions.
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 26, 2024
Abstract
Objectives
The
long-term
relationship
between
prenatal
substance
exposure
(PSE)
and
obesity
development
remains
inconclusive
poorly
understood.
This
study
aimed
to
explore
the
heterogeneity
in
adiposity
developmental
trajectories
from
pre-
early
adolescence
investigate
influence
of
PSE
on
these
patterns.
Methods
Five
waves
data
7
881
children
enrolled
Adolescent
Brain
Cognitive
Development
(ABCD)
Study
(Release
5.1)
were
analyzed.
Tri-Ponderal
Mass
Index
(TMI)
was
used
assess
levels.
(e.g.,
tobacco,
alcohol,
caffeine,
marijuana)
collected
via
maternal
self-report.
Latent
growth
mixture
modeling
conducted
identify
TMI
trajectories,
followed
by
multinomial
logistic
regression
examine
role
profiles,
controlling
for
various
factors.
Results
Three
identified:
Stable
(86.6%),
Increasing
(12.5%),
Decreasing
(0.9%).
risk
exhibiting
an
associated
with
tobacco
(β
=
1.53,
95%
CI
1.26–1.86,
p
<
.001)
caffeine
(daily
use:
β
1.39,
1.16–1.68,
.001;
weekly
1.38,
1.13–1.69,
.05),
dose-dependent
effects.
Notably,
both
before
1.55,
1.27–1.89,
after
awareness
pregnancy
1.51,
1.10–2.08,
.05)
contributed
this
risk,
no
significant
benefit
cessation
awareness.
Multiple
substantially
elevated
increasing
1.70,
1.27–2.27,
.001).
Conclusions
Obesity
can
emerge
long
adolescence,
even
during
development.
findings
regarding
highlight
importance
preconception
health
interventions
mitigate
offspring.
Children,
Journal Year:
2024,
Volume and Issue:
11(12), P. 1536 - 1536
Published: Dec. 18, 2024
Background:
The
aim
of
this
study
was
to
explore
the
association
between
long-term
exposure
particulate
matter
with
an
aerodynamic
diameter
<2.5
μm
(PM2.5)
and
its
components
severe
obesity
in
children
adolescents.
Methods:
Data
for
adolescents
aged
9–18
cross-sectional
were
obtained
from
2019
Chinese
National
Survey
on
Students’
Constitution
Health
(CNSSCH).
PM2.5
Tracking
Air
Pollution
China
(TAP)
dataset
matched
information
these
children.
Logistic
regression
models
used
assess
risk
associated
components.
Results:
A
total
160,205
included
analysis.
Long-term
may
increase
odds
childhood
obesity,
effect
being
more
pronounced
girls.
Among
boys,
component
most
significant
impact
organic
(OM).
greater
low
economic
parental
education
level
households.
Children
unhealthy
lifestyle
habits
have
higher
due
Conclusions:
findings
research
support
development
strategies
aimed
at
addressing
children,
suggesting
that
adopting
healthy
practices
could
mitigate
There
is
a
need
increased
focus
economically
underdeveloped
areas
those
habits,
particularly
rural
who
do
not
engage
adequate
physical
activity
or
get
enough
sleep.
Children,
Journal Year:
2024,
Volume and Issue:
11(12), P. 1545 - 1545
Published: Dec. 19, 2024
The
present
study
investigated
the
relationship
between
air
pollution,
specifically
PM2.5
and
PM10,
childhood
adolescent
obesity
in
northern
central
Taiwan.
Previous
research
has
shown
a
positive
correlation
pollution
pediatric
obesity,
but
no
been
conducted
We
used
data
from
K-12
Education
Administration,
Ministry
of
Education,
Taiwan
Air
Quality
Monitoring
Network
to
analyze
association
PM10
exposures
rates
among
elementary
junior
high
school
students.
Data
on
students'
height
weight
were
combined
with
obtained
monitoring
stations
assess
exposure.
A
multivariable
model
estimated
relative
risk
95%
confidence
intervals
linked
exposures.
Cities
categorized
into
quartiles
(Q1-Q4)
based
pollutant
accumulation
compare
rates.
Students
living
areas
higher
(Q4)
had
significantly
than
those
lower
(Q1).
effect
was
more
pronounced
girls
older
students,
exhibiting
stronger
PM10.
are
associated
an
increased
children
adolescents,
particularly
Further
is
needed
explore
underlying
mechanisms
control
for
socioeconomic
demographic
factors.
