Mild Gestational Hypothyroidism in Mice Has Transient Developmental Effects and Long-Term Consequences on Neuroendocrine Systems DOI
Clarisse Quignon,

Annika E. Bäcker,

Jessica Kearney

et al.

Thyroid, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Thyroid hormones (TH) play a key role in fetal brain development. While severe thyroid dysfunction, has been shown to cause neurodevelopmental and reproductive disorders, the rising levels of TH-disruptors environment past few decades have increased need assess effects subclinical (mild) TH insufficiency during gestation. Since embryos do not produce their own before mid-gestation, early development processes rely on maternal production. Notably, network governed by gonadotropin-releasing hormone (GnRH) neurons develops this critical period.

Language: Английский

The Chemical Exposome on Ovarian Aging in Adult Women: a Narrative Review DOI
Lauren Petrick, Lauren A. Wise,

Elena Colicino

et al.

Current Pollution Reports, Journal Year: 2025, Volume and Issue: 11(1)

Published: Feb. 19, 2025

Language: Английский

Citations

0
Sex-Specific and Trimester-Specific Associations of Prenatal Exposure to Bisphenols, Parabens, and Triclosan with Neonatal Birth Size and Gestational Age DOI

Jinfeng Fu,

Yao Yao, Zhihong Huang

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(31), P. 13687 - 13696

Published: July 27, 2024

Bisphenols, parabens, and triclosan (TCS) are common endocrine disrupters used in various consumer products. These chemicals have been shown to cross the placental barrier affect intrauterine development of fetuses. In this study, we quantified serum levels six bisphenols, five TCS 483 pregnant women from southern China. Quantile-based g-computation showed that combined exposure was significantly (

Language: Английский

Citations

2
The effect of bisphenols on sex and thyroid hormone concentrations in cord blood among newborns DOI
Francis Manyori Bigambo, Zhaofang Chen, Wentao Yang

et al.

Food and Chemical Toxicology, Journal Year: 2024, Volume and Issue: 189, P. 114750 - 114750

Published: May 20, 2024

Language: Английский

Citations

1
An in-situ versatile screening method for identifying SVOC sources in indoor environments DOI Creative Commons
Yatai Li, Shihao Zhang,

Zichen Guo

et al.

Environment International, Journal Year: 2024, Volume and Issue: 189, P. 108794 - 108794

Published: June 1, 2024

Indoor semivolatile organic compounds (SVOCs) pose a substantial threat to human health. However, identifying the sources of these emissions has been challenging owing scarcity convenient and practical on-site methodologies. Herein, novel method for source screening was proposed using aluminum silicate sampling strips adsorb SVOCs from surface air indoor materials. The adsorbed SVOC levels indicate emission intensity materials into environments. Additionally, compact can be readily fixed any vertical static sticker, facilitating characterization various in settings. Laboratory-simulated experiments demonstrated capability differentiate between non-source within 10-cm distance same space. In scenarios, primary identified via this exhibited consistent correlation with contents corresponding obtained traditional solvent-extraction method. As were directly transferred GC–MS through thermal desorption instead procedure, several-fold improvements analytical sensitivity efficiency. Using versatile technique, some emerging important species specific Eliminating as an effective approach mitigate pollution. Overall, offers powerful tool managing pollutants safeguarding

Language: Английский

Citations

1
Thyroid under Attack: The Adverse Impact of Plasticizers, Pesticides, and PFASs on Thyroid Function DOI Creative Commons
V Rodrigues, Guilherme Henrique,

Érica Kássia Sousa-Vidal

et al.

Endocrines, Journal Year: 2024, Volume and Issue: 5(3), P. 430 - 453

Published: Sept. 19, 2024

Endocrine-disrupting chemicals (EDCs) are synthetic or natural compounds that interfere with the endocrine system, inducing harmful effects on organisms depending dose and period of exposure. Numerous studies have identified concerning amounts EDCs in environmental human samples. The thyroid gland is essential for hormone production controls several body functions. Several been classified as disruptors, impairing production, synthesis, metabolism, transport, and/or actions. Notably, disorders second most prevalent disease worldwide, incidence increasing significantly recent years. Some correlated this rise dysfunctions cancers increased exposure to EDCs. Although many linked dysfunction, review focuses deleterious plasticizers, organochlorine pesticides, per- poly-fluoroalkyl substances function. These contaminants commonly found food, water, everyday products. impact these controversial, numerous epidemiological, vivo, vitro indicated their Given critical role function growth, development, summarizes consequences disruptors health.

Language: Английский

Citations

1
Gestational Exposure to Endocrine-Disrupting Chemicals of Emerging Concern and the Risk of Developing Gestational Diabetes Mellitus: A Comprehensive Investigation of Sex-Specific and Trimester-Specific Associations DOI Creative Commons

Jinfeng Fu,

Yao Yao, Zhihong Huang

et al.

Environment & Health, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

Gestational diabetes mellitus (GDM) is a type of that arises during pregnancy, leading to long-term adverse consequences for maternal health and fetal development. However, the specific role endocrine-disrupting chemicals (EDCs) in pathogenesis GDM remains controversial. This prospective cohort study sought investigate how coexposure bisphenols, parabens, triclosan (TCS), benzophenone-type UV filters, neonicotinoids (NEOs) affects odds GDM. Quantile-based g-computation Bayesian kernel machine regression showed significant inverse relationship between EDC mixtures reduced risk (OR = 0.34, 95% CI: 0.13-0.87), which was mainly explained by bisphenol 0.49, 0.29-0.80) paraben 0.60, 0.40-0.91) exposure. Bisphenol S (BPS), Z (BPZ), ethylparaben (EtP), propylparaben (PrP), butylparaben (BuP) were identified as key contributors joint effect. In addition, subgroup analyses suggested bisphenols-GDM association more pronounced younger/normal-weight participants. The sex-specific impact exposure bisphenols on development observed, whereas second trimester represented critical window Continued research efforts, focusing causal pathways nonmonotonic relationships, will be crucial elucidate complex influence

Language: Английский

Citations

1
Tire-Added Chemicals, Maternal and Neonatal Thyroid Hormones, and Childhood Growth: A Longitudinal Cohort Study DOI
Ruixin Chen, Yin Wang, Rongrong Cheng

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Mild Gestational Hypothyroidism in Mice Has Transient Developmental Effects and Long-Term Consequences on Neuroendocrine Systems DOI
Clarisse Quignon,

Annika E. Bäcker,

Jessica Kearney

et al.

Thyroid, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Thyroid hormones (TH) play a key role in fetal brain development. While severe thyroid dysfunction, has been shown to cause neurodevelopmental and reproductive disorders, the rising levels of TH-disruptors environment past few decades have increased need assess effects subclinical (mild) TH insufficiency during gestation. Since embryos do not produce their own before mid-gestation, early development processes rely on maternal production. Notably, network governed by gonadotropin-releasing hormone (GnRH) neurons develops this critical period.

Language: Английский

Citations

0