Exploring peripheral fluid biomarkers for early detection of Alzheimer’s disease in Down syndrome: A literature review DOI Creative Commons

Charlotte Jacob,

M. De Tollenaere,

Hanane Kachar

et al.

Heliyon, Journal Year: 2024, Volume and Issue: unknown, P. e41445 - e41445

Published: Dec. 1, 2024

People with Down Syndrome (DS) are at high risk of developing Alzheimer's disease dementia (AD) and cerebral amyloid angiopathy, which is a critical factor contributing to in sporadic AD. Predicting monitoring the decline onset diagnostic challenge essence daily care support for people DS. In this literature scoping review, we first summarize different blood-based biomarkers AD Next, describe urine-based DS finally, explore various general population. Apart from classic beta Tau biomarkers, also discuss more out-of-the-box such as neurofilament light chain, Dual-specificity tyrosine-regulated kinase 1A, monoaminergic biomarkers. These potential could be valuable addition established panel fluid

Language: Английский

Fast Detection of Uric Acid in Urine for Early Diagnosis Using THz Polarized Waves DOI Creative Commons
Zahra Mazaheri, Giorgia Federico, Can Koral

et al.

Sensors, Journal Year: 2025, Volume and Issue: 25(4), P. 1004 - 1004

Published: Feb. 8, 2025

Towards new and improved techniques in liquid biopsy for the diagnosis of diseases, this study reports experimental evidence a rapid reliable method based on terahertz (THz) time-domain spectroscopic ellipsometry (TDSE) early kidney-related using detection uric acid (UA) content urine. Employing custom-built THz-TDSE system, we analyzed absorption dispersion response synthetic urine samples with varying concentrations UA. The technique provides prompt indication UA presence concentration, thanks to sensitivity THz waves intermolecular interactions such as hydrogen bonding. results clearly show linear correlation between concentration changes spectra frequency window 0.2–1.2 THz, minimum detectable being approximately close upper limit normal levels increase coefficient function means quantifiable measure biomarker assessing disease stage. This proves that is capable detecting at relevant early-stage renal an estimated 0.2 g/L region where material linear.

Language: Английский

Citations

0
Fluid-based biomarkers for neurodegenerative diseases DOI Creative Commons
Yongliang Cao, Yifei Xu, Meiqun Cao

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102739 - 102739

Published: March 1, 2025

Language: Английский

Citations

0
Epitope-Imprinted Field-Effect Transistors Overcome Debye Length Limitations for Label-Free Protein Detection DOI
Lishuang Wang, Lei Bao,

Liyan Qiao

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Graphene-based field-effect transistor (GFET) biosensors face limitations in detecting charged analytes due to ionic screening (Debye effect). This limitation restricts their ability detect target situ physiological solutions. To overcome this challenge, we present a non-destructive van der Waals (vdW) integration of an epitope molecular-imprinted membrane (EMIM) with GFET biosensor. innovative vdW-heterostructured biosensor, termed the EMIM-Chip, features 3.3 ± 1.7 nm thin EMIM dielectric layer self-assembled on graphene surface. The layer, featuring specifically imprinted cavities, replaces antibodies and effectively mitigates screening. innovation enables rapid detection Alzheimer's disease (AD) biomarker Aβ proteins (50 aM-5 pM) purified samples patient plasma/urine within minutes. Notably, these sensors retain functionality even after 30 days environmental storage, positioning our approach as promising foundation for future medical tool development.

Language: Английский

Citations

0
Fast detection of uric acid in urine for early diagnosis using THz polarised waves DOI Creative Commons
Zahra Mazaheri, Giorgia Federico, Can Koral

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Abstract Towards new and improved techniques in liquid biopsy for diagnosis of diseases, this study reports experimental evidence a rapid reliable method based on terahertz (THz) time-domain spectroscopic ellipsometry (TDSE) early kidney-related by detecting uric acid (UA) urine. By measuring absorption dispersion spectra urine samples, the potential THz-TDSE non-invasive, accurate detection UA as urinary biomarker is investigated. Employing custom-built system, we analysed response synthetic samples with varying concentrations UA. The technique provides prompt indication presence concentration, thanks to sensitivity THz waves intermolecular interaction such hydrogen bonding. results show frequency window 0.2¸1.2 linear correlation between concentration changes urine, minimum detectable being approximately close upper limit normal levels increase coefficient function means quantifiable measure assessing disease stage. confirms that capable at relevant early-stage renal diseases. Moreover, estimate 0.2 g/L region where material linear.

Language: Английский

Citations

0
Immunomonitoring in bladder cancer: a short report on stability of leukocytes and proteins in refrigerated urine samples DOI Creative Commons
Alexandra Sevko,

Claudia Prevosto,

S. Ragavan

et al.

BMC Urology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 21, 2024

Urine biomarkers are crucial for monitoring patient responses in treating urological pathologies, including non-muscle invasive bladder cancer (NMIBC). Yet, analysing urine poses several challenges, ensuring specimen stability during transportation and analytical processing. This prospective feasibility study aimed to investigate how urinary leukocytes proteins impacted by storing refrigerating urine. Stability of from four healthy donors (HD) spiked into supernatants was analyzed up 72 h at 4°C. samples five NMIBC patients undergoing BCG treatment were divided two portions, followed either immediate processing or overnight refrigeration. Urinary cell content soluble factors multiparameter flow cytometry Luminex®, respectively. We confirmed the donor peripheral blood cell-free untreated under refrigeration + 5℃. Additionally, we conducted immune proteomic analysis obtained receiving Bacillus Calmette-Guérin (BCG) therapy processed immediately after successfully demonstrated that leukocyte protein composition remain stable refrigerated BCG-treated 24 h. included granulocytes, monocytes, T cells, as well total protein, creatinine 46 additional individual immune-related mediators. work demonstrates compatibility shipment collection sites laboratories with both immunophenotyping establishes clear logistical benefits numerous clinical settings focused on matrix.

Language: Английский

Citations

0
Exploring peripheral fluid biomarkers for early detection of Alzheimer’s disease in Down syndrome: A literature review DOI Creative Commons

Charlotte Jacob,

M. De Tollenaere,

Hanane Kachar

et al.

Heliyon, Journal Year: 2024, Volume and Issue: unknown, P. e41445 - e41445

Published: Dec. 1, 2024

People with Down Syndrome (DS) are at high risk of developing Alzheimer's disease dementia (AD) and cerebral amyloid angiopathy, which is a critical factor contributing to in sporadic AD. Predicting monitoring the decline onset diagnostic challenge essence daily care support for people DS. In this literature scoping review, we first summarize different blood-based biomarkers AD Next, describe urine-based DS finally, explore various general population. Apart from classic beta Tau biomarkers, also discuss more out-of-the-box such as neurofilament light chain, Dual-specificity tyrosine-regulated kinase 1A, monoaminergic biomarkers. These potential could be valuable addition established panel fluid

Language: Английский

Citations

0