Current Eye Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 9
Published: Dec. 11, 2024
Age-related macular degeneration (AMD) is a chronic retinal disease that can lead to blindness. While the NLR family pyrin domain containing 3 (NLRP3) inflammasome implicated in AMD, specific roles of miR-21 and NLRP3 AMD-related inflammation remain unclear. Therefore, this study aimed investigate blue light-induced neurodegeneration mouse retina.
Language: Английский
Polymers, Journal Year: 2025, Volume and Issue: 17(2), P. 233 - 233
Published: Jan. 17, 2025
Abstract: Quantum dot–polymer composites have the advantages of high luminescent quantum yield (PLQY), narrow emission half-peak full width (FWHM), and tunable spectra, broad application prospects in display lighting fields. Research on dots embedded polymer films plates has made great progress both synthesis technology optical properties. However, due to shortcomings dots, such as cadmium selenide (CdSe), indium phosphide (InP), lead halide perovskite (LHP), poor water, oxygen, light stability, incapacity for large-scale synthesis, their practical is still restricted. Various polymers, methyl methacrylate (PMMA), polyethylene terephthalate (PET), polystyrene (PS), polyvinylidene fluoride (PVDF), polypropylene (PP), etc., are widely used packaging dot materials because plasticity, simple curing, chemical good compatibility with materials. This paper focuses development field backlight displays, summarizes expounds strategies, advantages, disadvantages different materials, provides inspiration optimization promotes wide-color-gamut display.
Language: Английский
Citations
1
Journal of Neuroinflammation, Journal Year: 2024, Volume and Issue: 21(1)
Published: June 24, 2024
Abstract Radiation retinopathy (RR) is a major side effect of ocular tumor treatment by plaque brachytherapy or proton beam therapy. RR manifests as delayed and progressive microvasculopathy, ischemia macular edema, ultimately leading to vision loss, neovascular glaucoma, and, in extreme cases, secondary enucleation. Intravitreal anti-VEGF agents, steroids laser photocoagulation have limited effects on RR. The role retinal inflammation its contribution the microvascular damage occurring remain incompletely understood. To explore cellular vascular events after irradiation, we analyzed their time course at 1 week, month 6 months rat eyes received 45 Gy X-beam photons. Müller glial cells, astrocytes microglia were rapidly activated, these markers persisted for irradiation. This was accompanied early cell death outer retina, which later points, thinning. A loss small capillaries hypoxia observed months, indicating inner blood‒retinal barrier (BRB) alteration but without retina. Moreover, activated microglial cells invaded entire retina surrounded vessels, suggesting death. also triggered persistent invasion pigment epithelium macrophages, contributing BRB disruption. study highlights long-lasting inflammatory mechanisms development demonstrates relevance this model investigate human pathology.
Language: Английский
Citations
5
Investigative Ophthalmology & Visual Science, Journal Year: 2025, Volume and Issue: 66(1), P. 3 - 3
Published: Jan. 2, 2025
Purpose: Because chickens have excellent light perception properties, this study focused on investigating whether monochromatic can cause photodamage in chicken retinal ganglion cells (RGCs). Methods: Post-hatching day were exposed to four different light-emitting diode environments for five weeks, respectively, blue (480 nm), green (560 red (660 or white (6000 K). The mechanisms through which influences the structure of retina analyzed by detecting morphological retina, gene and protein expression levels, ultrastructure optic nerve. Results: Blue exposure weeks significantly impacted thickness inner reticular layer, synaptic function, number RGCs retina. Moreover, neurodegenerative disease characteristics, such as a reduction dendritic branches presence myelin lesions, also been observed RGCs. activation kinase RNA-like ER kinase-mediated unfolded response, along with abnormal degradation autophagy substrate P62, accompanies these pathological processes. Additionally, our findings indicate that photosensitivity OPN4 is linked endoplasmic reticulum stress RGCs, may elucidate why experience damage exclusively under exposure. Conclusions: autophagy, especially Our enhances understanding underlying emphasizes risk low-illuminance environments.
Language: Английский
Citations
0
Journal of Photochemistry and Photobiology B Biology, Journal Year: 2025, Volume and Issue: 264, P. 113118 - 113118
Published: Feb. 1, 2025
Language: Английский
Citations
0
Neurobiology of Sleep and Circadian Rhythms, Journal Year: 2025, Volume and Issue: unknown, P. 100119 - 100119
Published: April 1, 2025
Language: Английский
Citations
0
Optics and Lasers in Engineering, Journal Year: 2024, Volume and Issue: 184, P. 108614 - 108614
Published: Oct. 2, 2024
Language: Английский
Citations
3
Acta Chimica Slovaca, Journal Year: 2024, Volume and Issue: 17(1), P. 55 - 62
Published: Jan. 1, 2024
Abstract As people spend many hours looking at digital screens, the negative effects of artificial blue light are becoming more apparent. While most research has focused on its eyes, less is known about skin, where similar photoreceptors located. Unlike sunscreens against UVB and UVA radiation, there no standard method for determining skin protection light. The lipophilic complex Carotolino, a system combining carrot root extract, seed oil, β-carotene, was chosen as model substance this research. Spectrophotometric investigation demonstrated ability Carotolino to absorb radiation in region (400—500 nm). After 60-minute LED@450 nm exposure, corresponding maximum wavelength from displays common smartphones, only small changes (1.4 %) optical spectra were observed. showed sufficient photostability stabilizing effect photolabile Ubiquinone. In 415—455 range associated with oxidative stress, (0.4 % wt.) reduced by ∼97.0 %. EPR spin trapping that 450 causes significant formation reactive free radicals, which can be partially eliminated application Carotolino. results confirmed suitability both methods evaluate effectiveness substances reduce physical impact incident skin. Further needed investigate biological promising substances.
Language: Английский
Citations
1
Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 290, P. 117605 - 117605
Published: Dec. 31, 2024
The exposure of the general population to artificial light at night has dramatically increased in recent decades. Current standards for domestic lighting are based on acute and consider blue wavelengths be responsible phototoxicity. However, meta-analyses pointed out role lifelong onset age-related macular degeneration, suggesting a cumulative effect exposure. Here, we investigate retinal phototoxicity repeated emitting diodes different spectral compositions 6-week-old albino rats. Rats were exposed twice day 15 days doses that safe (0.1 0.2 J/cm² white lights, green 0.05 red light). We show rats repeatedly lights display irreversible damage, characterized by degradation global structure, significant photoreceptor loss, an increase stress inflammation markers. highlight protective addition mitigate light. All this points need rethink current taking into account parts emission spectrum.
Language: Английский
Citations
1
Current Eye Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 9
Published: Dec. 11, 2024
Age-related macular degeneration (AMD) is a chronic retinal disease that can lead to blindness. While the NLR family pyrin domain containing 3 (NLRP3) inflammasome implicated in AMD, specific roles of miR-21 and NLRP3 AMD-related inflammation remain unclear. Therefore, this study aimed investigate blue light-induced neurodegeneration mouse retina.
Language: Английский
Citations
0